Resection of positive tissue on methionine‐PET is associated with improved survival in glioblastomas

• Published in: Brain and behavior Vol. 13; no. 12; pp. e3291 - n/a
• Main Authors: Ohmura, Kazufumi, Daimon, Takashi, Ikegame, Yuka, Yano, Hirohito, Yokoyama, Kazutoshi, Kumagai, Morio, Shinoda, Jun, Iwama, Toru
• Format: Journal Article
• Language: English
• Published: United States John Wiley & Sons, Inc 01-12-2023; John Wiley and Sons Inc; Wiley
• Subjects: 11C‐methionine; Brain cancer; extent of resection; glioblastoma; Magnetic resonance imaging; Medical prognosis; Original; Patients; positron emission tomography; Radiation therapy; Surgery; survival; Tomography; Tumors; glioblastoma; extent of resection; positron emission tomography; 11C-methionine; survival
• ISSN: 2162-3279; 2162-3279
• DOI: 10.1002/brb3.3291

Background and purpose
The volume of excised tumor in contrast‐enhanced areas evaluated via magnetic resonance imaging is known to have a strong influence on the survival of patients with glioblastoma (GBM). In this study, we investigated the effect of tumor resection on the survival of patients with GBM in the 11C‐methionine (MET) accumulation area using MET‐positron emission tomography (MET‐PET).
Methods
A total of 26 patients (median age, 69 years; 15 males) who had undergone tumor resection and MET‐PET before and after surgery, after being newly diagnosed with GBM, were included in the study. MET‐PET before and after tumor resection were compared. The association between the decrease in the maximum standardized uptake value (SUV) of the tumor divided by the normal cortical mean SUV (%; ΔT/N), the MET extent of resection (MET‐EOR) from the % reduction in the MET accumulation area (%), and residual MET accumulation area (in cm3; MET‐residual tumor volume [RTV]), as well as the survival time of patients with GBM, were evaluated via univariate analysis.
Results
ΔT/N were positively associated with survival (hazard ratio [HR], 0.98 [95% confidence interval (CI), 0.97–0.99], p = .02). MET‐RTV revealed a negative association with survival (HR, 1.02 [95% CI, 1.01–1.04], p = .04). Additionally, MET‐EOR showed a strong trend with survival (HR, 0.99 [95% CI, 0.97–1.01], p = .06).
Conclusions
Surgical resection of MET‐accumulated areas in GBM significantly prolongs the survival of patients with GBM. However, a prospective large‐scale multicenter study is needed to confirm our findings.
We aimed to investigate the effect of tumor resection in the 11C‐methionine (MET) accumulation area evaluated via MET‐positron emission tomography on the survival of patients with glioblastoma (GBM). Surgical resection of MET‐positive areas in GBMs significantly prolongs the survival of patients with GBM.