Genetic separation of FK506 susceptibility and drug transport in the yeast Pdr5 ATP-binding cassette multidrug resistance transporter

Overexpression of the yeast Pdr5 ATP-binding cassette transporter leads to pleiotropic drug resistance to a variety of structurally unrelated cytotoxic compounds. To identify Pdr5 residues involved in substrate recognition and/or drug transport, we used a combination of random in vitro mutagenesis a...

Full description

Saved in:

Bibliographic Details
Published in:	Molecular biology of the cell Vol. 9; no. 2; pp. 523 - 543
Main Authors:	Egner, R, Rosenthal, F E, Kralli, A, Sanglard, D, Kuchler, K
Format:	Journal Article
Language:	English
Published:	United States The American Society for Cell Biology 01-02-1998
Subjects:	Amino Acid Sequence Amino Acid Substitution Antifungal Agents - pharmacology ATP-Binding Cassette Transporters - antagonists & inhibitors ATP-Binding Cassette Transporters - chemistry ATP-Binding Cassette Transporters - genetics Biological Transport Carrier Proteins - genetics Carrier Proteins - physiology Cell Membrane - chemistry Cloning, Molecular Cycloheximide - pharmacology Dexamethasone - metabolism Dexamethasone - pharmacology DNA-Binding Proteins - genetics DNA-Binding Proteins - physiology Drug Resistance, Microbial - genetics Drug Resistance, Multiple - genetics Estradiol - metabolism Gene Expression - drug effects Heat-Shock Proteins - genetics Heat-Shock Proteins - physiology Membrane Proteins - antagonists & inhibitors Membrane Proteins - chemistry Membrane Proteins - genetics Molecular Sequence Data Mutagenesis Rhodamine 123 Rhodamines - metabolism Rhodamines - pharmacology Saccharomyces cerevisiae - drug effects Saccharomyces cerevisiae - genetics Saccharomyces cerevisiae Proteins Sequence Alignment Substrate Specificity Tacrolimus - pharmacology Tacrolimus Binding Proteins
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Be the first to leave a comment!