Tumor-stroma biomechanical crosstalk: a perspective on the role of caveolin-1 in tumor progression

• Published in: Cancer and metastasis reviews Vol. 39; no. 2; pp. 485 - 503
• Main Authors: Lolo, Fidel Nicolás, Jiménez-Jiménez, Víctor, Sánchez-Álvarez, Miguel, del Pozo, Miguel Ángel
• Format: Journal Article
• Language: English
• Published: New York Springer US 01-06-2020; Springer; Springer Nature B.V
• Subjects: Animals; Antitumor agents; Biomechanics; Biomedical and Life Sciences; Biomedicine; Cancer Research; Cancer-Associated Fibroblasts - metabolism; Cancer-Associated Fibroblasts - pathology; Caveolae; Caveolin; Caveolin 1 - metabolism; Caveolin-1; Cell Communication - physiology; Disease Progression; Disease resistance; Extracellular matrix; Extracellular Matrix - metabolism; Extracellular Matrix - pathology; Fibroblasts; Health aspects; Humans; Malignancy; Mechanotransduction; Mechanotransduction, Cellular; Metastases; Metastasis; Neoplasms - metabolism; Neoplasms - pathology; Oncology; Receptor Cross-Talk; Stroma; Stromal Cells - metabolism; Stromal Cells - pathology; Tumor cells; Caveolin-1; Cell contraction; Caveolae; Stromal remodeling; YAP/TAZ; Mechanobiology; Extracellular matrix (ECM); Cancer-associated fibroblasts (CAFs); Metastasis; Integrin signaling; Tumor cell reprogramming; Cancer
• ISSN: 0167-7659; 1573-7233
• DOI: 10.1007/s10555-020-09900-y

Tumor stiffening is a hallmark of malignancy that actively drives tumor progression and aggressiveness. Recent research has shed light onto several molecular underpinnings of this biomechanical process, which has a reciprocal crosstalk between tumor cells, stromal fibroblasts, and extracellular matrix remodeling at its core. This dynamic communication shapes the tumor microenvironment; significantly determines disease features including therapeutic resistance, relapse, or metastasis; and potentially holds the key for novel antitumor strategies. Caveolae and their components emerge as integrators of different aspects of cell function, mechanotransduction, and ECM–cell interaction. Here, we review our current knowledge on the several pivotal roles of the essential caveolar component caveolin-1 in this multidirectional biomechanical crosstalk and highlight standing questions in the field.