Microalgae ( Chlorella vulgaris ) attenuates aflatoxin-associated renal injury
Aflatoxins (AFT) are ubiquitous environmental pollutants that are extremely dangerous for both human beings as well as animals. A safe, effective, and considerate strategy is therefore credited with controlling AFT intoxication. Therefore, our study aimed to evaluate the mitigating properties of (Ch...
Saved in:
| Published in: | Frontiers in pharmacology Vol. 14; p. 1291965 |
|---|---|
| Main Authors: | , , , , , , , , , , , , , |
| Format: | Journal Article |
| Language: | English |
| Published: |
Switzerland
Frontiers Media S.A
27-12-2023
|
| Subjects: | |
| Online Access: | Get full text |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| Abstract | Aflatoxins (AFT) are ubiquitous environmental pollutants that are extremely dangerous for both human beings as well as animals. A safe, effective, and considerate strategy is therefore credited with controlling AFT intoxication. Therefore, our study aimed to evaluate the mitigating properties of
(ChV) against AFT-induced nephrotoxicity and altered egg quality.
Quails were randomized into Control group (receiving a normal diet); ChV group (1 g/kg diet); AFT group (receiving an AFT-containing diet); and the AFT-ChV group were given both treatments.
AFT provoked kidney injury, exhibited by increased renal biochemical parameters and reduced protein levels. Malondialdehyde (MDA) levels dramatically increased as a consequence of AFT exposure, and glutathione (GSH) levels, superoxide dismutase (SOD), and glutathione peroxidase (GPx) activities were also decreased. Substantial up-modulation of the mRNA expression of the inflammatory cytokines (TNF-α, IL-1β, and IL-6) was additionally reported. Furthermore, AFT residues were detected in the egg compromising its quality and nutritional value. Contrarily, ChV supplemented diet suppressed the AFT-prompted oxidative stress and inflammation, together with enhancing the nutritional value and quality of eggs and decreasing AFT residues. These beneficial impacts are proposed to be attributed to its antioxidant and nutritional ingredients. The molecular docking dynamics confirmed the inflammatory and apoptotic protein targets for ChV. Our findings recommend that adding ChV supplements to foods might guard against nephrotoxicity brought on by AFT exposure. |
|---|---|
| AbstractList | Introduction:
Aflatoxins (AFT) are ubiquitous environmental pollutants that are extremely dangerous for both human beings as well as animals. A safe, effective, and considerate strategy is therefore credited with controlling AFT intoxication. Therefore, our study aimed to evaluate the mitigating properties of
Chlorella vulgaris
(ChV) against AFT-induced nephrotoxicity and altered egg quality.
Methods:
Quails were randomized into Control group (receiving a normal diet); ChV group (1 g/kg diet); AFT group (receiving an AFT-containing diet); and the AFT-ChV group were given both treatments.
Results and discussion:
AFT provoked kidney injury, exhibited by increased renal biochemical parameters and reduced protein levels. Malondialdehyde (MDA) levels dramatically increased as a consequence of AFT exposure, and glutathione (GSH) levels, superoxide dismutase (SOD), and glutathione peroxidase (GPx) activities were also decreased. Substantial up-modulation of the mRNA expression of the inflammatory cytokines (TNF-α, IL-1β, and IL-6) was additionally reported. Furthermore, AFT residues were detected in the egg compromising its quality and nutritional value. Contrarily, ChV supplemented diet suppressed the AFT-prompted oxidative stress and inflammation, together with enhancing the nutritional value and quality of eggs and decreasing AFT residues. These beneficial impacts are proposed to be attributed to its antioxidant and nutritional ingredients. The molecular docking dynamics confirmed the inflammatory and apoptotic protein targets for ChV. Our findings recommend that adding ChV supplements to foods might guard against nephrotoxicity brought on by AFT exposure. Introduction: Aflatoxins (AFT) are ubiquitous environmental pollutants that are extremely dangerous for both human beings as well as animals. A safe, effective, and considerate strategy is therefore credited with controlling AFT intoxication. Therefore, our study aimed to evaluate the mitigating properties of Chlorella vulgaris (ChV) against AFT-induced nephrotoxicity and altered egg quality. Methods: Quails were randomized into Control group (receiving a normal diet); ChV group (1 g/kg diet); AFT group (receiving an AFT-containing diet); and the AFT-ChV group were given both treatments. Results and discussion: AFT provoked kidney injury, exhibited by increased renal biochemical parameters and reduced protein levels. Malondialdehyde (MDA) levels dramatically increased as a consequence of AFT exposure, and glutathione (GSH) levels, superoxide dismutase (SOD), and glutathione peroxidase (GPx) activities were also decreased. Substantial up-modulation of the mRNA expression of the inflammatory cytokines (TNF-α, IL-1β, and IL-6) was additionally reported. Furthermore, AFT residues were detected in the egg compromising its quality and nutritional value. Contrarily, ChV supplemented diet suppressed the AFT-prompted oxidative stress and inflammation, together with enhancing the nutritional value and quality of eggs and decreasing AFT residues. These beneficial impacts are proposed to be attributed to its antioxidant and nutritional ingredients. The molecular docking dynamics confirmed the inflammatory and apoptotic protein targets for ChV. Our findings recommend that adding ChV supplements to foods might guard against nephrotoxicity brought on by AFT exposure. Introduction: Aflatoxins (AFT) are ubiquitous environmental pollutants that are extremely dangerous for both human beings as well as animals. A safe, effective, and considerate strategy is therefore credited with controlling AFT intoxication. Therefore, our study aimed to evaluate the mitigating properties of Chlorella vulgaris (ChV) against AFT-induced nephrotoxicity and altered egg quality.Methods: Quails were randomized into Control group (receiving a normal diet); ChV group (1 g/kg diet); AFT group (receiving an AFT-containing diet); and the AFT-ChV group were given both treatments.Results and discussion: AFT provoked kidney injury, exhibited by increased renal biochemical parameters and reduced protein levels. Malondialdehyde (MDA) levels dramatically increased as a consequence of AFT exposure, and glutathione (GSH) levels, superoxide dismutase (SOD), and glutathione peroxidase (GPx) activities were also decreased. Substantial up-modulation of the mRNA expression of the inflammatory cytokines (TNF-α, IL-1β, and IL-6) was additionally reported. Furthermore, AFT residues were detected in the egg compromising its quality and nutritional value. Contrarily, ChV supplemented diet suppressed the AFT-prompted oxidative stress and inflammation, together with enhancing the nutritional value and quality of eggs and decreasing AFT residues. These beneficial impacts are proposed to be attributed to its antioxidant and nutritional ingredients. The molecular docking dynamics confirmed the inflammatory and apoptotic protein targets for ChV. Our findings recommend that adding ChV supplements to foods might guard against nephrotoxicity brought on by AFT exposure. Aflatoxins (AFT) are ubiquitous environmental pollutants that are extremely dangerous for both human beings as well as animals. A safe, effective, and considerate strategy is therefore credited with controlling AFT intoxication. Therefore, our study aimed to evaluate the mitigating properties of (ChV) against AFT-induced nephrotoxicity and altered egg quality. Quails were randomized into Control group (receiving a normal diet); ChV group (1 g/kg diet); AFT group (receiving an AFT-containing diet); and the AFT-ChV group were given both treatments. AFT provoked kidney injury, exhibited by increased renal biochemical parameters and reduced protein levels. Malondialdehyde (MDA) levels dramatically increased as a consequence of AFT exposure, and glutathione (GSH) levels, superoxide dismutase (SOD), and glutathione peroxidase (GPx) activities were also decreased. Substantial up-modulation of the mRNA expression of the inflammatory cytokines (TNF-α, IL-1β, and IL-6) was additionally reported. Furthermore, AFT residues were detected in the egg compromising its quality and nutritional value. Contrarily, ChV supplemented diet suppressed the AFT-prompted oxidative stress and inflammation, together with enhancing the nutritional value and quality of eggs and decreasing AFT residues. These beneficial impacts are proposed to be attributed to its antioxidant and nutritional ingredients. The molecular docking dynamics confirmed the inflammatory and apoptotic protein targets for ChV. Our findings recommend that adding ChV supplements to foods might guard against nephrotoxicity brought on by AFT exposure. |
| Author | Fericean, Liana Abdelkader, Afaf Mihaela, Ostan Abdelfattah, Abdelfattah M Elbarbary, Nady Ibrahim, Samah F El-Hewaity, Mohamed Abdeen, Ahmed El-Far, Ali H Ibrahim, Samar S Elsabagh, Rasha Kadah, Amgad Y Said, Alshaimaa M Elbasuni, Sawsan S |
| AuthorAffiliation | 8 Department of Biology and Plant Protection , Faculty of Agriculture. University of Life Sciences “King Michael I" from Timișoara , Timișoara , Romania 11 Department of Food Hygiene , Faculty of Veterinary Medicine , Aswan University , Aswan , Egypt 6 Department of Biochemistry , Faculty of Veterinary Medicine , Damanhour University , Damanhour , Egypt 9 Department of Clinical Pathology , Faculty of Veterinary Medicine , University of Sadat City , Sadat City , Egypt 12 Department of Physiology , Faculty of Veterinary Medicine , Benha University , Toukh , Egypt 7 Department of Clinical Sciences , College of Medicine , Princess Nourah bint Abdulrahman University , Riyadh , Saudi Arabia 2 Department of Food Hygiene and Control , Faculty of Veterinary Medicine , Benha University , Toukh , Egypt 1 Department of Forensic Medicine and Toxicology , Faculty of Veterinary Medicine , Benha University , Toukh , Egypt 3 Department of Avian and Rabbit Diseases , Faculty of Veterinary Medicine , Benha Unive |
| AuthorAffiliation_xml | – name: 6 Department of Biochemistry , Faculty of Veterinary Medicine , Damanhour University , Damanhour , Egypt – name: 7 Department of Clinical Sciences , College of Medicine , Princess Nourah bint Abdulrahman University , Riyadh , Saudi Arabia – name: 5 Department of Forensic Medicine and Clinical Toxicology , Faculty of Medicine , Benha University , Benha , Egypt – name: 4 Department of Biochemistry , Faculty of Veterinary Medicine , Benha University , Toukh , Egypt – name: 10 Department of Pharmacology , Faculty of Veterinary Medicine , Menoufia University , Shebin Elkoum , Egypt – name: 1 Department of Forensic Medicine and Toxicology , Faculty of Veterinary Medicine , Benha University , Toukh , Egypt – name: 8 Department of Biology and Plant Protection , Faculty of Agriculture. University of Life Sciences “King Michael I" from Timișoara , Timișoara , Romania – name: 9 Department of Clinical Pathology , Faculty of Veterinary Medicine , University of Sadat City , Sadat City , Egypt – name: 13 Department of Zoology , College of Science , King Saud University , Riyadh , Saudi Arabia – name: 3 Department of Avian and Rabbit Diseases , Faculty of Veterinary Medicine , Benha University , Toukh , Egypt – name: 11 Department of Food Hygiene , Faculty of Veterinary Medicine , Aswan University , Aswan , Egypt – name: 12 Department of Physiology , Faculty of Veterinary Medicine , Benha University , Toukh , Egypt – name: 2 Department of Food Hygiene and Control , Faculty of Veterinary Medicine , Benha University , Toukh , Egypt |
| Author_xml | – sequence: 1 givenname: Ahmed surname: Abdeen fullname: Abdeen, Ahmed organization: Department of Forensic Medicine and Toxicology, Faculty of Veterinary Medicine, Benha University, Toukh, Egypt – sequence: 2 givenname: Rasha surname: Elsabagh fullname: Elsabagh, Rasha organization: Department of Food Hygiene and Control, Faculty of Veterinary Medicine, Benha University, Toukh, Egypt – sequence: 3 givenname: Sawsan S surname: Elbasuni fullname: Elbasuni, Sawsan S organization: Department of Avian and Rabbit Diseases, Faculty of Veterinary Medicine, Benha University, Toukh, Egypt – sequence: 4 givenname: Alshaimaa M surname: Said fullname: Said, Alshaimaa M organization: Department of Biochemistry, Faculty of Veterinary Medicine, Benha University, Toukh, Egypt – sequence: 5 givenname: Afaf surname: Abdelkader fullname: Abdelkader, Afaf organization: Department of Forensic Medicine and Clinical Toxicology, Faculty of Medicine, Benha University, Benha, Egypt – sequence: 6 givenname: Ali H surname: El-Far fullname: El-Far, Ali H organization: Department of Biochemistry, Faculty of Veterinary Medicine, Damanhour University, Damanhour, Egypt – sequence: 7 givenname: Samah F surname: Ibrahim fullname: Ibrahim, Samah F organization: Department of Clinical Sciences, College of Medicine, Princess Nourah bint Abdulrahman University, Riyadh, Saudi Arabia – sequence: 8 givenname: Ostan surname: Mihaela fullname: Mihaela, Ostan organization: Department of Biology and Plant Protection, Faculty of Agriculture. University of Life Sciences "King Michael I" from Timișoara, Timișoara, Romania – sequence: 9 givenname: Liana surname: Fericean fullname: Fericean, Liana organization: Department of Biology and Plant Protection, Faculty of Agriculture. University of Life Sciences "King Michael I" from Timișoara, Timișoara, Romania – sequence: 10 givenname: Abdelfattah M surname: Abdelfattah fullname: Abdelfattah, Abdelfattah M organization: Department of Clinical Pathology, Faculty of Veterinary Medicine, University of Sadat City, Sadat City, Egypt – sequence: 11 givenname: Mohamed surname: El-Hewaity fullname: El-Hewaity, Mohamed organization: Department of Pharmacology, Faculty of Veterinary Medicine, Menoufia University, Shebin Elkoum, Egypt – sequence: 12 givenname: Nady surname: Elbarbary fullname: Elbarbary, Nady organization: Department of Food Hygiene, Faculty of Veterinary Medicine, Aswan University, Aswan, Egypt – sequence: 13 givenname: Amgad Y surname: Kadah fullname: Kadah, Amgad Y organization: Department of Forensic Medicine and Toxicology, Faculty of Veterinary Medicine, Benha University, Toukh, Egypt – sequence: 14 givenname: Samar S surname: Ibrahim fullname: Ibrahim, Samar S organization: Department of Forensic Medicine and Toxicology, Faculty of Veterinary Medicine, Benha University, Toukh, Egypt |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/38205372$$D View this record in MEDLINE/PubMed |
| BookMark | eNpVkU1vGyEQhlGVKkmT_IEeqj0mh3X52gVOVWX1I1LaXtozmmXBxsLgwm7U_Pvg2I0SJMToZead0Tzv0ElM0SL0nuAFY1J9dLs15AXFlC0IVUT13Rt0TvqetUoSevIiPkNXpWxwPUwp1vNTdMYkxR0T9Bz9_OFNThBWYJvrZrkOKdsQoLmfq5R9aW4amCYbZ5hsacAFmNI_H1soJRlfxbHJNkJofNzM-eESvXUQir06vhfoz9cvv5ff27tf326Xn-9aw3s1tdbZQRrXU27pyInivJNSUeoMBlAcM2GJoZIKooZhZEJQ0zMpR4CucyA5u0C3B98xwUbvst9CftAJvH4SUl5pyJM3wWreGcXwUPsyyzF3SmIzQI9HXCdwQlSvTwev3Txs7WhsnDKEV6avf6Jf61W61wQLIbhk1eH66JDT39mWSW99Mfs9Rpvmoisfxrt6cU2lh9S69VKydc99CNZ7sPoJrN6D1UewtejDywmfS_5jZI-lNKHm |
| CitedBy_id | crossref_primary_10_3390_ph17070885 |
| Cites_doi | 10.1002/jcp.26479 10.3390/ani9100788 10.22207/JPAM.16.4.49 10.1186/s12906-018-2218-5 10.1007/s10811-010-9534-6 10.5713/ajas.2011.11273 10.1002/tox.23306 10.1080/0265203031000119025 10.4081/jphr.2021.2372 10.1016/j.fsi.2019.12.009 10.1126/science.abj8754 10.3389/fphar.2022.954030 10.1080/19440049.2012.720035 10.4162/nrp.2009.3.1.15 10.1016/j.heliyon.2019.e02470 10.1016/j.cofs.2017.11.009 10.1016/j.rvsc.2018.07.007 10.1016/j.biopha.2019.109608 10.1016/j.toxicon.2020.06.001 10.3389/fbioe.2023.1146881 10.1556/AVET.53.2005.3.5 10.3390/toxins11030176 10.1111/jfbc.13316 10.3389/fmars.2022.920082 10.1016/j.anifeedsci.2018.11.005 10.1016/j.biopha.2020.110627 10.1093/toxsci/kfp035 10.1016/j.biopha.2021.112154 10.1016/j.scitotenv.2020.144781 10.1080/09712119.2018.1436550 10.1017/s0043933919000047 10.1002/jbt.22929 10.15406/mojfpt.2018.06.00144 10.3390/MD19020113 10.29328/journal.ivs.1001037 10.1007/s12649-018-0370-2 10.1016/j.biopha.2023.115133 10.30574/gscbps.2023.22.2.0067 10.1016/j.ecoenv.2022.113319 10.3390/ph15060736 10.3390/toxins14090605 10.3390/toxins14120843 10.1016/j.psj.2021.101513 10.3390/antiox11061082 10.3390/antiox11091787 |
| ContentType | Journal Article |
| Copyright | Copyright © 2023 Abdeen, Elsabagh, Elbasuni, Said, Abdelkader, El-Far, Ibrahim, Mihaela, Fericean, Abdelfattah, El-Hewaity, Elbarbary, Kadah and Ibrahim. Copyright © 2023 Abdeen, Elsabagh, Elbasuni, Said, Abdelkader, El-Far, Ibrahim, Mihaela, Fericean, Abdelfattah, El-Hewaity, Elbarbary, Kadah and Ibrahim. 2023 Abdeen, Elsabagh, Elbasuni, Said, Abdelkader, El-Far, Ibrahim, Mihaela, Fericean, Abdelfattah, El-Hewaity, Elbarbary, Kadah and Ibrahim |
| Copyright_xml | – notice: Copyright © 2023 Abdeen, Elsabagh, Elbasuni, Said, Abdelkader, El-Far, Ibrahim, Mihaela, Fericean, Abdelfattah, El-Hewaity, Elbarbary, Kadah and Ibrahim. – notice: Copyright © 2023 Abdeen, Elsabagh, Elbasuni, Said, Abdelkader, El-Far, Ibrahim, Mihaela, Fericean, Abdelfattah, El-Hewaity, Elbarbary, Kadah and Ibrahim. 2023 Abdeen, Elsabagh, Elbasuni, Said, Abdelkader, El-Far, Ibrahim, Mihaela, Fericean, Abdelfattah, El-Hewaity, Elbarbary, Kadah and Ibrahim |
| DBID | NPM AAYXX CITATION 7X8 5PM DOA |
| DOI | 10.3389/fphar.2023.1291965 |
| DatabaseName | PubMed CrossRef MEDLINE - Academic PubMed Central (Full Participant titles) DOAJ Directory of Open Access Journals |
| DatabaseTitle | PubMed CrossRef MEDLINE - Academic |
| DatabaseTitleList | CrossRef MEDLINE - Academic PubMed |
| Database_xml | – sequence: 1 dbid: DOA name: Directory of Open Access Journals url: http://www.doaj.org/ sourceTypes: Open Website |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Pharmacy, Therapeutics, & Pharmacology |
| DocumentTitleAlternate | Abdeen et al |
| EISSN | 1663-9812 |
| EndPage | 1291965 |
| ExternalDocumentID | oai_doaj_org_article_45c930b4693e404f980cba60d08cff77 10_3389_fphar_2023_1291965 38205372 |
| Genre | Journal Article |
| GroupedDBID | 53G 5VS 9T4 AAFWJ AAKDD ACGFO ACGFS ACXDI ADBBV ADRAZ AENEX AFPKN ALMA_UNASSIGNED_HOLDINGS AOIJS BAWUL BCNDV DIK EMOBN GROUPED_DOAJ GX1 HYE IAO IEA IHR IHW IPNFZ KQ8 M48 M~E NPM O5R O5S OK1 P2P PGMZT RIG RNS RPM AAYXX CITATION 7X8 5PM |
| ID | FETCH-LOGICAL-c469t-efeb8cf624e2d41944588922fc0aa94037e1c282719bbd3772c6388daa55fa843 |
| IEDL.DBID | RPM |
| ISSN | 1663-9812 |
| IngestDate | Tue Oct 22 15:16:14 EDT 2024 Tue Sep 17 21:29:00 EDT 2024 Sat Oct 26 01:08:16 EDT 2024 Thu Sep 26 16:05:27 EDT 2024 Sat Nov 02 12:09:30 EDT 2024 |
| IsDoiOpenAccess | true |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Keywords | apoptosis inflammatory cytokines computational modeling oxidative stress Japanese quail residues |
| Language | English |
| License | Copyright © 2023 Abdeen, Elsabagh, Elbasuni, Said, Abdelkader, El-Far, Ibrahim, Mihaela, Fericean, Abdelfattah, El-Hewaity, Elbarbary, Kadah and Ibrahim. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c469t-efeb8cf624e2d41944588922fc0aa94037e1c282719bbd3772c6388daa55fa843 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 Edited by: Patrícia Mendonça Rijo, Lusofona University, Portugal Reviewed by: Taghred M. Saber, Zagazig University, Egypt Mohamed L. Ashour, Ain Shams University, Egypt |
| OpenAccessLink | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10777483/ |
| PMID | 38205372 |
| PQID | 2913451340 |
| PQPubID | 23479 |
| PageCount | 1 |
| ParticipantIDs | doaj_primary_oai_doaj_org_article_45c930b4693e404f980cba60d08cff77 pubmedcentral_primary_oai_pubmedcentral_nih_gov_10777483 proquest_miscellaneous_2913451340 crossref_primary_10_3389_fphar_2023_1291965 pubmed_primary_38205372 |
| PublicationCentury | 2000 |
| PublicationDate | 2023-12-27 |
| PublicationDateYYYYMMDD | 2023-12-27 |
| PublicationDate_xml | – month: 12 year: 2023 text: 2023-12-27 day: 27 |
| PublicationDecade | 2020 |
| PublicationPlace | Switzerland |
| PublicationPlace_xml | – name: Switzerland |
| PublicationTitle | Frontiers in pharmacology |
| PublicationTitleAlternate | Front Pharmacol |
| PublicationYear | 2023 |
| Publisher | Frontiers Media S.A |
| Publisher_xml | – name: Frontiers Media S.A |
| References | Dlamini (B18) 2021; 36 Gao (B22) 2021; 100 Abdel-Daim (B4) 2021; 768 Elbasuni (B19) 2022; 14 Abdeen (B2) 2021; 143 Blas-Valdivia (B15) 2011; 23 Kolosova (B27) 2012; 29 Yilmaz (B43) 2018; 119 Manafi (B30) 2018; 46 Remize (B36) 2021; 19 Abdelhamid (B5) 2020; 96 Abdelnaby (B6) 2022; 13 Al-Halaseh (B12) 2022; 16 Lamminen (B28) 2019; 247 Owumi (B33) 2020; 44 Abdeen (B1) 2020; 130 Andrade (B13) 2018; 6 Kemal (B26) 2023; 22 Citil (B17) 2005; 53 Fouad (B21) 2019; 11 Elgazzar (B20) 2022; 15 Halle (B24) 2009; 12 Li (B29) 2022; 233 Abdel-Daim (B3) 2020; 184 Baek (B14) 2021; 373 Ahmed (B11) 2022; 14 Prabakaran (B34) 2019; 10 Zhu (B46) 2020; 121 Abdelnour (B7); 75 Oliveira (B32) 2003; 20 Rajendran (B35) 2018; 233 Hebels (B25) 2009; 108 Sikiru (B38) 2019; 5 Yilmaz (B42) 2022; 2022 Medina (B31) 2017; 18 Habotta (B23) 2023; 165 Abdelnour (B8); 9 Shim (B37) 2009; 3 Wispriyono (B40) 2021; 10 Zhang (B44) 2022; 11 Aboubakr (B9) 2021; 35 Yang (B41) 2022; 9 Chen (B16) 2023; 11 Abu-Serie (B10) 2018; 18 Wang (B39) 2022; 11 Zheng (B45) 2012; 25 |
| References_xml | – volume: 233 start-page: 6458 year: 2018 ident: B35 article-title: The multifaceted link between inflammation and human diseases publication-title: J. Cell. Physiol. doi: 10.1002/jcp.26479 contributor: fullname: Rajendran – volume: 9 start-page: 788 ident: B8 article-title: Impacts of enriching growing rabbit diets with chlorella vulgaris microalgae on growth, blood variables, carcass traits, immunological and antioxidant indices publication-title: Animals doi: 10.3390/ani9100788 contributor: fullname: Abdelnour – volume: 16 start-page: 2775 year: 2022 ident: B12 article-title: Nephroprotective activity of green microalgae, chlorella sorokiniana isolated from Jordanian water publication-title: J. Pure Appl. Microbiol. doi: 10.22207/JPAM.16.4.49 contributor: fullname: Al-Halaseh – volume: 18 start-page: 154 year: 2018 ident: B10 article-title: In vitro evaluation of the synergistic antioxidant and anti-inflammatory activities of the combined extracts from Malaysian Ganoderma lucidum and Egyptian Chlorella vulgaris publication-title: BMC Complement. Altern. Med. doi: 10.1186/s12906-018-2218-5 contributor: fullname: Abu-Serie – volume: 23 start-page: 53 year: 2011 ident: B15 article-title: Chlorella vulgaris administration prevents HgCl2-caused oxidative stress and cellular damage in the kidney publication-title: J. Appl. Phycol. doi: 10.1007/s10811-010-9534-6 contributor: fullname: Blas-Valdivia – volume: 25 start-page: 261 year: 2012 ident: B45 article-title: The dietary effects of fermented chlorella vulgaris (CBT(®)) on production performance, liver lipids and intestinal microflora in laying hens publication-title: Asian-Australasian J. Anim. Sci. doi: 10.5713/ajas.2011.11273 contributor: fullname: Zheng – volume: 36 start-page: 1857 year: 2021 ident: B18 article-title: Toxicogenicity and mechanistic pathways of aflatoxin B1 induced renal injury publication-title: Environ. Toxicol. doi: 10.1002/tox.23306 contributor: fullname: Dlamini – volume: 12 start-page: 5 year: 2009 ident: B24 article-title: Effect of microalgae Chlorella vulgaris on laying hen performance publication-title: Arch. Zootech. contributor: fullname: Halle – volume: 20 start-page: 648 year: 2003 ident: B32 article-title: Aflatoxin residues in eggs of laying Japanese quail after long-term administration of rations containing low levels of aflatoxin B1 publication-title: Food Addit. Contam. doi: 10.1080/0265203031000119025 contributor: fullname: Oliveira – volume: 10 start-page: 2372 year: 2021 ident: B40 article-title: Glutathione (GSH) and superoxide dismutase (SOD) levels among junior high school students induced by indoor particulate matter 2.5 (PM2.5) and nitrogen dioxide (NO2) exposure publication-title: J. Public Health Res. doi: 10.4081/jphr.2021.2372 contributor: fullname: Wispriyono – volume: 96 start-page: 213 year: 2020 ident: B5 article-title: Ameliorative effects of dietary Chlorella vulgaris and β-glucan against diazinon-induced toxicity in Nile tilapia (Oreochromis niloticus) publication-title: Fish. Shellfish Immunol. doi: 10.1016/j.fsi.2019.12.009 contributor: fullname: Abdelhamid – volume: 373 start-page: 871 year: 2021 ident: B14 article-title: Accurate prediction of protein structures and interactions using a three-track neural network publication-title: Yearb. Paediatr. Endocrinol. doi: 10.1126/science.abj8754 contributor: fullname: Baek – volume: 13 start-page: 954030 year: 2022 ident: B6 article-title: The combination of Tamarindus indica and coenzyme Q10 can be a potential therapy preference to attenuate cadmium-induced hepatorenal injury publication-title: Front. Pharmacol. doi: 10.3389/fphar.2022.954030 contributor: fullname: Abdelnaby – volume: 29 start-page: 1959 year: 2012 ident: B27 article-title: Evaluation of the effect of mycotoxin binders in animal feed on the analytical performance of standardised methods for the determination of mycotoxins in feed publication-title: Food Addit. Contam. Part A doi: 10.1080/19440049.2012.720035 contributor: fullname: Kolosova – volume: 3 start-page: 15 year: 2009 ident: B37 article-title: Effect of Chlorella intake on Cadmium metabolism in rats publication-title: Nutr. Res. Pract. doi: 10.4162/nrp.2009.3.1.15 contributor: fullname: Shim – volume: 5 start-page: e02470 year: 2019 ident: B38 article-title: Chlorella vulgaris supplementation effects on performances, oxidative stress and antioxidant genes expression in liver and ovaries of New Zealand White rabbits publication-title: Heliyon doi: 10.1016/j.heliyon.2019.e02470 contributor: fullname: Sikiru – volume: 18 start-page: 76 year: 2017 ident: B31 article-title: Impact of global warming on mycotoxins publication-title: Curr. Opin. Food Sci. doi: 10.1016/j.cofs.2017.11.009 contributor: fullname: Medina – volume: 119 start-page: 268 year: 2018 ident: B43 article-title: Aflatoxin B1 induced renal and cardiac damage in rats: protective effect of lycopene publication-title: Res. Vet. Sci. doi: 10.1016/j.rvsc.2018.07.007 contributor: fullname: Yilmaz – volume: 121 start-page: 109608 year: 2020 ident: B46 article-title: A new compound Trichomicin exerts antitumor activity through STAT3 signaling inhibition publication-title: Biomed. Pharmacother. doi: 10.1016/j.biopha.2019.109608 contributor: fullname: Zhu – volume: 184 start-page: 152 year: 2020 ident: B3 article-title: Spirulina platensis mediated the biochemical indices and antioxidative function of Nile tilapia (Oreochromis niloticus) intoxicated with aflatoxin B1 publication-title: Toxicon doi: 10.1016/j.toxicon.2020.06.001 contributor: fullname: Abdel-Daim – volume: 11 start-page: 1146881 year: 2023 ident: B16 article-title: Microalgal polyunsaturated fatty acids: hotspots and production techniques publication-title: Front. Bioeng. Biotechnol. doi: 10.3389/fbioe.2023.1146881 contributor: fullname: Chen – volume: 53 start-page: 319 year: 2005 ident: B17 article-title: Protective effect of L-carnitine against oxidative damage caused by experimental chronic aflatoxicosis in quail (Coturnix coturnix) publication-title: Acta Vet. Hung. doi: 10.1556/AVET.53.2005.3.5 contributor: fullname: Citil – volume: 11 start-page: 1 year: 2019 ident: B21 article-title: Harmful effects and control strategies of aflatoxin B₁ produced by Aspergillus flavus and Aspergillus parasiticus strains on poultry: review publication-title: Toxins (Basel). doi: 10.3390/toxins11030176 contributor: fullname: Fouad – volume: 44 start-page: e13316 year: 2020 ident: B33 article-title: Gallic acid protects against Aflatoxin B1 -induced oxidative and inflammatory stress damage in rats kidneys and liver publication-title: J. Food Biochem. doi: 10.1111/jfbc.13316 contributor: fullname: Owumi – volume: 9 start-page: 1 year: 2022 ident: B41 article-title: Anti-inflammatory effect of acetone extracts from microalgae chlorella sp. WZ13 on RAW264.7 cells and TPA-induced ear edema in mice publication-title: Front. Mar. Sci. doi: 10.3389/fmars.2022.920082 contributor: fullname: Yang – volume: 247 start-page: 112 year: 2019 ident: B28 article-title: Different microalgae species as a substitutive protein feed for soya bean meal in grass silage based dairy cow diets publication-title: Anim. Feed Sci. Technol. doi: 10.1016/j.anifeedsci.2018.11.005 contributor: fullname: Lamminen – volume: 130 start-page: 110627 year: 2020 ident: B1 article-title: Coenzyme Q10 supplementation mitigates piroxicam-induced oxidative injury and apoptotic pathways in the stomach, liver, and kidney publication-title: Biomed. Pharmacother. doi: 10.1016/j.biopha.2020.110627 contributor: fullname: Abdeen – volume: 108 start-page: 290 year: 2009 ident: B25 article-title: Molecular signatures of N-nitroso compounds in Caco-2 cells: implications for colon carcinogenesis publication-title: Toxicol. Sci. doi: 10.1093/toxsci/kfp035 contributor: fullname: Hebels – volume: 143 start-page: 112154 year: 2021 ident: B2 article-title: The potential antioxidant bioactivity of date palm fruit against gentamicin-mediated hepato-renal injury in male albino rats publication-title: Biomed. Pharmacother. doi: 10.1016/j.biopha.2021.112154 contributor: fullname: Abdeen – volume: 768 start-page: 144781 year: 2021 ident: B4 article-title: Fucoidan supplementation modulates hepato-renal oxidative stress and DNA damage induced by aflatoxin B1 intoxication in rats publication-title: Sci. Total Environ. doi: 10.1016/j.scitotenv.2020.144781 contributor: fullname: Abdel-Daim – volume: 46 start-page: 953 year: 2018 ident: B30 article-title: Toxicity of aflatoxin B1 on laying Japanese quails (Coturnix coturnix japonica) publication-title: J. Appl. Anim. Res. doi: 10.1080/09712119.2018.1436550 contributor: fullname: Manafi – volume: 75 start-page: 305 ident: B7 article-title: The application of the microalgae Chlorella spp. as a supplement in broiler feed publication-title: Worlds. Poult. Sci. J. doi: 10.1017/s0043933919000047 contributor: fullname: Abdelnour – volume: 35 start-page: e22929 year: 2021 ident: B9 article-title: Cefepime and diclofenac sodium combined treatment-potentiated multiple organ injury: role of oxidative damage and disrupted lipid metabolism publication-title: J. Biochem. Mol. Toxicol. doi: 10.1002/jbt.22929 contributor: fullname: Aboubakr – volume: 6 start-page: 45 year: 2018 ident: B13 article-title: Chlorella and spirulina microalgae as sources of functional foods, nutraceuticals, and food supplements; an overview publication-title: Nutraceuticals, Food Suppl. doi: 10.15406/mojfpt.2018.06.00144 contributor: fullname: Andrade – volume: 19 start-page: 113 year: 2021 ident: B36 article-title: Microalgae n-3 PUFAs production and use in food and feed industries publication-title: Mar. Drugs doi: 10.3390/MD19020113 contributor: fullname: Remize – volume: 2022 start-page: 17 year: 2022 ident: B42 article-title: Afl atoxin B1: mechanism, oxidative stress, and eff ects on animal health publication-title: J. Animal Biol. Veterinary Med. doi: 10.29328/journal.ivs.1001037 contributor: fullname: Yilmaz – volume: 10 start-page: 3263 year: 2019 ident: B34 article-title: Evaluation of chemical composition and in vitro antiinflammatory effect of marine microalgae chlorella vulgaris publication-title: Waste Biomass Valorization doi: 10.1007/s12649-018-0370-2 contributor: fullname: Prabakaran – volume: 165 start-page: 115133 year: 2023 ident: B23 article-title: Sesquiterpene nootkatone counteracted the melamine-induced neurotoxicity via repressing of oxidative stress, inflammatory, and apoptotic trajectories publication-title: Biomed. Pharmacother. doi: 10.1016/j.biopha.2023.115133 contributor: fullname: Habotta – volume: 22 start-page: 196 year: 2023 ident: B26 article-title: Determination of glutathione peroxidase activity and oxidized/reduced glutathione ratio in patients with colon cancer publication-title: GSC Biol. Pharm. Sci. doi: 10.30574/gscbps.2023.22.2.0067 contributor: fullname: Kemal – volume: 233 start-page: 113319 year: 2022 ident: B29 article-title: Protective role of curcumin on aflatoxin B1-induced TLR4/RIPK pathway mediated-necroptosis and inflammation in chicken liver publication-title: Ecotoxicol. Environ. Saf. doi: 10.1016/j.ecoenv.2022.113319 contributor: fullname: Li – volume: 15 year: 2022 ident: B20 article-title: Tigecycline and gentamicin-combined treatment enhances renal damage: oxidative stress, inflammatory reaction, and apoptosis interplay publication-title: Pharmaceuticals doi: 10.3390/ph15060736 contributor: fullname: Elgazzar – volume: 14 start-page: 605 year: 2022 ident: B11 article-title: Arabic gum could alleviate the aflatoxin B1-provoked hepatic injury in rat: the involvement of oxidative stress, inflammatory, and apoptotic pathways publication-title: Toxins (Basel) doi: 10.3390/toxins14090605 contributor: fullname: Ahmed – volume: 14 start-page: 843 year: 2022 ident: B19 article-title: The preferential therapeutic potential of chlorella vulgaris against aflatoxin-induced hepatic injury in quail publication-title: Toxins (Basel). doi: 10.3390/toxins14120843 contributor: fullname: Elbasuni – volume: 100 start-page: 101513 year: 2021 ident: B22 article-title: Morin alleviates aflatoxin B1-induced liver and kidney injury by inhibiting heterophil extracellular traps release, oxidative stress and inflammatory responses in chicks publication-title: Poult. Sci. doi: 10.1016/j.psj.2021.101513 contributor: fullname: Gao – volume: 11 start-page: 1082 year: 2022 ident: B39 article-title: Alleviation of oral exposure to aflatoxin B1-induced renal dysfunction, oxidative stress, and cell apoptosis in mice kidney by curcumin publication-title: Antioxidants doi: 10.3390/antiox11061082 contributor: fullname: Wang – volume: 11 start-page: 1787 year: 2022 ident: B44 article-title: Genome-scale CRISPR knockout screening identifies BACH1 as a key regulator of aflatoxin B1-induced oxidative damage publication-title: Antioxidants doi: 10.3390/antiox11091787 contributor: fullname: Zhang |
| SSID | ssj0000399364 |
| Score | 2.3976064 |
| Snippet | Aflatoxins (AFT) are ubiquitous environmental pollutants that are extremely dangerous for both human beings as well as animals. A safe, effective, and... Introduction: Aflatoxins (AFT) are ubiquitous environmental pollutants that are extremely dangerous for both human beings as well as animals. A safe,... Introduction: Aflatoxins (AFT) are ubiquitous environmental pollutants that are extremely dangerous for both human beings as well as animals. A safe,... |
| SourceID | doaj pubmedcentral proquest crossref pubmed |
| SourceType | Open Website Open Access Repository Aggregation Database Index Database |
| StartPage | 1291965 |
| SubjectTerms | apoptosis computational modeling inflammatory cytokines Japanese quail oxidative stress Pharmacology residues |
| SummonAdditionalLinks | – databaseName: DOAJ Directory of Open Access Journals dbid: DOA link: http://sdu.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV3NT9VAEJ8oJy9GxY8imiUxRCOV7X683R4FIRzAkIiJt812P_IeIYXwKJH_3pm2PHjGxAuHXtomO5lfd2d-3ZnfAnzIinvpkZaYVKVSRUFzLpiyyhOdmmgq3dD_joMf5vsv-22PZHIWR31RTdggDzw4blvpUEveIIuTSXGVa8tD4yc8chtyNkMfObf3yFS_BlPcnaihSwZZWL2dL6ae9D-F_IIhjnT0liJRL9j_ryzz72LJe9Fn_xk8HdNG9nUw9zk8Su0L2DwedKdvttjJXRvVfIttsuM7ReqbVTg8orI76tpI7OPuFCk61Tyx6476OGbzT4xENtuO0k7m8xny8N-ztvQjcimyy0Sjz9pTROAl_NzfO9k9KMdjFMqAXrsqU04N-moiVBJRVbWi5tRaiBy497XiEmEKyLxMVTdNlJhuB5yUNnqvdfZWyVew0p636Q2wWCGsWhltglRRalxKI1LcIA33VahtAZ9vXeouBrUMhyyDAHA9AI4AcCMABeyQ1xdvktJ1fwPxdyP-7n_4F7Bxi5nDmUHbHb5N593cCSoq0HjxAl4PGC6Gkpj4aGlEAXYJ3SVblp-0s2mvvo18GVNmK9cewvq38IQ8QvUxwqzDytVll97B43ns3vcf9B-HC_s1 priority: 102 providerName: Directory of Open Access Journals |
| Title | Microalgae ( Chlorella vulgaris ) attenuates aflatoxin-associated renal injury |
| URI | https://www.ncbi.nlm.nih.gov/pubmed/38205372 https://search.proquest.com/docview/2913451340 https://pubmed.ncbi.nlm.nih.gov/PMC10777483 https://doaj.org/article/45c930b4693e404f980cba60d08cff77 |
| Volume | 14 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://sdu.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Lb9QwELbYnrgg3oRHZSRUgWh2ndiOkyMsrXqgaCWKxM1y_GCD2uxqt0H03zPjJG0XceKQSx5yPJ_tmc-Z-ULImyCY4QZoifKZT4XLcc5ZlWahkL52KpM17necfFVfvpefjlAmpxhrYWLSvq2baXt-MW2bZcytXF_Y2ZgnNluczoGyQNRS8tmETCA4vMXR4_qLPrcQfYUMMLBqFtZLg9qfOZ-Ce0MNvR0vFMX6_xVh_p0oecvzHN8n94aQkX7oX-0BuePbh-Rg0WtOXx3Ss5sSqu0hPaCLGzXqq0fk8ymm3GHFhqdv50ug55jvRH91WMPRbN9RFNhsOww5qQnnwMF_N21qBtS8oxuPrTftT7D-Y_Lt-OhsfpIOv1BILfDey9QHX5c2FLnwuRNZJbAwtcrzYJkxlWAcILLAulRW1bXjEGpbmJClM0bKYErBn5C9dtX6Z4S6DCCVQklluXBcwjLqgN5arpjJbFUm5P1oUr3ulTI0MAwEQEcANAKgBwAS8hGtfn0nqlzHE6vNDz1grYW0FWc19IR7wUSoSmZrUzDHoE9BqYS8HjHTMCvwU4dp_arb6hwTCiQcLCFPewyvm-IQ9Eiu8oSUO-juvMvuFRiIUXl7HHjP___RF-Qu2gEzYnL1kuxdbjr_iky2rtuP-wH7cTD_Aa9H-5g |
| link.rule.ids | 230,315,729,782,786,866,887,2108,27935,27936,53803,53805 |
| linkProvider | National Library of Medicine |
| linkToHtml | http://sdu.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Jb9NAFB7RcoAL--KyDRKqQNTJ2DP22EcIrYJIqkgEidtoPAtx1TpRUiP673nPS9sgTj344kWzfPPmvc9-7zMh77xgmmugJdJFLhQ2RpszMox8mrjCyigp8H3H-Ls8_pl9OUSZnLSvhWmS9k1RDqrTs0FVLprcytWZGfZ5YsPZdASUBaKWjA93yG0wWMavsfRmB0avm4q2RgY4WD70q4VG9c-YD8DBoYrelh9q5Pr_F2P-myp5zfcc3b9prx-Qe120ST-11x-SW656RPZnrVz1xQGdX1VfbQ7oPp1dCVlfPCaTKWbrYbGHo-9HC2D2mCpFf9dY_lFuPlDU5qxqjFap9qdA3_-UVag7wJ2la4etl9UJAPeE_Dg6nI_GYff3hdAAZT4PnXdFZnwaCxdbEeUCa1rzOPaGaZ0LxgFdA4RNRnlRWA5RugFbzqzWSeJ1JvhTslstK_ecUBvBakiETKThwvIEdmALzNhwyXRk8iwgH3ss1KoV2VBAThA51SCnEDnVIReQzwjX5Z0okN2cWK5_qW7ClUhMzlkBI-FOMOHzjJlCp8wyGJOXMiBve7AVGBR-JdGVW9YbFWMuQgIHC8izFvzLpjjESwmXcUCyrWWx1ZftK7AaGtHuHv29mz_6htwZz6cTNfl6_O0FuYtzgok1sXxJds_XtXtFdja2ft3Ywl-wmhBz |
| linkToPdf | http://sdu.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV1Lb9QwELZokRAX3o8tLyOhCkSzcWJ7nXCDbVdFtNVKFImb5fjBpmqzq90G0X_PTB5tF3GCQy6JI8f-Zuz5kpkvhLwJghlugJYon_hIuBR9zqooCSPpC6cSWeD7jv2v6uh7truHMjkf-lqYJmnfFuWwOj0bVuWsya1cnNm4zxOLp4djoCwQtWQ8XrgQb5Cb4LRMXmPqzSqMO-9ItHUywMPyOCxmBhVAUz6ETQ6V9Nb2okay_29x5p_pktf2n8nd_3nye-ROF3XSj22b--SGrx6Q7WkrW32xQ4-vqrBWO3SbTq8ErS8ekoNDzNrDog9P345nwPAxZYr-rLEMpFy9o6jRWdUYtVITToHG_yqryHTAe0eXHnsvqxMA8BH5Ntk7Hu9H3V8YIgvU-TzywReZDaNU-NSJJBdY25qnabDMmFwwDihbIG4qyYvCcYjWLfh05oyRMphM8Mdks5pX_imhLgGrkEJJZblwXMJK7IAhW66YSWyeDcj7Hg-9aMU2NJAURE836GlET3foDcgnhOyyJQplNyfmyx-6m3QtpM05K2Ak3AsmQp4xW5gRcwzGFJQakNc94BocC7-WmMrP65VOMSdBwsEG5ElrAJddcYibJFfpgGRrprH2LOtXwCIa8e7eArb-_dZX5NZ0d6IPPh99eUZu45Rgfk2qnpPN82XtX5CNlatfNu7wGzenEvM |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Microalgae+%28Chlorella+vulgaris%29+attenuates+aflatoxin-associated+renal+injury&rft.jtitle=Frontiers+in+pharmacology&rft.au=Abdeen%2C+Ahmed&rft.au=Elsabagh%2C+Rasha&rft.au=Elbasuni%2C+Sawsan+S&rft.au=Said%2C+Alshaimaa+M&rft.date=2023-12-27&rft.issn=1663-9812&rft.eissn=1663-9812&rft.volume=14&rft.spage=1291965&rft.epage=1291965&rft_id=info:doi/10.3389%2Ffphar.2023.1291965&rft.externalDBID=NO_FULL_TEXT |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1663-9812&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1663-9812&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1663-9812&client=summon |