Impact of intranasal budesonide on immune inflammatory responses and epithelial remodeling in chronic upper airway inflammation

Background: Histologic and immunohistologic features of nasal polyps (NP) are similar to those observed in asthma, thus suggesting a similar immunopathology. Objective: The primary objective of this study was to further understand the anti-inflammatory and immunoregulatory effects of locally deliver...

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Bibliographic Details
Published in:	Journal of allergy and clinical immunology Vol. 112; no. 1; pp. 37 - 44
Main Authors:	Mastruzzo, Claudio, Greco, Lucia Roberta, Nakano, Koichi, Nakano, Atsuko, Palermo, Filippo, Pistorio, Maria Provvidenza, Salinaro, Elisa Trovato, Jordana, Manel, Dolovich, Jerry, Crimi, †Nunzio, Vancheri, Carlo
Format:	Journal Article
Language:	English
Published:	New York, NY Mosby, Inc 01-07-2003 Elsevier Elsevier Limited
Subjects:	Administration, Intranasal Adult Allergies Asthma Biological and medical sciences budesonide Budesonide - administration & dosage CD4 T cells CD8 T cells Chronic Disease Cytokines - analysis Ent. Stomatology Eosinophils - drug effects Eosinophils - physiology epithelial remodeling Female Humans IL-4 IL-5 Immunohistochemistry Lymphocytes Male Medical sciences Middle Aged Nasal Mucosa - drug effects Nasal Mucosa - pathology Nasal Mucosa - physiopathology Nasal polyps Nasal Polyps - drug therapy Nasal Polyps - immunology Nasal Polyps - pathology Nose Pharmacology. Drug treatments Studies T-Lymphocyte Subsets - drug effects T-Lymphocyte Subsets - immunology TGF Transforming Growth Factor beta - analysis Transforming Growth Factor beta - physiology budesonide TGF NP epithelial remodeling IL-4 IL-5 CD4 T cells Nasal polyps CD8 T cells NM Budesonide Upper respiratory tract Transforming growth factor β Mucosa Route of administration Remodeling Nose T-Lymphocyte TGF-β Mechanism of action Polyp Human Corticosteroid Immune response Antiinflammatory agent Cytokine Immune regulation Inflammation Intranasal administration Epithelium Chemotherapy Treatment
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