KATP channels are necessary for glucose-dependent increases in amyloid-β and Alzheimer's disease-related pathology

Elevated blood glucose levels, or hyperglycemia, can increase brain excitability and amyloid-β (Aβ) release, offering a mechanistic link between type 2 diabetes and Alzheimer's disease (AD). Since the cellular mechanisms governing this relationship are poorly understood, we explored whether ATP...

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Bibliographic Details
Published in:	JCI insight Vol. 8; no. 10
Main Authors:	Grizzanti, John, Moritz, William R, Pait, Morgan C, Stanley, Molly, Kaye, Sarah D, Carroll, Caitlin M, Constantino, Nicholas J, Deitelzweig, Lily J, Snipes, James A, Kellar, Derek, Caesar, Emily E, Pettit-Mee, Ryan J, Day, Stephen M, Sens, Jonathon P, Nicol, Noelle I, Dhillon, Jasmeen, Remedi, Maria S, Kiraly, Drew D, Karch, Celeste M, Nichols, Colin G, Holtzman, David M, Macauley, Shannon L
Format:	Journal Article
Language:	English
Published:	United States American Society for Clinical Investigation 22-05-2023 American Society for Clinical investigation
Subjects:	Aging Alzheimer Disease - pathology Amyloid beta-Peptides - metabolism Amyloid beta-Protein Precursor - metabolism Animals Diabetes Mellitus, Type 2 - complications Glucose Humans Hyperglycemia KATP Channels - metabolism Mice Neuroscience Aging Glucose metabolism Neuroscience Ion channels Alzheimer disease
Online Access:	Get full text
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