Prognostic impact of the cross-sectional area of the erector spinae muscle in patients with pleuroparenchymal fibroelastosis

• Published in: Scientific reports Vol. 13; no. 1; p. 17289
• Main Authors: Kitahara, Shinsuke, Abe, Mitsuhiro, Kono, Chiyoko, Sakuma, Noriko, Ishii, Daisuke, Kawasaki, Takeshi, Ikari, Jun, Suzuki, Takuji
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 12-10-2023; Nature Publishing Group; Nature Portfolio
• Subjects: 692/308; 692/499; 692/699; Activities of daily living; Atrophy; Body mass index; Cachexia; Chronic obstructive pulmonary disease; Fibrosis; Humanities and Social Sciences; Lung diseases; Mortality; multidisciplinary; Multivariate analysis; Musculoskeletal system; Obstructive lung disease; Prognosis; Science; Science (multidisciplinary); Skeletal muscle
• ISSN: 2045-2322; 2045-2322
• DOI: 10.1038/s41598-023-44138-y

Pleuroparenchymal fibroelastosis (PPFE) progresses slowly but sometimes relatively quickly, leading to decreased activities of daily living (ADL) and muscle weakness. Skeletal muscle atrophy and muscle weakness in chronic obstructive pulmonary disease (COPD) patients may be caused by cachexia and are associated with reduced ADLs and increased risk of death. However, the association between skeletal muscle mass and the prognosis of PPFE patients remains unknown. We retrospectively analysed the clinical significance of the cross-sectional area of the erector spinae muscle (ESM
CSA
), a skeletal muscle index, and predictors of mortality within 3 years in PPFE 51 patients, idiopathic pulmonary fibrosis (IPF) 52 patients and COPD 62 patients. PPFE patients had significantly lower ESM
CSA
than IPF or COPD patients, and lower ESM
CSA
(< 22.57 cm
2
) was associated with prognosis within 3 years (log-rank test; p = 0.006), whereas lower body mass index (BMI) showed no association. Multivariate analysis showed that ESM
CSA
was an independent predictor of mortality within 3 years in PPFE patients (hazard ratio, 0.854; 95% confidence interval: 0.737–0.990, p = 0.036). These results suggest the importance of monitoring ESM
CSA
in PPFE patients and that assessing ESM
CSA
in PPFE patients could be a more useful prognostic indicator than BMI.