Astrocyte-derived extracellular vesicles: Neuroreparative properties and role in the pathogenesis of neurodegenerative disorders

Astrocyte-derived extracellular vesicles: Neuroreparative properties and role in the pathogenesis of neurodegenerative disorders

Extracellular vesicles (EVs) released by neural cells play an essential role in brain homeostasis and the crosstalk between neural cells and the periphery. EVs are diverse, nano-sized vesicles, which transport proteins, nucleic acids, and lipids between cells over short and long expanses and hence a...

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Published in:Journal of controlled release Vol. 323; pp. 225 - 239
Main Authors: Upadhya, Raghavendra, Zingg, Winston, Shetty, Siddhant, Shetty, Ashok K.
Format: Journal Article
Language:English
Published: Netherlands Elsevier B.V 10-07-2020
Subjects:
Alzheimer's disease
Amyotrophic lateral sclerosis
Astrocyte-derived extracellular vesicles
Astrocytes
Exosomes
Microvesicles
Neuroinflammation
Neurological disorders
Parkinson's disease
Stroke
Parkinson's disease
BBB
ALIX
TAR
CD81
NCAM
JNK
ALS
HMGB1
Exosomes
STI1
EAAT-1/2
Aβ
DRPs
NF-κB
KCl
BACE-1
HIV-1 Tat
TCC-C5b-9
P13k
PTGDS
Alzheimer's disease
nSMase2
Neurological disorders
EXs
AD
ApoE ɛ4
ESCRT
RAN-T
Astrocytes
MV
PKC
Microvesicles
PDGF-B
IL-1β
IL-6
sAPPβ
lincRNAs
FGFRs
MAP
CHMP4
ERK
HIV-1
CD63
miRNAs
SEMA3A
CNS
LPS
C3
SD
TLR2/4
CSF
GWI
ApoE
ApoD
TDP43
Stroke
ILVs
EVs
FUS
NTRK3
TSG-101
VEGF
Amyotrophic lateral sclerosis
Neuroinflammation
ADEVs
Astrocyte-derived extracellular vesicles
PARP-α
ECM
Nef
PrP
SOD1
FGF-2
PD
TNF-α
Bcl2
CD9
ISEV
HD
ATP
MVBs
TLRs
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Abstract Extracellular vesicles (EVs) released by neural cells play an essential role in brain homeostasis and the crosstalk between neural cells and the periphery. EVs are diverse, nano-sized vesicles, which transport proteins, nucleic acids, and lipids between cells over short and long expanses and hence are proficient for modulating the target cells. EVs released from neural cells are implicated in synaptic plasticity, neuron-glia interface, neuroprotection, neuroregeneration, and the dissemination of neuropathological molecules. This review confers the various properties of EVs secreted by astrocytes and their potential role in health and disease with a focus on evolving concepts. Naïve astrocytes shed EVs containing a host of neuroprotective compounds, which include fibroblast growth factor-2, vascular endothelial growth factor, and apolipoprotein-D. Stimulated astrocytes secrete EVs with neuroprotective molecules including heat shock proteins, synapsin 1, unique microRNAs, and glutamate transporters. Well-characterized astrocyte-derived EVs (ADEVs) generated in specific culture conditions and ADEVs that are engineered to carry the desired miRNAs or proteins are likely useful for treating brain injury and neurogenerative diseases. On the other hand, in conditions such as Alzheimer's disease (AD), stroke, Parkinson's disease, Amyotrophic lateral sclerosis (ALS), and other neuroinflammatory conditions, EVs released by activated astrocytes appear to mediate or exacerbate the pathological processes. The examples include ADEVs spreading the dysregulated complement system in AD, mediating motoneuron toxicity in ALS, and stimulating peripheral leukocyte migration into the brain in inflammatory conditions. Strategies restraining the release of EVs by activated astrocytes or modulating the composition of ADEVs are likely beneficial for treating neurodegenerative diseases. Also, periodic analyses of ADEVs in the blood is useful for detecting astrocyte-specific biomarkers in different neurological conditions and for monitoring disease progression and remission with distinct therapeutic approaches. [Display omitted]
AbstractList Extracellular vesicles (EVs) released by neural cells play an essential role in brain homeostasis and the crosstalk between neural cells and the periphery. EVs are diverse, nano-sized vesicles, which transport proteins, nucleic acids, and lipids between cells over short and long expanses and hence are proficient for modulating the target cells. EVs released from neural cells are implicated in synaptic plasticity, neuron-glia interface, neuroprotection, neuroregeneration, and the dissemination of neuropathological molecules. This review confers the various properties of EVs secreted by astrocytes and their potential role in health and disease with a focus on evolving concepts. Naïve astrocytes shed EVs containing a host of neuroprotective compounds, which include fibroblast growth factor-2, vascular endothelial growth factor, and apolipoprotein-D. Stimulated astrocytes secrete EVs with neuroprotective molecules including heat shock proteins, synapsin 1, unique microRNAs, and glutamate transporters. Well-characterized astrocyte-derived EVs (ADEVs) generated in specific culture conditions and ADEVs that are engineered to carry the desired miRNAs or proteins are likely useful for treating brain injury and neurogenerative diseases. On the other hand, in conditions such as Alzheimer's disease (AD), stroke, Parkinson's disease, Amyotrophic lateral sclerosis (ALS), and other neuroinflammatory conditions, EVs released by activated astrocytes appear to mediate or exacerbate the pathological processes. The examples include ADEVs spreading the dysregulated complement system in AD, mediating motoneuron toxicity in ALS, and stimulating peripheral leukocyte migration into the brain in inflammatory conditions. Strategies restraining the release of EVs by activated astrocytes or modulating the composition of ADEVs are likely beneficial for treating neurodegenerative diseases. Also, periodic analyses of ADEVs in the blood is useful for detecting astrocyte-specific biomarkers in different neurological conditions and for monitoring disease progression and remission with distinct therapeutic approaches.
Extracellular vesicles (EVs) released by neural cells play an essential role in brain homeostasis and the crosstalk between neural cells and the periphery. EVs are diverse, nano-sized vesicles, which transport proteins, nucleic acids, and lipids between cells over short and long expanses and hence are proficient for modulating the target cells. EVs released from neural cells are implicated in synaptic plasticity, neuron-glia interface, neuroprotection, neuroregeneration, and the dissemination of neuropathological molecules. This review confers the various properties of EVs secreted by astrocytes and their potential role in health and disease with a focus on evolving concepts. Naïve astrocytes shed EVs containing a host of neuroprotective compounds, which include fibroblast growth factor-2, vascular endothelial growth factor, and apolipoprotein-D. Stimulated astrocytes secrete EVs with neuroprotective molecules including heat shock proteins, synapsin 1, unique microRNAs, and glutamate transporters. Well-characterized astrocyte-derived EVs (ADEVs) generated in specific culture conditions and ADEVs that are engineered to carry the desired miRNAs or proteins are likely useful for treating brain injury and neurogenerative diseases. On the other hand, in conditions such as Alzheimer's disease (AD), stroke, Parkinson's disease, Amyotrophic lateral sclerosis (ALS), and other neuroinflammatory conditions, EVs released by activated astrocytes appear to mediate or exacerbate the pathological processes. The examples include ADEVs spreading the dysregulated complement system in AD, mediating motoneuron toxicity in ALS, and stimulating peripheral leukocyte migration into the brain in inflammatory conditions. Strategies restraining the release of EVs by activated astrocytes or modulating the composition of ADEVs are likely beneficial for treating neurodegenerative diseases. Also, periodic analyses of ADEVs in the blood is useful for detecting astrocyte-specific biomarkers in different neurological conditions and for monitoring disease progression and remission with distinct therapeutic approaches. [Display omitted]
Author Upadhya, Raghavendra
Zingg, Winston
Shetty, Siddhant
Shetty, Ashok K.
Author_xml – sequence: 1
  givenname: Raghavendra
  surname: Upadhya
  fullname: Upadhya, Raghavendra
– sequence: 2
  givenname: Winston
  surname: Zingg
  fullname: Zingg, Winston
– sequence: 3
  givenname: Siddhant
  surname: Shetty
  fullname: Shetty, Siddhant
– sequence: 4
  givenname: Ashok K.
  orcidid: 0000-0001-5049-6671
  surname: Shetty
  fullname: Shetty, Ashok K.
  email: akskrs@tamu.edu
BackLink https://www.ncbi.nlm.nih.gov/pubmed/32289328$$D View this record in MEDLINE/PubMed
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ID FETCH-LOGICAL-c467t-ca0f0d4c431a770adbe846ff53f59247acc6a7f08de92e1a07d8d0a628de84803
ISSN 0168-3659
IngestDate Tue Sep 17 21:24:24 EDT 2024
Sat Oct 05 05:28:47 EDT 2024
Thu Sep 26 20:46:29 EDT 2024
Sat Sep 28 08:26:20 EDT 2024
Fri Feb 23 02:48:05 EST 2024
IsDoiOpenAccess false
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Keywords Parkinson's disease
BBB
ALIX
TAR
CD81
NCAM
JNK
ALS
HMGB1
Exosomes
STI1
EAAT-1/2
Aβ
DRPs
NF-κB
KCl
BACE-1
HIV-1 Tat
TCC-C5b-9
P13k
PTGDS
Alzheimer's disease
nSMase2
Neurological disorders
EXs
AD
ApoE ɛ4
ESCRT
RAN-T
Astrocytes
MV
PKC
Microvesicles
PDGF-B
IL-1β
IL-6
sAPPβ
lincRNAs
FGFRs
MAP
CHMP4
ERK
HIV-1
CD63
miRNAs
SEMA3A
CNS
LPS
C3
SD
TLR2/4
CSF
GWI
ApoE
ApoD
TDP43
Stroke
ILVs
EVs
FUS
NTRK3
TSG-101
VEGF
Amyotrophic lateral sclerosis
Neuroinflammation
ADEVs
Astrocyte-derived extracellular vesicles
PARP-α
ECM
Nef
PrP
SOD1
FGF-2
PD
TNF-α
Bcl2
CD9
ISEV
HD
ATP
MVBs
TLRs
Language English
License Published by Elsevier B.V.
LinkModel OpenURL
MergedId FETCHMERGED-LOGICAL-c467t-ca0f0d4c431a770adbe846ff53f59247acc6a7f08de92e1a07d8d0a628de84803
Notes ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-2
RU: Literature search, discussion of findings in original research articles, and preparation of the first draft of manuscript with figures; WZ and SS: Literature search, discussion of findings in original research articles, feedback to the manuscript, and preparation of reference list and figures; AKS: Literature search, discussion of findings in original research articles, manuscript writing, editing, and preparation of the final version of the manuscript.
Author contributions
ORCID 0000-0001-5049-6671
OpenAccessLink http://manuscript.elsevier.com/S0168365920302303/pdf/S0168365920302303.pdf
PMID 32289328
PQID 2390171723
PQPubID 23479
PageCount 15
ParticipantIDs pubmedcentral_primary_oai_pubmedcentral_nih_gov_7299747
proquest_miscellaneous_2390171723
crossref_primary_10_1016_j_jconrel_2020_04_017
pubmed_primary_32289328
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PublicationDate 2020-07-10
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PublicationDate_xml – month: 07
  year: 2020
  text: 2020-07-10
  day: 10
PublicationDecade 2020
PublicationPlace Netherlands
PublicationPlace_xml – name: Netherlands
PublicationTitle Journal of controlled release
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Publisher Elsevier B.V
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Snippet Extracellular vesicles (EVs) released by neural cells play an essential role in brain homeostasis and the crosstalk between neural cells and the periphery. EVs...
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SubjectTerms Alzheimer's disease
Amyotrophic lateral sclerosis
Astrocyte-derived extracellular vesicles
Astrocytes
Exosomes
Microvesicles
Neuroinflammation
Neurological disorders
Parkinson's disease
Stroke
Title Astrocyte-derived extracellular vesicles: Neuroreparative properties and role in the pathogenesis of neurodegenerative disorders
URI https://dx.doi.org/10.1016/j.jconrel.2020.04.017
https://www.ncbi.nlm.nih.gov/pubmed/32289328
https://search.proquest.com/docview/2390171723
https://pubmed.ncbi.nlm.nih.gov/PMC7299747
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