Cardiac interstitial tetraploid cells can escape replicative senescence in rodents but not large mammals

Cardiomyocyte ploidy has been described but remains obscure in cardiac interstitial cells. Ploidy of c-kit+ cardiac interstitial cells was assessed using confocal, karyotypic, and flow cytometric technique. Notable differences were found between rodent (rat, mouse) c-kit+ cardiac interstitial cells...

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Bibliographic Details
Published in:	Communications biology Vol. 2; no. 1; p. 205
Main Authors:	Broughton, Kathleen M., Khieu, Tiffany, Nguyen, Nicky, Rosa, Michael, Mohsin, Sadia, Quijada, Pearl, Wang, Bingyan J., Echeagaray, Oscar H., Kubli, Dieter A., Kim, Taeyong, Firouzi, Fareheh, Monsanto, Megan M., Gude, Natalie A., Adamson, Robert M., Dembitsky, Walter P., Davis, Michael E., Sussman, Mark A.
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 13-06-2019 Nature Publishing Group
Subjects:	13 13/100 13/31 13/51 14 14/19 631/532/2118/2440 631/532/2440 Animals Biology Biomedical and Life Sciences c-Kit protein Cardiomyocytes Cell Proliferation Cellular Senescence Clinical trials Colon Diploids Divergence Down-Regulation Female Flow Cytometry Gene Expression Profiling Heart Humans Interstitial cells Karyotyping Leukocytes, Mononuclear - cytology Life Sciences Male Mice Microscopy, Confocal Myocytes, Cardiac - metabolism p53 Protein Ploidies Ploidy Rats Senescence Signal Transduction Stem Cells - cytology Swine Tetraploidy Transcription Heart stem cells
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