Presence of pituitary adenylate cyclase-activating polypeptide (PACAP) in the plasma and milk of ruminant animals

• Published in: General and comparative endocrinology Vol. 172; no. 1; pp. 115 - 119
• Main Authors: Czegledi, Levente, Tamas, Andrea, Borzsei, Rita, Bagoly, Terez, Kiss, Peter, Horvath, Gabriella, Brubel, Reka, Nemeth, Jozsef, Szalontai, Balint, Szabadfi, Krisztina, Javor, Andras, Reglodi, Dora, Helyes, Zsuzsanna
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 15-05-2011
• Subjects: Animals; bioactive properties; Biopsy; blood serum; Breast milk; Cattle; cows; Data processing; Differentiation; Domestic animals; Endocrinology & Metabolism; ewe milk; Female; fluorescence; Goats; growth factors; Growth hormone; humans; Immunohistochemistry; lactating women; Lactation; Mammary gland; mammary glands; Mammary Glands, Animal - chemistry; Mammary Glands, Animal - metabolism; Mammary Glands, Animal - pathology; Milk; Milk - chemistry; Milk - metabolism; Neonates; Nerve growth factor; nerve tissue; Neuropeptides; nutritive value; PAC1 protein; Pituitary adenylate cyclase-activating polypeptide; Pituitary Adenylate Cyclase-Activating Polypeptide - analysis; Pituitary Adenylate Cyclase-Activating Polypeptide - blood; Pituitary Adenylate Cyclase-Activating Polypeptide - isolation & purification; Pituitary Adenylate Cyclase-Activating Polypeptide - metabolism; Plasma - chemistry; Plasma - metabolism; polypeptides; proteins; Radioimmunoassay; radioimmunoassays; Receptors, Pituitary Adenylate Cyclase-Activating Polypeptide, Type I - metabolism; Ruminantia; Ruminants - blood; Ruminants - metabolism; Serum; Sheep; somatotropin; Udder; Udder biopsy; udders; Immunohistochemistry; Udder biopsy; Serum; Radioimmunoassay; Milk
• ISSN: 0016-6480; 1095-6840
• DOI: 10.1016/j.ygcen.2010.12.012

Research highlights ► Pituitary adenylate cyclase-activating polypeptide (PACAP) is present in the milk of cow, sheep and goat. ► Concentrations of PACAP in the milk exceed those in corresponding plasma. ► PACAP immunoreactivity is present in udder biopsies. ► PAC1 receptor immunoreactivity is present in sheep mammary gland.