Role of the mechanisms for antibody repertoire diversification in monoclonal light chain deposition disorders: when a friend becomes foe

The adaptive immune system of jawed vertebrates generates a highly diverse repertoire of antibodies to meet the antigenic challenges of a constantly evolving biological ecosystem. Most of the diversity is generated by two mechanisms: V(D)J gene recombination and somatic hypermutation (SHM). SHM intr...

Full description

Saved in:

Bibliographic Details
Published in:	Frontiers in immunology Vol. 14; p. 1203425
Main Authors:	Del Pozo-Yauner, Luis, Herrera, Guillermo A, Perez Carreon, Julio I, Turbat-Herrera, Elba A, Rodriguez-Alvarez, Francisco J, Ruiz Zamora, Robin A
Format:	Journal Article
Language:	English
Published:	Switzerland Frontiers Media S.A 13-07-2023
Subjects:	amyloid Animals B-Lymphocytes Ecosystem Friends Humans immune system Immunology light chain (AL) amyloidosis Multiple Myeloma Paraproteinemias - genetics protein aggregation somatic hypermutation V(D)J rearrangement amyloid somatic hypermutation protein aggregation immune system V(D)J rearrangement antibodies light chain (AL) amyloidosis
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Be the first to leave a comment!