Nuclear RNR-α antagonizes cell proliferation by directly inhibiting ZRANB3

Since the origins of DNA-based life, the enzyme ribonucleotide reductase (RNR) has spurred proliferation because of its rate-limiting role in de novo deoxynucleoside-triphosphate (dNTP) biosynthesis. Paradoxically, the large subunit, RNR-α, of this obligatory two-component complex in mammals plays a...

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Bibliographic Details
Published in:	Nature chemical biology Vol. 14; no. 10; pp. 943 - 954
Main Authors:	Fu, Yuan, Long, Marcus J. C., Wisitpitthaya, Somsinee, Inayat, Huma, Pierpont, Timothy M., Elsaid, Islam M., Bloom, Jordana C., Ortega, Joaquin, Weiss, Robert S., Aye, Yimon
Format:	Journal Article
Language:	English
Published:	New York Nature Publishing Group US 01-10-2018 Nature Publishing Group
Subjects:	631/337/1644 631/67 631/80/86 631/92/613 Active Transport, Cell Nucleus Animals Biochemical Engineering Biochemistry Biological activity Bioorganic Chemistry Biosynthesis Cell Biology Cell Cycle Cell Nucleus - metabolism Cell Proliferation Cercopithecus aethiops Chemistry Chemistry and Materials Science Chemistry/Food Science COS Cells Cytosol - metabolism Deoxyribonucleic acid DNA DNA - analysis DNA biosynthesis DNA Damage DNA Helicases - antagonists & inhibitors DNA Replication Fibroblasts - metabolism Growth rate HEK293 Cells HeLa Cells Humans K562 Cells Mice Mutagenesis Mutation NIH 3T3 Cells Nuclear transport Nucleotides Protein Binding Reductase Reductases Ribonucleotide reductase Ribonucleotide Reductases - metabolism RNA, Small Interfering - metabolism Signal Transduction
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