Rapid generation of inducible mouse mutants

We have generated an optimized inducible recombination system for conditional gene targeting based on a Cre recombinase–steroid receptor fusion. This configuration allows efficient Cre‐mediated recombination in most organs of the mouse upon induction, without detectable background activity. An ES ce...

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Bibliographic Details
Published in:	Nucleic acids research Vol. 31; no. 4; p. e12
Main Authors:	Seibler, Jost, Zevnik, Branko, Küter‐Luks, Birgit, Andreas, Susanne, Kern, Heidrun, Hennek, Thomas, Rode, Anja, Heimann, Cornelia, Faust, Nicole, Kauselmann, Gunther, Schoor, Michael, Jaenisch, Rudolf, Rajewsky, Klaus, Kühn, Ralf, Schwenk, Frieder
Format:	Journal Article
Language:	English
Published:	England Oxford University Press 15-02-2003 Oxford Publishing Limited (England)
Subjects:	Animals Cell Line Embryo, Mammalian - cytology Embryo, Mammalian - metabolism Female Gene Expression Genetic Engineering - methods Humans Integrases - genetics Integrases - metabolism Male Mice Mice, Knockout - genetics Mice, Transgenic NAR Methods Online Receptors, Steroid - genetics Receptors, Steroid - metabolism Recombinant Fusion Proteins - genetics Recombinant Fusion Proteins - metabolism Recombination, Genetic Viral Proteins - genetics Viral Proteins - metabolism
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