Public-Private Partnership: A New Engine for Translational Research in Neurosciences

We have made little recent progress developing effective new treatments for neuropsychiatric and neurodevelopmental disorders. Novel molecular mechanisms have been identified, but have not translated into the clinic. We suggest an alternative: combinations of treatments targeting different aspects o...

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Published in:	Neuron (Cambridge, Mass.) Vol. 84; no. 3; pp. 533 - 536
Main Authors:	Murphy, Declan G.M., Goldman, Michel, Loth, Eva, Spooren, Will
Format:	Journal Article
Language:	English
Published:	United States Elsevier Inc 05-11-2014 Elsevier Limited
Subjects:	Autism Behavior Biomarkers Brain research Cancer Cancer therapies Humans Medical research Mental Disorders - diagnosis Mental Disorders - therapy Nervous System Diseases - diagnosis Nervous System Diseases - therapy Neurosciences Neurosciences - methods Neurosciences - trends Pharmaceutical industry Public-Private Sector Partnerships Regulatory approval Rodents Studies Translational Medical Research - methods Translational Medical Research - trends United States > US
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Abstract	We have made little recent progress developing effective new treatments for neuropsychiatric and neurodevelopmental disorders. Novel molecular mechanisms have been identified, but have not translated into the clinic. We suggest an alternative: combinations of treatments targeting different aspects of final common pathways in biologically defined clinical subgroups. This will require integrated translational neuroscience and international public-private partnerships.
AbstractList	We have made little recent progress developing effective new treatments for neuropsychiatric and neurodevelopmental disorders. Novel molecular mechanisms have been identified, but have not translated into the clinic. We suggest an alternative: combinations of treatments targeting different aspects of final common pathways in biologically defined clinical subgroups. This will require integrated translational neuroscience and international public-private partnerships.
Author	Goldman, Michel Loth, Eva Murphy, Declan G.M. Spooren, Will
Author_xml	– sequence: 1 givenname: Declan G.M. surname: Murphy fullname: Murphy, Declan G.M. email: declan.murphy@kcl.ac.uk organization: The Sackler Institute for Translational Neurodevelopment, Institute of Psychiatry, King’s College London, London SE5 8AF, UK – sequence: 2 givenname: Michel surname: Goldman fullname: Goldman, Michel organization: Innovative Medicines Initiative, Brussels 1060, Belgium – sequence: 3 givenname: Eva surname: Loth fullname: Loth, Eva organization: The Sackler Institute for Translational Neurodevelopment, Institute of Psychiatry, King’s College London, London SE5 8AF, UK – sequence: 4 givenname: Will surname: Spooren fullname: Spooren, Will organization: Behavioural Pharmacology and Preclinical Imaging, Roche Pharmaceuticals, Basel 4070, Switzerland
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Cites_doi	10.1001/archgenpsychiatry.2012.513 10.1523/JNEUROSCI.5413-09.2010 10.1038/nm0612-840 10.1038/nrd4395 10.1038/nrd3881 10.1038/tp.2013.53 10.1038/nature11396 10.1093/brain/awt216 10.1093/brain/awu178 10.4088/JCP.13m08853 10.1038/nature10110 10.1126/science.1224159 10.1016/j.neuron.2014.01.016 10.1016/j.cell.2014.06.017 10.1073/pnas.1221880110
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SubjectTerms	Autism Behavior Biomarkers Brain research Cancer Cancer therapies Humans Medical research Mental Disorders - diagnosis Mental Disorders - therapy Nervous System Diseases - diagnosis Nervous System Diseases - therapy Neurosciences Neurosciences - methods Neurosciences - trends Pharmaceutical industry Public-Private Sector Partnerships Regulatory approval Rodents Studies Translational Medical Research - methods Translational Medical Research - trends
Title	Public-Private Partnership: A New Engine for Translational Research in Neurosciences
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