Risk of Death in Dual-eligible Nursing Home Residents Using Typical or Atypical Antipsychotic Agents
Background: Antipsychotic use among dual-eligible nursing home residents is a concern for cost and safety considerations. Objective: To examine the comparative risk of death in dual-eligible elderly nursing home residents using typical and atypical agents. Methods: A retrospective cohort design matc...
Saved in:
| Published in: | Medical care Vol. 50; no. 11; pp. 961 - 969 |
|---|---|
| Main Authors: | , , , |
| Format: | Journal Article |
| Language: | English |
| Published: |
United States
Lippincott Williams & Wilkins
01-11-2012
Lippincott Williams & Wilkins, Inc Lippincott Williams & Wilkins Ovid Technologies |
| Subjects: | |
| Online Access: | Get full text |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| Abstract | Background: Antipsychotic use among dual-eligible nursing home residents is a concern for cost and safety considerations. Objective: To examine the comparative risk of death in dual-eligible elderly nursing home residents using typical and atypical agents. Methods: A retrospective cohort design matched on propensity score was used to examine the risk of death due to antipsychotic use among dual-eligible nursing home residents 65 years or older from four states. New typical and atypical users in nursing homes were followed for 6 months after the exposure without any censoring. The risk of death was modeled using the Cox proportional model and the extended Cox hazard model stratified on matched pairs based on propensity score. Results: The unadjusted mortality rate was 18.42% for atypical antipsychotic users and 24.06% for typical antipsychotic users. The Cox proportional-hazards regression model revealed significant increased risk of death [hazard ratio (HR), 1.41; 95% confidence interval (CI), 1.27-1.57] among typical users when compared with atypical users. The extended Cox model, used due to the violation of proportional hazards assumption, revealed that risk of death was nearly twice as great among typical antipsychotic users within 40 days of antipsychotic treatment (HR, 1.81; 95% CI, 1.49-2.18) when compared with atypical users. However, moderate increase in risk (HR, 1.24; 95% CI, 1.09-1.42] was observed for 40-180 days of typical antipsychotic exposure. Conclusions: The use of typical antipsychotic agents was associated with highest risk of all-cause mortality within 40 days of typical antipsychotic use when compared with atypical use, and the risk decreased after 40 days among dual-eligible elderly nursing home residents. |
|---|---|
| AbstractList | Background: Antipsychotic use among dual-eligible nursing home residents is a concern for cost and safety considerations. Objective: To examine the comparative risk of death in dual-eligible elderly nursing home residents using typical and atypical agents. Methods: A retrospective cohort design matched on propensity score was used to examine the risk of death due to antipsychotic use among dual-eligible nursing home residents 65 years or older from four states. New typical and atypical users in nursing homes were followed for 6 months after the exposure without any censoring. The risk of death was modeled using the Cox proportional model and the extended Cox hazard model stratified on matched pairs based on propensity score. Results: The unadjusted mortality rate was 18.42% for atypical antipsychotic users and 24.06% for typical antipsychotic users. The Cox proportional-hazards regression model revealed significant increased risk of death [hazard ratio (HR), 1.41; 95% confidence interval (CI), 1.27-1.57] among typical users when compared with atypical users. The extended Cox model, used due to the violation of proportional hazards assumption, revealed that risk of death was nearly twice as great among typical antipsychotic users within 40 days of antipsychotic treatment (HR, 1.81; 95% CI, 1.49-2.18) when compared with atypical users. However, moderate increase in risk (HR, 1.24; 95% CI, 1.09-1.42] was observed for 40-180 days of typical antipsychotic exposure. Conclusions: The use of typical antipsychotic agents was associated with highest risk of all-cause mortality within 40 days of typical antipsychotic use when compared with atypical use, and the risk decreased after 40 days among dual-eligible elderly nursing home residents. BACKGROUND:Antipsychotic use among dual-eligible nursing home residents is a concern for cost and safety considerations. OBJECTIVE:To examine the comparative risk of death in dual-eligible elderly nursing home residents using typical and atypical agents. METHODS:A retrospective cohort design matched on propensity score was used to examine the risk of death due to antipsychotic use among dual-eligible nursing home residents 65 years or older from four states. New typical and atypical users in nursing homes were followed for 6 months after the exposure without any censoring. The risk of death was modeled using the Cox proportional model and the extended Cox hazard model stratified on matched pairs based on propensity score. RESULTS:The unadjusted mortality rate was 18.42% for atypical antipsychotic users and 24.06% for typical antipsychotic users. The Cox proportional-hazards regression model revealed significant increased risk of death [hazard ratio (HR), 1.41; 95% confidence interval (CI), 1.27–1.57] among typical users when compared with atypical users. The extended Cox model, used due to the violation of proportional hazards assumption, revealed that risk of death was nearly twice as great among typical antipsychotic users within 40 days of antipsychotic treatment (HR, 1.81; 95% CI, 1.49–2.18) when compared with atypical users. However, moderate increase in risk (HR, 1.24; 95% CI, 1.09–1.42] was observed for 40–180 days of typical antipsychotic exposure. CONCLUSIONS:The use of typical antipsychotic agents was associated with highest risk of all-cause mortality within 40 days of typical antipsychotic use when compared with atypical use, and the risk decreased after 40 days among dual-eligible elderly nursing home residents. Antipsychotic use among dual-eligible nursing home residents is a concern for cost and safety considerations. To examine the comparative risk of death in dual-eligible elderly nursing home residents using typical and atypical agents. A retrospective cohort design matched on propensity score was used to examine the risk of death due to antipsychotic use among dual-eligible nursing home residents 65 years or older from four states. New typical and atypical users in nursing homes were followed for 6 months after the exposure without any censoring. The risk of death was modeled using the Cox proportional model and the extended Cox hazard model stratified on matched pairs based on propensity score. The unadjusted mortality rate was 18.42% for atypical antipsychotic users and 24.06% for typical antipsychotic users. The Cox proportional-hazards regression model revealed significant increased risk of death [hazard ratio (HR), 1.41; 95% confidence interval (CI), 1.27-1.57] among typical users when compared with atypical users. The extended Cox model, used due to the violation of proportional hazards assumption, revealed that risk of death was nearly twice as great among typical antipsychotic users within 40 days of antipsychotic treatment (HR, 1.81; 95% CI, 1.49-2.18) when compared with atypical users. However, moderate increase in risk (HR, 1.24; 95% CI, 1.09-1.42] was observed for 40-180 days of typical antipsychotic exposure. The use of typical antipsychotic agents was associated with highest risk of all-cause mortality within 40 days of typical antipsychotic use when compared with atypical use, and the risk decreased after 40 days among dual-eligible elderly nursing home residents. BACKGROUNDAntipsychotic use among dual-eligible nursing home residents is a concern for cost and safety considerations.OBJECTIVETo examine the comparative risk of death in dual-eligible elderly nursing home residents using typical and atypical agents.METHODSA retrospective cohort design matched on propensity score was used to examine the risk of death due to antipsychotic use among dual-eligible nursing home residents 65 years or older from four states. New typical and atypical users in nursing homes were followed for 6 months after the exposure without any censoring. The risk of death was modeled using the Cox proportional model and the extended Cox hazard model stratified on matched pairs based on propensity score.RESULTSThe unadjusted mortality rate was 18.42% for atypical antipsychotic users and 24.06% for typical antipsychotic users. The Cox proportional-hazards regression model revealed significant increased risk of death [hazard ratio (HR), 1.41; 95% confidence interval (CI), 1.27-1.57] among typical users when compared with atypical users. The extended Cox model, used due to the violation of proportional hazards assumption, revealed that risk of death was nearly twice as great among typical antipsychotic users within 40 days of antipsychotic treatment (HR, 1.81; 95% CI, 1.49-2.18) when compared with atypical users. However, moderate increase in risk (HR, 1.24; 95% CI, 1.09-1.42] was observed for 40-180 days of typical antipsychotic exposure.CONCLUSIONSThe use of typical antipsychotic agents was associated with highest risk of all-cause mortality within 40 days of typical antipsychotic use when compared with atypical use, and the risk decreased after 40 days among dual-eligible elderly nursing home residents. Antipsychotic use among dual-eligible nursing home residents is a concern for cost and safety considerations. To examine the comparative risk of death in dual-eligible elderly nursing home residents using typical and atypical agents. A retrospective cohort design matched on propensity score was used to examine the risk of death due to antipsychotic use among dual-eligible nursing home residents 65 years or older from four states. New typical and atypical users in nursing homes were followed for 6 months after the exposure without any censoring. The risk of death was modeled using the Cox proportional model and the extended Cox hazard model stratified on matched pairs based on propensity score. The unadjusted mortality rate was 18.42% for atypical antipsychotic users and 24.06% for typical antipsychotic users. The Cox proportional-hazards regression model revealed significant increased risk of death [hazard ratio (HR), 1.41; 95% confidence interval (CI), 1.27-1.57] among typical users when compared with atypical users. The extended Cox model, used due to the violation of proportional hazards assumption, revealed that risk of death was nearly twice as great among typical antipsychotic users within 40 days of antipsychotic treatment (HR, 1.81; 95% CI, 1.49-2.18) when compared with atypical users. However, moderate increase in risk (HR, 1.24; 95% CI, 1.09-1.42] was observed for 40-180 days of typical antipsychotic exposure. The use of typical antipsychotic agents was associated with highest risk of all-cause mortality within 40 days of typical antipsychotic use when compared with atypical use, and the risk decreased after 40 days among dual-eligible elderly nursing home residents. |
| Author | Aparasu, Rajender R. Chatterjee, Satabdi Mehta, Sandhya Chen, Hua |
| AuthorAffiliation | Department of Clinical Sciences and Administration, College of Pharmacy, University of Houston, Texas Medical Center, Houston, TX |
| AuthorAffiliation_xml | – name: Department of Clinical Sciences and Administration, College of Pharmacy, University of Houston, Texas Medical Center, Houston, TX |
| Author_xml | – sequence: 1 givenname: Rajender R. surname: Aparasu fullname: Aparasu, Rajender R. – sequence: 2 givenname: Satabdi surname: Chatterjee fullname: Chatterjee, Satabdi – sequence: 3 givenname: Sandhya surname: Mehta fullname: Mehta, Sandhya – sequence: 4 givenname: Hua surname: Chen fullname: Chen, Hua |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/23047786$$D View this record in MEDLINE/PubMed |
| BookMark | eNpdkd1qGzEQhUVJaZy0b9AWQW56s-noX740SdsU3BZMcr3syrO2HHnlSrsEv33l2k0hgkHScM7HYeaCnPWxR0LeM7hmMDWff8wX19ACEyiY5Rods-oVmTAlTMWm0p6RCQBXlQEzPScXOW8AmBGKvyHnXIA0xuoJWS58fqSxo7fYDGvqe3o7NqHC4Fe-DUh_jin7fkXv4hbpArNfYj9k-vC3eb_fedcEGhOdDaf3rB_8Lu_dOg7e0dnqIH9LXndNyPjudF-Sh69f7m_uqvmvb99vZvPKSW2hmiotjYNWay1Rd3rZoUPeKmuhRSW5VK10GnBqtRTctaI1qlMNa0BKVFyJS_LpyN2l-HvEPNRbnx2G0PQYx1yXuSnLOOO2SK9eSDdxTH1JVzPGOBdSaCgqeVS5FHNO2NW75LdN2hfUgWbqsoX65RaK7eMJPrZbXD6b_o39P_cphgFTfgzjE6Z6jU0Y1jWUo7SCikMJy8qvKsUOcT4cbZs8xPSMlcwwqUGLP0eDnUk |
| CODEN | MELAAD |
| CitedBy_id | crossref_primary_10_1345_aph_1R510 crossref_primary_10_1002_pds_3819 crossref_primary_10_1371_journal_pone_0105376 crossref_primary_10_1016_j_sapharm_2013_10_003 crossref_primary_10_1186_s40360_017_0183_0 crossref_primary_10_1002_phar_1898 crossref_primary_10_1016_j_psc_2016_01_008 crossref_primary_10_1016_j_sapharm_2018_08_015 crossref_primary_10_1002_gps_5106 crossref_primary_10_1016_j_jpor_2018_04_003 crossref_primary_10_1080_17425255_2019_1561860 crossref_primary_10_1176_appi_ps_201300093 crossref_primary_10_2217_cer_2016_0009 crossref_primary_10_1111_jgs_13326 crossref_primary_10_3233_JAD_160671 crossref_primary_10_1007_s40264_014_0170_y crossref_primary_10_1176_appi_ps_201500011 crossref_primary_10_1016_j_jamda_2021_02_027 crossref_primary_10_1111_jcpt_12099 crossref_primary_10_1002_pds_3912 crossref_primary_10_1080_13607863_2017_1286451 crossref_primary_10_1111_jgs_12939 crossref_primary_10_1007_s40801_015_0013_x |
| Cites_doi | 10.7326/0003-4819-146-11-200706050-00006 10.1080/10673220500433247 10.4088/JCP.08m04597yel 10.1001/jama.294.15.1934 10.1503/cmaj.061250 10.1111/j.1532-5415.2005.00566.x 10.5034/inquiryjrnl_42.2.171 10.1001/archpsyc.58.12.1161 10.1001/archinte.1997.00440390083011 10.1017/S1041610205002243 10.1097/01.JGP.0000200589.01396.6d 10.1016/j.amjopharm.2006.09.011 10.1093/aje/kwj149 10.3310/hta7130 10.1001/archinte.168.10.1090 10.2202/1557-4679.1146 10.2307/2532304 10.1056/NEJMoa052827 10.1111/j.1524-4733.2006.00130.x 10.1097/JGP.0b013e31819b8936 10.1016/j.amjopharm.2008.10.003 10.1097/JGP.0b013e31802d0b00 10.1080/00048670701519864 10.1176/ps.2007.58.11.1400 |
| ContentType | Journal Article |
| Copyright | Copyright © 2012 Lippincott Williams & Wilkins 2012 Lippincott Williams & Wilkins, Inc. Copyright Lippincott Williams & Wilkins Nov 2012 |
| Copyright_xml | – notice: Copyright © 2012 Lippincott Williams & Wilkins – notice: 2012 Lippincott Williams & Wilkins, Inc. – notice: Copyright Lippincott Williams & Wilkins Nov 2012 |
| DBID | CGR CUY CVF ECM EIF NPM AAYXX CITATION K9. 7X8 |
| DOI | 10.1097/MLR.0b013e31826ec185 |
| DatabaseName | Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed CrossRef ProQuest Health & Medical Complete (Alumni) MEDLINE - Academic |
| DatabaseTitle | MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) CrossRef ProQuest Health & Medical Complete (Alumni) MEDLINE - Academic |
| DatabaseTitleList | MEDLINE MEDLINE - Academic ProQuest Health & Medical Complete (Alumni) |
| Database_xml | – sequence: 1 dbid: ECM name: MEDLINE url: https://search.ebscohost.com/login.aspx?direct=true&db=cmedm&site=ehost-live sourceTypes: Index Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Medicine Public Health |
| EISSN | 1537-1948 |
| EndPage | 969 |
| ExternalDocumentID | 2789648431 10_1097_MLR_0b013e31826ec185 23047786 00005650-201211000-00010 41714606 |
| Genre | Research Support, U.S. Gov't, P.H.S Journal Article Feature |
| GeographicLocations | United States |
| GeographicLocations_xml | – name: United States |
| GroupedDBID | --- -~X .-D ..I .Z2 01R 0R~ 1J1 3R3 40H 4Q1 4Q2 4Q3 53G 5GY 5VS 63O 71W 77Y 7O~ 8L- AAAXR AAGIX AAHPQ AAKYL AAMOA AAMTA AARTV AASOK AAWTL AAWTO AAXQO AAYEP ABBHK ABBUW ABDIG ABIVO ABJNI ABPPZ ABQDR ABXSQ ABXVJ ABZAD ACCJW ACDDN ACEWG ACGFO ACGFS ACHQT ACILI ACNWC ACWDW ACWRI ACXNZ ADGGA ADHPY ADNKB ADULT AE3 AE6 AEETU AELLO AENEX AEUPB AFDTB AFRAH AFUWQ AGINI AHMBA AHOMT AHVBC AIJEX AINUH AJIOK AJNWD AJNYG AKBRZ ALMA_UNASSIGNED_HOLDINGS AMJPA AMNEI AWKKM BDTQF BHOJU BOYCO BQLVK C45 CS3 DIWNM DU5 DUNZO E.X EBS EJD EX3 F2K F2L F2M F2N F5P FCALG FL- FW0 H0~ HZ~ H~9 IH2 IKREB IKYAY IN~ JAA JAAYA JBMMH JBZCM JENOY JF9 JG8 JHFFW JK3 JK8 JKQEH JLEZI JLXEF JPL JSODD JST KD2 KMI L-C L7B N9A N~7 N~B O9- OAG OAH ODA ODZKP OJAPA OL1 OLG OLH OLL OLU OLV OLW OLY OLZ OPUJH OPX OUVQU OVD OVDNE OVIDH OVLEI OWBYB OWU OWV OWW OWX OWY OWZ OXXIT P-O P2P PQQKQ RLZ S4R S4S SA0 TEORI TN5 V2I VQP VVN W3M WH7 WOQ WOW X3V X3W XFW XXN XYM YCJ YFH YOC ZA5 ZFV ZY1 ZZMQN .3C .GJ 08R AAPBV AAQKA AAQQT ABASU ACLED ADFPA AHRYX AJRGT AKALU AKULP ALMTX AMKUR AOHHW BS7 EEVPB GIFXF GNXGY GQDEL HGD IPNFZ K8S N4W N~M OCUKA ORVUJ P-K QZG R58 RIG T8P TSPGW YHZ ZGI ZXP AAAAV AAIQE AASCR ABVCZ ACDIW ACLDA ACXJB ADACV AHQNM AJZMW CGR CUY CVF ECM EIF ERAAH HLJTE HVGLF IPSME NPM AAYXX CITATION K9. 7X8 |
| ID | FETCH-LOGICAL-c4680-95647c0b6664e6f6dfece2b5880be54245b4c60e986432cb3b75f5a1a044e5253 |
| IEDL.DBID | JAA |
| ISSN | 0025-7079 |
| IngestDate | Sat Oct 05 06:25:04 EDT 2024 Thu Oct 10 19:07:39 EDT 2024 Thu Nov 21 22:20:24 EST 2024 Tue Oct 15 23:45:48 EDT 2024 Sun Oct 29 17:13:37 EDT 2023 Fri Feb 02 07:04:40 EST 2024 |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 11 |
| Language | English |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c4680-95647c0b6664e6f6dfece2b5880be54245b4c60e986432cb3b75f5a1a044e5253 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
| PMID | 23047786 |
| PQID | 1112234360 |
| PQPubID | 49247 |
| PageCount | 9 |
| ParticipantIDs | proquest_miscellaneous_1095812128 proquest_journals_1112234360 crossref_primary_10_1097_MLR_0b013e31826ec185 pubmed_primary_23047786 wolterskluwer_health_00005650-201211000-00010 jstor_primary_41714606 |
| PublicationCentury | 2000 |
| PublicationDate | 20121101 2012-November 2012-Nov 2012-11-00 |
| PublicationDateYYYYMMDD | 2012-11-01 |
| PublicationDate_xml | – month: 11 year: 2012 text: 20121101 day: 1 |
| PublicationDecade | 2010 |
| PublicationPlace | United States |
| PublicationPlace_xml | – name: United States – name: Philadelphia |
| PublicationTitle | Medical care |
| PublicationTitleAlternate | Med Care |
| PublicationYear | 2012 |
| Publisher | Lippincott Williams & Wilkins Lippincott Williams & Wilkins, Inc Lippincott Williams & Wilkins Ovid Technologies |
| Publisher_xml | – name: Lippincott Williams & Wilkins – name: Lippincott Williams & Wilkins, Inc – name: Lippincott Williams & Wilkins Ovid Technologies |
| References | Wang (R12-10-20210211) 2005; 353 Bootman (R11-10-20210211) 1997; 157 Schneider (R5-10-20210211) 2005; 294 Liperoti (R19-10-20210211) 2009; 70 Gill (R15-10-20210211) 2007; 146 Brookhart (R30-10-20210211) 2006; 163 Komisar (R24-10-20210211) 2005; 42 Alexopoulos (R4-10-20210211) 2004; 65 Austin (R36-10-20210211) 2009; 5 Bagnall (R1-10-20210211) 2003; 7 Simoni-Wastila (R20-10-20210211) 2009; 17 Suh (R13-10-20210211) 2005; 17 Handler (R10-10-20210211) 2006; 4 Baser (R29-10-20210211) 2006; 9 Ray (R6-10-20210211) 2001; 58 Robins (R41-10-20210211) 1992; 48 Rochon (R18-10-20210211) 2008; 168 Schneider (R7-10-20210211) 2006; 14 Hollis (R17-10-20210211) 2007; 41 Aparasu (R31-10-20210211) 2008; 6 Schneeweiss (R16-10-20210211) 2007; 176 Bagchi (R21-10-20210211) 2007; 28 Raivio (R14-10-20210211) 2007; 15 Jeste (R2-10-20210211) 2005; 13 Carson (R3-10-20210211) 2006; 54 Jano (R28-10-20210211) 2007; 58 |
| References_xml | – volume: 146 start-page: 775 year: 2007 ident: R15-10-20210211 article-title: Antipsychotic drug use and mortality in older adults with dementia. publication-title: Ann Intern Med doi: 10.7326/0003-4819-146-11-200706050-00006 contributor: fullname: Gill – volume: 13 start-page: 340 year: 2005 ident: R2-10-20210211 article-title: Atypical antipsychotics in elderly patients with dementia or schizophrenia: review of recent literature. publication-title: Harv Rev Psychiatry doi: 10.1080/10673220500433247 contributor: fullname: Jeste – volume: 70 start-page: 1340 year: 2009 ident: R19-10-20210211 article-title: All-cause mortality associated with atypical and conventional antipsychotics among nursing home residents with dementia: a retrospective cohort study. publication-title: J Clin Psychiatry doi: 10.4088/JCP.08m04597yel contributor: fullname: Liperoti – volume: 294 start-page: 1934 year: 2005 ident: R5-10-20210211 article-title: Risk of death with atypical antipsychotic drug treatment for dementia: meta-analysis of randomized placebo-controlled trials. publication-title: JAMA doi: 10.1001/jama.294.15.1934 contributor: fullname: Schneider – volume: 176 start-page: 627 year: 2007 ident: R16-10-20210211 article-title: Risk of death associated with the use of conventional versus atypical antipsychotic drugs among elderly patients. publication-title: CMAJ doi: 10.1503/cmaj.061250 contributor: fullname: Schneeweiss – volume: 54 start-page: 354 year: 2006 ident: R3-10-20210211 article-title: A systematic review of the efficacy and safety of atypical antipsychotics in patients with psychological and behavioral symptoms of dementia. publication-title: J Am Geriatr Soc doi: 10.1111/j.1532-5415.2005.00566.x contributor: fullname: Carson – volume: 42 start-page: 171 year: 2005 ident: R24-10-20210211 article-title: Unmet long-term care needs: an analysis of Medicare-Medicaid dual eligibles. publication-title: Inquiry doi: 10.5034/inquiryjrnl_42.2.171 contributor: fullname: Komisar – volume: 58 start-page: 1161 year: 2001 ident: R6-10-20210211 article-title: Antipsychotics and the risk of sudden cardiac death. publication-title: Arch Gen Psychiatry doi: 10.1001/archpsyc.58.12.1161 contributor: fullname: Ray – volume: 157 start-page: 2089 year: 1997 ident: R11-10-20210211 article-title: The health care cost of drug-related morbidity and mortality in nursing facilities. publication-title: Arch Intern Med doi: 10.1001/archinte.1997.00440390083011 contributor: fullname: Bootman – volume: 17 start-page: 429 year: 2005 ident: R13-10-20210211 article-title: Effect of antipsychotics on mortality in elderly patients with dementia: a 1-year prospective study in a nursing home. publication-title: Int Psychogeriatr doi: 10.1017/S1041610205002243 contributor: fullname: Suh – volume: 14 start-page: 191 year: 2006 ident: R7-10-20210211 article-title: Efficacy and adverse effects of atypical antipsychotics for dementia: meta-analysis of randomized, placebo-controlled trials. publication-title: Am J Geriatr Psychiatry doi: 10.1097/01.JGP.0000200589.01396.6d contributor: fullname: Schneider – volume: 4 start-page: 264 year: 2006 ident: R10-10-20210211 article-title: Epidemiology of medication-related adverse events in nursing homes. publication-title: Am J Geriatr Pharmacother doi: 10.1016/j.amjopharm.2006.09.011 contributor: fullname: Handler – volume: 65 start-page: 5 issue: suppl 2 year: 2004 ident: R4-10-20210211 article-title: Expert consensus panel for using antipsychotic drugs in older patients. Using antipsychotic agents in older patients. publication-title: J Clin Psychiatry contributor: fullname: Alexopoulos – volume: 163 start-page: 1149 year: 2006 ident: R30-10-20210211 article-title: Variable selection for propensity score models. publication-title: Am J Epidemiol doi: 10.1093/aje/kwj149 contributor: fullname: Brookhart – volume: 7 start-page: 1 year: 2003 ident: R1-10-20210211 article-title: A systematic review of atypical antipsychotic drugs in schizophrenia. publication-title: Health Technol Assess doi: 10.3310/hta7130 contributor: fullname: Bagnall – volume: 168 start-page: 1090 year: 2008 ident: R18-10-20210211 article-title: Antipsychotic therapy and short-term serious events in older adults with dementia. publication-title: Arch Intern Med doi: 10.1001/archinte.168.10.1090 contributor: fullname: Rochon – volume: 5 start-page: 1 year: 2009 ident: R36-10-20210211 article-title: Type I error rates, coverage of confidence intervals, and variance estimation in propensity-score matched analysis. publication-title: Int J Biostat doi: 10.2202/1557-4679.1146 contributor: fullname: Austin – volume: 48 start-page: 479 year: 1992 ident: R41-10-20210211 article-title: Estimating exposure effects by modeling the expectation of exposure conditional on confounders. publication-title: Biometrics doi: 10.2307/2532304 contributor: fullname: Robins – volume: 353 start-page: 2335 year: 2005 ident: R12-10-20210211 article-title: Risk of death in elderly users of conventional vs. atypical antipsychotic medications. publication-title: N Engl J Med doi: 10.1056/NEJMoa052827 contributor: fullname: Wang – volume: 9 start-page: 377 year: 2006 ident: R29-10-20210211 article-title: Too much ado about propensity score models Comparing methods of propensity score matching. publication-title: Value Health doi: 10.1111/j.1524-4733.2006.00130.x contributor: fullname: Baser – volume: 28 start-page: 43 year: 2007 ident: R21-10-20210211 article-title: Prescription drug use and expenditures among dually eligible beneficiaries. publication-title: Health Care Financ Rev contributor: fullname: Bagchi – volume: 17 start-page: 417 year: 2009 ident: R20-10-20210211 article-title: Association of antipsychotic use with hospital events and mortality among Medicare beneficiaries residing in long-term care facilities. publication-title: Am J Geriatr Psychiatry doi: 10.1097/JGP.0b013e31819b8936 contributor: fullname: Simoni-Wastila – volume: 6 start-page: 198 year: 2008 ident: R31-10-20210211 article-title: Hospitalization risk associated with typical and atypical antipsychotic use in community-dwelling elderly patients. publication-title: Am J Geriatr Pharmacother doi: 10.1016/j.amjopharm.2008.10.003 contributor: fullname: Aparasu – volume: 15 start-page: 416 year: 2007 ident: R14-10-20210211 article-title: Neither atypical nor conventional antipsychotics increase mortality or hospital admissions among elderly patients with dementia: a two-year prospective study. publication-title: Am J Geriatr Psychiatry doi: 10.1097/JGP.0b013e31802d0b00 contributor: fullname: Raivio – volume: 41 start-page: 751 year: 2007 ident: R17-10-20210211 article-title: Risk of death associated with antipsychotic drug dispensing in residential aged care facilities. publication-title: Aust N Z J Psychiatry doi: 10.1080/00048670701519864 contributor: fullname: Hollis – volume: 58 start-page: 1400 year: 2007 ident: R28-10-20210211 article-title: Antipsychotic utilization and expenditure trends among elderly persons. publication-title: Psychiatr Serv doi: 10.1176/ps.2007.58.11.1400 contributor: fullname: Jano |
| SSID | ssj0017352 |
| Score | 2.2390757 |
| Snippet | Background: Antipsychotic use among dual-eligible nursing home residents is a concern for cost and safety considerations. Objective: To examine the comparative... BACKGROUND:Antipsychotic use among dual-eligible nursing home residents is a concern for cost and safety considerations. OBJECTIVE:To examine the comparative... Antipsychotic use among dual-eligible nursing home residents is a concern for cost and safety considerations. To examine the comparative risk of death in... Antipsychotic use among dual-eligible nursing home residents is a concern for cost and safety considerations. To examine the comparative risk of death in... BACKGROUNDAntipsychotic use among dual-eligible nursing home residents is a concern for cost and safety considerations.OBJECTIVETo examine the comparative risk... |
| SourceID | proquest crossref pubmed wolterskluwer jstor |
| SourceType | Aggregation Database Index Database Publisher |
| StartPage | 961 |
| SubjectTerms | Aged Aged, 80 and over Antipsychotic agents Antipsychotic Agents - administration & dosage Antipsychotic Agents - classification Death Dementia Female Health hazards Homes for the Aged - statistics & numerical data Humans Kaplan-Meier Estimate Male Medicaid Medicaid - statistics & numerical data Medical treatment Medicare Medicare - statistics & numerical data Mortality Nursing homes Nursing Homes - statistics & numerical data Older adults Older people Prescription drugs Proportional Hazards Models Regression analysis Retrospective Studies Risk Assessment Time Factors United States - epidemiology |
| Title | Risk of Death in Dual-eligible Nursing Home Residents Using Typical or Atypical Antipsychotic Agents |
| URI | https://www.jstor.org/stable/41714606 http://ovidsp.ovid.com/ovidweb.cgi?T=JS&NEWS=n&CSC=Y&PAGE=fulltext&D=ovft&AN=00005650-201211000-00010 https://www.ncbi.nlm.nih.gov/pubmed/23047786 https://www.proquest.com/docview/1112234360 https://search.proquest.com/docview/1095812128 |
| Volume | 50 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://sdu.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwjV1La9wwEB6aPZSUkDZp07hNgwrpUUS2JD-OS3dDD00PmxRyM5Ysw5Jgl3iX_v3OSLbzoIXeDBaS0OjxSd_MNwBnNre5SzPS2E8kVwiReWEqwS3ulyYmwW3lk9heZT9u8sWSZHK-jLEw5Fbp_QI9i48Aydy5c0VZulMS1t7BAysI5E9UQSZ1MuVlFVkxxscV2fnl99XDQ1-SOhtTyuRH509wQfwbuHwFe7874qv7W--u_ujQuXj9n919A_sDqmTzMA0O4IVrD-Hl5cCbH8JeeJ1jIejoLdSrdX_LuoYtCAGydcsW2-qOe_dkrJsNbwiMkqizlaOUnu2mZ96_gOHVlSzLuns23wzf83azHgK6sJk5xWv17-DnxfL66zc-5FvgVqW54HhVUpkVBm80yqVNWjfOusRoXOLGaaJIjbKpcKToLhNrpMl0o6u4Eko5nWh5BLO2a90xMNLoqREMyAbrkrGsTN5YU2lTFMbUjYmAj1YofwVZjXKkw9Fq5XOrRXDkh3kqPI5xBCej7cph9fV0q0HUo2QqIvg8_cZ1Q2RI1bpu21NTGsENHs8RvA82nyr3XGSWY-X8ySQoQ2wqEfaIG7XALYYU8obg_Fh8-FcvP8IuFQ0xjCcw29xv3SfY6evtqZ_MfwDq7Ool |
| link.rule.ids | 315,782,786,820,27933,27934,58033,58266,64549,64569,65344,65364 |
| linkProvider | JSTOR |
| linkToHtml | http://sdu.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwjV1Lb9QwEB5BkYCq4lFoGyhgJDhadWI7j-OKbVXEbg9LkbhFseNIq1YJanbF32fGTtKCQOIWKYltefz47G_mG4APNre5SzPS2E8kVwiReWEqwS2ulyYmwW3lk9h-zS6-5_NTksn5OMbCkFul9wv0LD4CJHPtThRl6U5JWPuBzoWUQSJ_IgsyqZMpM6vIijFCrshOlovV7VVfkjobU9LkOztQcEL8G7zchb2fHTHW_ZV3WL-z7Zw9_c8GP4MnA65kszAQnsM91-7Dw-XAnO_DXrifYyHs6AXUq3V_xbqGzQkDsnXL5tvqmnsHZSybDbcIjNKos5WjpJ7tpmfew4Dh4ZVsy7obNtsMz7N2sx5CurCaGUVs9S_h29np5adzPmRc4FalueB4WFKZFQbPNMqlTVo3zrrEaJzkxmkiSY2yqXCk6S4Ta6TJdKOruBJKOZ1oeQA7bde6I2Ck0lMjHJANliVjWZm8sabSpiiMqRsTAR-tUP4IwhrlSIij1co_rRbBge_m6eOxjyM4Hm1XDvOvp3MN4h4lUxHB--k1zhyiQ6rWddueqtIIb3CDjuAw2Hwq3LORWY6F898GQRmiU4myR-SoBS4ypJE3hOfH4tW_WvkOHp1fLhfl4vPFl9fwmH4LEY3HsLO52bo3cL-vt2_9wP4FbMrteg |
| linkToPdf | http://sdu.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwlV1Lb9QwEB6VVqpAFY9CIbSAkbhwiNaJH0mOK7YrEG2FFpC4RbHjSKtWSdXsir_PjJ2EguiBW6QktuXx47O_mW8A3tnc5k5npLGfilgiRI4LU_HY4nppEhLclj6J7dfs4ke-OCWZnPdjLAy5VXq_QM_iI0AyV252XTczSZm6NYlr7ymExDrI5E-EQSZUOmVn5VkxRskV2ez8bPX7ui_VziaUOPnWLhQcEf8FMR_Awc-OWOv-0jut39p6lo_-o9GP4eGAL9k8DIgnsOPaQ9g_Hxj0QzgI93QshB89hXq17i9Z17AFYUG2btliW13F3lEZy2fDbQKjdOps5Si5Z7vpmfc0YHiIJRuz7obNN8PzvN2sh9AurGZOkVv9M_i-PP324WM8ZF6IrdQ5j_HQJDPLDZ5tpNONrhtnXWoUTnbjFJGlRlrNHWm7i9QaYTLVqCqpuJROpUocwW7bte4FMFLrqREWiAbLEomoTN5YUylTFMbUjYkgHi1RXgeBjXIkxtFy5d-Wi-DId_X08djHEZyM9iuHedjT-QbxjxSaR_B2eo0ziGiRqnXdtqeqFMIc3KgjeB7sPhXuWcksx8LjPwZCGaJUibpHBKk4LjaklTeE6Sf85V2tfAP7XxbL8uzTxedjuE9_hcDGE9jd3GzdK7jX19vXfmz_AmQm8AA |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Risk+of+Death+in+Dual-eligible+Nursing+Home+Residents+Using+Typical+or+Atypical+Antipsychotic+Agents&rft.jtitle=Medical+care&rft.au=Aparasu%2C+Rajender+R.&rft.au=Chatterjee%2C+Satabdi&rft.au=Mehta%2C+Sandhya&rft.au=Chen%2C+Hua&rft.date=2012-11-01&rft.pub=Lippincott+Williams+%26+Wilkins&rft.issn=0025-7079&rft.eissn=1537-1948&rft.volume=50&rft.issue=11&rft.spage=961&rft.epage=969&rft_id=info:doi/10.1097%2FMLR.0b013e31826ec185&rft.externalDocID=41714606 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0025-7079&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0025-7079&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0025-7079&client=summon |