Fusion of HMGA1 to the LPP/TPRG1 intergenic region in a lipoma identified by mapping paraffin-embedded tissues

• Published in: Cancer genetics and cytogenetics Vol. 196; no. 1; pp. 64 - 67
• Main Authors: Wang, Xiaoke, Zamolyi, Renata Q, Zhang, Hongying, Pannain, Vera L, Medeiros, Fabiola, Erickson-Johnson, Michele, Jenkins, Robert B, Oliveira, Andre M
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 2010
• Subjects: Cytoskeletal Proteins - genetics; Female; Gene Fusion; Hematology, Oncology and Palliative Medicine; HMGA1a Protein - genetics; Humans; LIM Domain Proteins; Lipoma - genetics; Medical Education; Middle Aged; Paraffin Embedding; Proteins - genetics
• ISSN: 0165-4608; 1873-4456
• DOI: 10.1016/j.cancergencyto.2009.09.003

Abstract Ordinary lipoma frequently harbors rearrangement of HMGA2. LPP is the most common partner gene to HMGA2 , but has not been seen fused to HMGA1 . We report the fusion of HMGA1 to the intergenic region between LPP and TPRG1 in a lipoma. Conventional cytogenetic analysis of an abdominal-wall lipoma diagnosed in a 60-year-old woman showed a t(3;6)(q27;p21). Molecular cytogenetic mapping of available paraffin-embedded tissues revealed the fusion of HMGA1 to a 139-kb genomic region between the LPP and TPRG1 loci. No rearrangement of HMGA2 was found. The biological function of this novel fusion could be similar to the role of HMGA2–LPP in tumorigenesis.