MicroRNA-200 family governs ovarian inclusion cyst formation and mode of ovarian cancer spread

Epidemiologic and histopathologic findings and the laying hen model support the long-standing incessant ovulation hypothesis and cortical inclusion cyst involvement in sporadic ovarian cancer development. MicroRNA-200 (miR-200) family is highly expressed in ovarian cancer. Herewith, we show that ova...

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Bibliographic Details
Published in:	Oncogene Vol. 39; no. 20; pp. 4045 - 4060
Main Authors:	Choi, Pui-Wah, So, Wai Wing, Yang, Junzheng, Liu, Shubai, Tong, Ka Kui, Kwan, Kin Ming, Kwok, Jamie S.-L., Tsui, Stephen K. W., Ng, Shu-Kay, Hales, Karen H., Hales, Dale B., Welch, William R., Crum, Christopher P., Fong, Wing-Ping, Berkowitz, Ross S., Ng, Shu-Wing
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 14-05-2020 Nature Publishing Group
Subjects:	14/19 14/32 38 42/109 42/89 631/67 631/67/1517 82/51 82/80 96/106 96/95 Apoptosis Biotechnology industry Bone morphogenetic proteins Cancer Carcinogenesis Carcinogenesis - genetics Carcinogenesis - metabolism Carcinogenesis - pathology Cell activation Cell Biology Cell culture Cysts Development and progression E-cadherin Epidemiology Estrogen Estrogens Female Gene expression Gene Expression Regulation, Neoplastic Genes Human Genetics Humans Hypoxia Internal Medicine Medicine Medicine & Public Health Mesenchyme MicroRNA MicroRNAs MicroRNAs - biosynthesis MicroRNAs - genetics miRNA Myosin Oncology Oncology, Experimental Ovarian cancer Ovarian Cysts - genetics Ovarian Cysts - metabolism Ovarian Cysts - pathology Ovarian Neoplasms - genetics Ovarian Neoplasms - metabolism Ovarian Neoplasms - pathology Ovulation Phosphorylation RNA, Neoplasm - biosynthesis RNA, Neoplasm - genetics Scientific equipment and supplies industry Stem cells Transforming growth factors California United States Massachusetts China
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