Synthesis, characterization and pharmacological screening of novel benzimidazole derivatives

In present study o-phenylenediamine and phenoxyacetic acid were used as starting material through series of steps 2-[2-(phenoxymethyl)-1H-benzimidazol-1-yl]acetohydrazide 5 was obtained. Various derivatives of 2-[2-(phenoxymethyl)-1H-benzimidazol-1-yl]-N′-[(Z)-phenylmethylidene]acetohydrazide and so...

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Published in:	Arabian journal of chemistry Vol. 9; no. S1; pp. S342 - S347
Main Authors:	Shaharyar, Mohammad, Mazumder, Avijit, Salahuddin, Garg, Ruchika, Pandey, Rishabh D
Format:	Journal Article
Language:	English
Published:	Elsevier B.V 01-09-2016 Elsevier
Subjects:	Anticonvulsant activity Benzimidazole Pharmacological screening Anticonvulsant activity Pharmacological screening Benzimidazole
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Abstract	In present study o-phenylenediamine and phenoxyacetic acid were used as starting material through series of steps 2-[2-(phenoxymethyl)-1H-benzimidazol-1-yl]acetohydrazide 5 was obtained. Various derivatives of 2-[2-(phenoxymethyl)-1H-benzimidazol-1-yl]-N′-[(Z)-phenylmethylidene]acetohydrazide and some compounds containing oxadiazole bearing benzimidazole were synthesized by using various aromatic aldehyde, cyanogens bromide and carbon disulfide/potassium hydroxide. These were elucidated by IR, NMR and elemental analysis and their in vivo anticonvulsant screening was performed using MES and scPTZ. Two compounds 7g and j were found to be potent in both the screens and their protective index was found to be better than standard drugs used.
AbstractList	In present study o-phenylenediamine and phenoxyacetic acid were used as starting material through series of steps 2-[2-(phenoxymethyl)-1H-benzimidazol-1-yl]acetohydrazide 5 was obtained. Various derivatives of 2-[2-(phenoxymethyl)-1H-benzimidazol-1-yl]-N′-[(Z)-phenylmethylidene]acetohydrazide and some compounds containing oxadiazole bearing benzimidazole were synthesized by using various aromatic aldehyde, cyanogens bromide and carbon disulfide/potassium hydroxide. These were elucidated by IR, NMR and elemental analysis and their in vivo anticonvulsant screening was performed using MES and scPTZ. Two compounds 7g and j were found to be potent in both the screens and their protective index was found to be better than standard drugs used.
Author	Mazumder, Avijit Garg, Ruchika Pandey, Rishabh D Shaharyar, Mohammad Salahuddin
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Cites_doi	10.1021/jm00305a079 10.1016/j.ejmech.2006.01.006 10.1016/j.ejmech.2008.01.022 10.1002/jps.2600680418 10.1021/jm00299a066 10.3390/51201429 10.1016/S0014-827X(01)01147-8 10.1007/s10593-006-0135-x 10.1016/S0223-5234(01)01313-7 10.1021/jm0510373 10.1016/0223-5234(96)89560-2 10.1016/j.bmcl.2006.10.071 10.18388/abp.2002_3835 10.1007/BF00758335 10.1021/jm00121a019 10.1021/jm00372a013
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Keywords	Anticonvulsant activity Pharmacological screening Benzimidazole
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Title	Synthesis, characterization and pharmacological screening of novel benzimidazole derivatives
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