Two New Fluorogenic Aptasensors Based on Capped Mesoporous Silica Nanoparticles to Detect Ochratoxin A
Aptamers have been used as recognition elements for several molecules due to their great affinity and selectivity. Additionally, mesoporous nanomaterials have demonstrated great potential in sensing applications. Based on these concepts, we report herein the use of two aptamer‐capped mesoporous sili...
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| Published in: | ChemistryOpen (Weinheim) Vol. 6; no. 5; pp. 653 - 659 |
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01-10-2017
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| Abstract | Aptamers have been used as recognition elements for several molecules due to their great affinity and selectivity. Additionally, mesoporous nanomaterials have demonstrated great potential in sensing applications. Based on these concepts, we report herein the use of two aptamer‐capped mesoporous silica materials for the selective detection of ochratoxin A (OTA). A specific aptamer for OTA was used to block the pores of rhodamine B‐loaded mesoporous silica nanoparticles. Two solids were prepared in which the aptamer capped the porous scaffolds by using a covalent or electrostatic approach. Whereas the prepared materials remained capped in water, dye delivery was selectively observed in the presence of OTA. The protocol showed excellent analytical performance in terms of sensitivity (limit of detection: 0.5–0.05 nm), reproducibility, and selectivity. Moreover, the aptasensors were tested for OTA detection in commercial foodstuff matrices, which demonstrated their potential applicability in real samples.
Pop the cap: Two new fluorogenic aptasensors based on capped mesoporous silica nanoparticles for the detection of ochratoxin A (OTA) are prepared. The presence of OTA induces displacement of the aptamer from the solid surface, opens the pores, and selectively releases dye (see figure). These new capped nanomaterials allow accurate determination of OTA in realistic wheat samples and may allow the development of a simple test for the detection of OTA in food samples. |
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| AbstractList | Aptamers have been used as recognition elements for several molecules due to their great affinity and selectivity. Additionally, mesoporous nanomaterials have demonstrated great potential in sensing applications. Based on these concepts, we report herein the use of two aptamer-capped mesoporous silica materials for the selective detection of ochratoxin A (OTA). A specific aptamer for OTA was used to block the pores of rhodamine B-loaded mesoporous silica nanoparticles. Two solids were prepared in which the aptamer capped the porous scaffolds by using a covalent or electrostatic approach. Whereas the prepared materials remained capped in water, dye delivery was selectively observed in the presence of OTA. The protocol showed excellent analytical performance in terms of sensitivity (limit of detection: 0.5–0.05 nm), reproducibility, and selectivity. Moreover, the aptasensors were tested for OTA detection in commercial foodstuff matrices, which demonstrated their potential applicability in real samples. Aptamers have been used as recognition elements for several molecules due to their great affinity and selectivity. Additionally, mesoporous nanomaterials have demonstrated great potential in sensing applications. Based on these concepts, we report herein the use of two aptamer‐capped mesoporous silica materials for the selective detection of ochratoxin A (OTA). A specific aptamer for OTA was used to block the pores of rhodamine B‐loaded mesoporous silica nanoparticles. Two solids were prepared in which the aptamer capped the porous scaffolds by using a covalent or electrostatic approach. Whereas the prepared materials remained capped in water, dye delivery was selectively observed in the presence of OTA. The protocol showed excellent analytical performance in terms of sensitivity (limit of detection: 0.5–0.05 n m ), reproducibility, and selectivity. Moreover, the aptasensors were tested for OTA detection in commercial foodstuff matrices, which demonstrated their potential applicability in real samples. Aptamers have been used as recognition elements for several molecules due to their great affinity and selectivity. Additionally, mesoporous nanomaterials have demonstrated great potential in sensing applications. Based on these concepts, we report herein the use of two aptamer‐capped mesoporous silica materials for the selective detection of ochratoxin A (OTA). A specific aptamer for OTA was used to block the pores of rhodamine B‐loaded mesoporous silica nanoparticles. Two solids were prepared in which the aptamer capped the porous scaffolds by using a covalent or electrostatic approach. Whereas the prepared materials remained capped in water, dye delivery was selectively observed in the presence of OTA. The protocol showed excellent analytical performance in terms of sensitivity (limit of detection: 0.5–0.05 nm), reproducibility, and selectivity. Moreover, the aptasensors were tested for OTA detection in commercial foodstuff matrices, which demonstrated their potential applicability in real samples. Pop the cap: Two new fluorogenic aptasensors based on capped mesoporous silica nanoparticles for the detection of ochratoxin A (OTA) are prepared. The presence of OTA induces displacement of the aptamer from the solid surface, opens the pores, and selectively releases dye (see figure). These new capped nanomaterials allow accurate determination of OTA in realistic wheat samples and may allow the development of a simple test for the detection of OTA in food samples. |
| Author | Aznar, Elena Marcos, M. Dolores Sancenón, Félix Martínez‐Máñez, Ramón Ribes, Àngela Bernardos, Andrea Pardo, Teresa Santiago‐Felipe, Sara |
| AuthorAffiliation | 1 Instituto Interuniversitario de Investigación de Reconocimiento Molecular y Desarrollo Tecnológico, Universitat Politècnica de València Universitat de València Camino de Vera s/n 46022 Valencia Spain 3 Unidad Mixta de Investigación en Nanomedicina y Sensores Universitat Politècnica de València, Instituto de Investigación Sanitaria La Fe 46022 Valencia Spain 4 Unidad Mixta UPV-CIPF de Investigación en Mecanismos de Enfermedades y Nanomedicina Universitat Politècnica de València, Centro de Investigación Príncipe Felipe 46022 Valencia Spain 2 CIBER de Bioingeniería Biomateriales y Nanomedicina (CIBER-BBN) 50018 Zaragoza Spain |
| AuthorAffiliation_xml | – name: 1 Instituto Interuniversitario de Investigación de Reconocimiento Molecular y Desarrollo Tecnológico, Universitat Politècnica de València Universitat de València Camino de Vera s/n 46022 Valencia Spain – name: 2 CIBER de Bioingeniería Biomateriales y Nanomedicina (CIBER-BBN) 50018 Zaragoza Spain – name: 3 Unidad Mixta de Investigación en Nanomedicina y Sensores Universitat Politècnica de València, Instituto de Investigación Sanitaria La Fe 46022 Valencia Spain – name: 4 Unidad Mixta UPV-CIPF de Investigación en Mecanismos de Enfermedades y Nanomedicina Universitat Politècnica de València, Centro de Investigación Príncipe Felipe 46022 Valencia Spain |
| Author_xml | – sequence: 1 givenname: Àngela orcidid: 0000-0001-9542-302X surname: Ribes fullname: Ribes, Àngela organization: Universitat Politècnica de València, Instituto de Investigación Sanitaria La Fe – sequence: 2 givenname: Sara orcidid: 0000-0002-1731-815X surname: Santiago‐Felipe fullname: Santiago‐Felipe, Sara organization: Universitat Politècnica de València, Instituto de Investigación Sanitaria La Fe – sequence: 3 givenname: Andrea orcidid: 0000-0002-3842-5771 surname: Bernardos fullname: Bernardos, Andrea organization: Universitat Politècnica de València, Centro de Investigación Príncipe Felipe – sequence: 4 givenname: M. Dolores orcidid: 0000-0001-7079-8589 surname: Marcos fullname: Marcos, M. Dolores organization: Universitat Politècnica de València, Centro de Investigación Príncipe Felipe – sequence: 5 givenname: Teresa surname: Pardo fullname: Pardo, Teresa organization: Universitat Politècnica de València, Centro de Investigación Príncipe Felipe – sequence: 6 givenname: Félix orcidid: 0000-0002-5205-7135 surname: Sancenón fullname: Sancenón, Félix organization: Universitat Politècnica de València, Centro de Investigación Príncipe Felipe – sequence: 7 givenname: Ramón orcidid: 0000-0001-5873-9674 surname: Martínez‐Máñez fullname: Martínez‐Máñez, Ramón email: rmaez@qim.upv.es organization: Universitat Politècnica de València, Centro de Investigación Príncipe Felipe – sequence: 8 givenname: Elena orcidid: 0000-0003-0361-3876 surname: Aznar fullname: Aznar, Elena organization: Universitat Politècnica de València, Centro de Investigación Príncipe Felipe |
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| Keywords | ochratoxin A sensors aptamers nanostructures mesoporous materials |
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| Snippet | Aptamers have been used as recognition elements for several molecules due to their great affinity and selectivity. Additionally, mesoporous nanomaterials have... |
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| SubjectTerms | aptamers Materials selection mesoporous materials Nanomaterials Nanoparticles nanostructures ochratoxin A Porous materials Reproducibility Scaffolds Selectivity Sensitivity analysis sensors Silica Silicon dioxide |
| Title | Two New Fluorogenic Aptasensors Based on Capped Mesoporous Silica Nanoparticles to Detect Ochratoxin A |
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