Effects of Specific Sodium/Hydrogen Exchange Inhibitor During Cardioplegic Arrest

Background. The accumulation of intracellular sodium during myocardial ischemia couples an inappropriate calcium influx and depressed cardiac recovery during subsequent reperfusion. The effects of the selective sodium/hydrogen exchange inhibitor HOE 694 are evaluated during myocardial ischemia and r...

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Bibliographic Details
Published in:	The Annals of thoracic surgery Vol. 64; no. 1; pp. 94 - 99
Main Authors:	Choy, Isaac O, Schepkin, Victor D, Budinger, Thomas F, Obayashi, Derek Y, Young, J.Nilas, DeCampli, William M
Format:	Journal Article
Language:	English
Published:	New York, NY Elsevier Inc 01-07-1997 Elsevier Science
Subjects:	Animals Biological and medical sciences Cardioplegic Solutions Cardiovascular system Disease Models, Animal Guanidines - pharmacology Heart Arrest, Induced Hemodynamics In Vitro Techniques intracellular sodium Magnetic Resonance Spectroscopy Male Medical sciences Miscellaneous Myocardial Contraction myocardial ischemia Myocardial Ischemia - physiopathology Myocardial Reperfusion Injury - prevention & control Pharmacology. Drug treatments Rats Rats, Sprague-Dawley reperfusion injury Sodium - metabolism Sodium-Hydrogen Exchangers - antagonists & inhibitors Sulfones - pharmacology Ventricular Function, Left intracellular sodium myocardial ischemia reperfusion injury Cardioplegic solution Rat Rodentia Induced cardiocirculatory arrest Isolated organ Prevention Vertebrata Chemotherapy Mammalia Treatment Sodium Animal Myocardium Complication Inhibitor Ion exchange Potassium Protection
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