Systemic administration of vitamins C and E attenuates nociception induced by chronic constriction injury of the sciatic nerve in rats

• Published in: Brain research bulletin Vol. 121; pp. 169 - 177
• Main Authors: Riffel, Ana Paula K, de Souza, Jéssica A, Santos, Maria do Carmo Q, Horst, Andréa, Scheid, Taína, Kolberg, Carolina, Belló-Klein, Adriane, Partata, Wania A
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01-03-2016
• Subjects: Alanine Transaminase - metabolism; Analgesics - therapeutic use; Analysis of Variance; Animals; Antioxidant; Antioxidants - metabolism; Ascorbic Acid - administration & dosage; Aspartate Aminotransferases - metabolism; Constriction; Disease Models, Animal; gamma-Glutamyltransferase - metabolism; Hyperalgesia - drug therapy; Hyperalgesia - physiopathology; Lipid peroxidation; Locomotion - drug effects; Male; Mechanical threshold; Neurology; Nociception - drug effects; Oxidative stress; Pain Measurement; Pain Threshold - drug effects; Physical Stimulation - adverse effects; Rats; Rats, Wistar; Sciatic functional index; Sciatica - drug therapy; Sciatica - etiology; Thermal threshold; Time Factors; Vitamin E - administration & dosage; Lipid peroxidation; Sciatic functional index; Oxidative stress; Thermal threshold; Antioxidant; Mechanical threshold
• ISSN: 0361-9230; 1873-2747
• DOI: 10.1016/j.brainresbull.2016.02.004

Highlights • Vitamin C and E increase thermal and mechanical thresholds in CCI rats. • Antinociceptive effect of vitamin C and E and vitamin C + E in CCI rats. • Vitamin C and E and vitamin C + E ameliorate sciatic functional index in CCI rats. • Highest antinociception with co-administration of vitamin C + E and gabapentin.