Ultrastructural and immunohistochemical study of epithelioid hemangioendothelioma of bone: coexpression of epithelial and endothelial markers

Four cases of epithelioid hemangioendothelioma of bone--a borderline malignant tumor of vascular origin--were studied ultrastructurally and immunohistochemically. The epithelioid tumor cells were positive for vimentin, polyclonal and monoclonal cytokeratins, and the endothelial markers factor VIII-r...

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Bibliographic Details
Published in:	Ultrastructural pathology Vol. 14; no. 2; p. 141
Main Authors:	van Haelst, U J, Pruszczynski, M, ten Cate, L N, Mravunac, M
Format:	Journal Article
Language:	English
Published:	England 01-03-1990
Subjects:	Adult Aged Biomarkers, Tumor - analysis Bone Neoplasms - analysis Bone Neoplasms - ultrastructure Cell Nucleus - ultrastructure Cytoplasm - ultrastructure Endothelium - analysis Epithelium - analysis Female Humans Immunohistochemistry Keratins - analysis Lectins - analysis Male Microscopy, Electron Middle Aged Plant Lectins Sarcoma, Ewing - ultrastructure Vimentin - analysis von Willebrand Factor - analysis
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Summary:	Four cases of epithelioid hemangioendothelioma of bone--a borderline malignant tumor of vascular origin--were studied ultrastructurally and immunohistochemically. The epithelioid tumor cells were positive for vimentin, polyclonal and monoclonal cytokeratins, and the endothelial markers factor VIII-related antigen (FVIII:RAg) and Ulex europaeus agglutinin I. The coexpression of polyclonal cytokeratin and FVIII:RAg was demonstrated by means of step sections in the same tumor cells. The endothelial origin of epithelioid tumor cells was supported ultrastructurally by identification of Weibel-Palade bodies.
ISSN:	0191-3123
DOI:	10.1080/01913129009025126