The effects of age, sex, and handling on behavioral parameters in the multivariate concentric square field™ test
•Handling increases risk taking and reduces shelter seeking.•Females are more exploratory than males.•No age differences in risk taking or risk assessment.•Behavioral components assayed by the MCSF differ between adolescents and adults.•Center circle and bridge variables do not reflect the same dime...
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| Published in: | Physiology & behavior Vol. 229; p. 113243 |
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| Abstract | •Handling increases risk taking and reduces shelter seeking.•Females are more exploratory than males.•No age differences in risk taking or risk assessment.•Behavioral components assayed by the MCSF differ between adolescents and adults.•Center circle and bridge variables do not reflect the same dimension of risk taking.
The multivariate concentric square field™ (MCSF) is a complex and ethologically relevant apparatus that is designed to measure several behavioral parameters within the same test session including risk-taking, risk-assessment, shelter-seeking (anxiety relieving), exploration, and general activity. While several studies have behaviorally and pharmacologically validated the use of the MCSF in adults, far fewer have used adolescents. Given the well-established link between adolescence and risk-taking, it is important to validate use of the MCSF in adolescence. The present study compared the effects of age, sex, and handling on behavioral categories in the MCSF. In addition, principal component analyses were used to compare the underlying behavioral components in adolescent and adult Sprague-Dawley rats. Results revealed that handling increased risk-taking and reduced shelter-seeking. Females were more exploratory than males, but no compelling age differences in risk-taking or risk-assessment were found. Principal component analyses revealed six major principal components for both adolescents and adults with the first and second components consisting mainly of center/center circle, risk-assessment, and shelter-seeking variables in adolescence, and general activity and center/center circle variables in adults. These results confirm age differences in the underlying behavioral components in the MCSF. |
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| AbstractList | •Handling increases risk taking and reduces shelter seeking.•Females are more exploratory than males.•No age differences in risk taking or risk assessment.•Behavioral components assayed by the MCSF differ between adolescents and adults.•Center circle and bridge variables do not reflect the same dimension of risk taking.
The multivariate concentric square field™ (MCSF) is a complex and ethologically relevant apparatus that is designed to measure several behavioral parameters within the same test session including risk-taking, risk-assessment, shelter-seeking (anxiety relieving), exploration, and general activity. While several studies have behaviorally and pharmacologically validated the use of the MCSF in adults, far fewer have used adolescents. Given the well-established link between adolescence and risk-taking, it is important to validate use of the MCSF in adolescence. The present study compared the effects of age, sex, and handling on behavioral categories in the MCSF. In addition, principal component analyses were used to compare the underlying behavioral components in adolescent and adult Sprague-Dawley rats. Results revealed that handling increased risk-taking and reduced shelter-seeking. Females were more exploratory than males, but no compelling age differences in risk-taking or risk-assessment were found. Principal component analyses revealed six major principal components for both adolescents and adults with the first and second components consisting mainly of center/center circle, risk-assessment, and shelter-seeking variables in adolescence, and general activity and center/center circle variables in adults. These results confirm age differences in the underlying behavioral components in the MCSF. The multivariate concentric square field™ (MCSF) is a complex and ethologically relevant apparatus that is designed to measure several behavioral parameters within the same test session including risk-taking, risk-assessment, shelter-seeking (anxiety relieving), exploration, and general activity. While several studies have behaviorally and pharmacologically validated the use of the MCSF in adults, far fewer have used adolescents. Given the well-established link between adolescence and risk-taking, it is important to validate use of the MCSF in adolescence. The present study compared the effects of age, sex, and handling on behavioral categories in the MCSF. In addition, principal component analyses were used to compare the underlying behavioral components in adolescent and adult Sprague-Dawley rats. Results revealed that handling increased risk-taking and reduced shelter-seeking. Females were more exploratory than males, but no compelling age differences in risk-taking or risk-assessment were found. Principal component analyses revealed six major principal components for both adolescents and adults with the first and second components consisting mainly of center/center circle, risk-assessment, and shelter-seeking variables in adolescence, and general activity and center/center circle variables in adults. These results confirm age differences in the underlying behavioral components in the MCSF. |
| ArticleNumber | 113243 |
| Author | Gore-Langton, Jonathan Kent Spear, Linda Patia Werner, David Francis |
| Author_xml | – sequence: 1 givenname: Jonathan Kent surname: Gore-Langton fullname: Gore-Langton, Jonathan Kent email: jgorela1@binghamton.edu – sequence: 2 givenname: David Francis surname: Werner fullname: Werner, David Francis email: dwerner@binghamton.edu – sequence: 3 givenname: Linda Patia surname: Spear fullname: Spear, Linda Patia email: lspear@binghamton.edu |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/33159929$$D View this record in MEDLINE/PubMed |
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| CitedBy_id | crossref_primary_10_3389_fnbeh_2021_691578 crossref_primary_10_1016_j_nlm_2023_107831 crossref_primary_10_1002_ece3_8771 crossref_primary_10_3389_fnins_2021_811401 crossref_primary_10_3389_fnbeh_2021_637074 crossref_primary_10_1016_j_bbr_2022_114184 |
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| Keywords | Adults Shelter-seeking Multivariate concentric square field Adolescents Risk-taking Handling |
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| Snippet | •Handling increases risk taking and reduces shelter seeking.•Females are more exploratory than males.•No age differences in risk taking or risk... The multivariate concentric square field™ (MCSF) is a complex and ethologically relevant apparatus that is designed to measure several behavioral parameters... |
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| SubjectTerms | Adolescents Adults Alcohol Drinking Animals Behavior, Animal Exploratory Behavior Handling Multivariate concentric square field Rats Rats, Sprague-Dawley Risk-Taking Shelter-seeking |
| Title | The effects of age, sex, and handling on behavioral parameters in the multivariate concentric square field™ test |
| URI | https://dx.doi.org/10.1016/j.physbeh.2020.113243 https://www.ncbi.nlm.nih.gov/pubmed/33159929 https://search.proquest.com/docview/2458735933 https://pubmed.ncbi.nlm.nih.gov/PMC8793682 |
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