Galanin receptor subtypes

The neuropeptide galanin, which is widely expressed in brain and peripheral tissues, exerts a broad range of physiological effects. Pharmacological studies using peptide analogues have led to speculation about multiple galanin receptor subtypes. Since 1994, a total of three G-protein-coupled recepto...

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Bibliographic Details
Published in:	Trends in Pharmacological Sciences Vol. 21; no. 3; pp. 109 - 117
Main Authors:	Branchek, Theresa A, Smith, Kelli E, Gerald, Christophe, Walker, Mary W
Format:	Book Review Journal Article
Language:	English
Published:	England Elsevier Ltd 01-03-2000
Subjects:	Amino Acid Sequence Animals Clone Cloning, Molecular GAL1 gal2 gal3 Galanin Galanin - pharmacology Humans Molecular Sequence Data Receptor Receptors, Galanin Receptors, Neuropeptide - classification Receptors, Neuropeptide - genetics Receptors, Neuropeptide - physiology Sequence Homology, Amino Acid gal2 gal3 Galanin Receptor Pharmacology GAL1 Clone
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Summary:	The neuropeptide galanin, which is widely expressed in brain and peripheral tissues, exerts a broad range of physiological effects. Pharmacological studies using peptide analogues have led to speculation about multiple galanin receptor subtypes. Since 1994, a total of three G-protein-coupled receptor (GPCR) subtypes for galanin have been cloned (GAL1, gal2 and gal3). Potent, selective antagonists are yet to be found for any of the cloned receptors. Major challenges in this field include linking the receptor clones with each of the known physiological actions of galanin and evaluating the evidence for additional galanin receptor subtypes.
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 ObjectType-Review-3 content type line 23 ObjectType-Feature-3 ObjectType-Review-1
ISSN:	0165-6147 1873-3735
DOI:	10.1016/S0165-6147(00)01446-2