Understanding posttraumatic stress disorder through fear conditioning, extinction and reconsolidation

• Published in: Neuroscience and biobehavioral reviews Vol. 71; pp. 48 - 57
• Main Authors: Careaga, Mariella Bodemeier Loayza, Girardi, Carlos Eduardo Neves, Suchecki, Deborah
• Format: Journal Article
• Language: English
• Published: United States Elsevier Ltd 01-12-2016
• Subjects: Extinction; Extinction, Psychological; Fear; Fear conditioning; Humans; Memory; Memory persistence; PTSD; Reconsolidation; Stress Disorders, Post-Traumatic; PTSD; Memory persistence; Reconsolidation; Extinction; Fear conditioning
• ISSN: 0149-7634; 1873-7528
• DOI: 10.1016/j.neubiorev.2016.08.023

•Fear conditioning plays a major role in PTSD.•The main areas involved in fear conditioning are also altered in PTSD.•Persistence of traumatic memory could be a failure of extinction learning.•Exacerbated fear may also be a consequence of enhanced trauma-related memories through reconsolidation.
Careaga MBL, Girardi CEN, Suchecki D. Understanding posttraumatic stress disorder through fear conditioning, extinction and reconsolidation. NEUROSCI BIOBEHAV REV −Posttraumatic stress disorder (PTSD) is a psychopathology characterized by exacerbation of fear response. A dysregulated fear response may be explained by dysfunctional learning and memory, a hypothesis that was proposed decades ago. A key component of PTSD is fear conditioning and the study of this phenomenon in laboratory has expanded the understanding of the underlying neurobiological changes in PTSD. Furthermore, traumatic memories are strongly present even years after the trauma and maintenance of this memory is usually related to behavioral and physiological maladaptive responses. Persistence of traumatic memory may be explained by a dysregulation of two memory processes: extinction and reconsolidation. The former may explain the over-expression of fear responses as an imbalance between traumatic and extinction memory. The latter, in turn, explains the maintenance of fear responses as a result of enhancing trauma-related memories. Thus, this review will discuss the importance of fear conditioning for the establishment of PTSD and how failure in extinction or abnormal reconsolidation may contribute to the maintenance of fear response overtime.