seven-up Controls Switching of Transcription Factors that Specify Temporal Identities of Drosophila Neuroblasts
Drosophila neuronal stem cell neuroblasts (NB) constantly change character upon division, to produce a different type of progeny at the next division. Transcription factors Hunchback (HB), Krüppel (KR), Pdm (PDM), etc. are expressed sequentially in each NB and act as determinants of birth-order iden...
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| Published in: | Developmental cell Vol. 8; no. 2; pp. 203 - 213 |
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| Format: | Journal Article |
| Language: | English |
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| Abstract | Drosophila neuronal stem cell neuroblasts (NB) constantly change character upon division, to produce a different type of progeny at the next division. Transcription factors Hunchback (HB), Krüppel (KR), Pdm (PDM), etc. are expressed sequentially in each NB and act as determinants of birth-order identity. How a NB switches its expression profile from one transcription factor to the next is poorly understood. We show that the HB-to-KR switch is directed by the nuclear receptor Seven-up (SVP). SVP expression is confined to a temporally restricted subsection within the NB’s lineage. Loss of SVP function causes an increase in the number of HB-positive cells within several NB lineages, whereas misexpression of
svp leads to the loss of these early-born neurons. Lineage analysis provides evidence that
svp is required to switch off HB at the proper time. Thus,
svp modifies the self-renewal stem cell program to allow chronological change of cell fates, thereby generating neuronal diversity. |
|---|---|
| AbstractList | Drosophila neuronal stem cell neuroblasts (NB) constantly change character upon division, to produce a different type of progeny at the next division. Transcription factors Hunchback (HB), Krüppel (KR), Pdm (PDM), etc. are expressed sequentially in each NB and act as determinants of birth-order identity. How a NB switches its expression profile from one transcription factor to the next is poorly understood. We show that the HB-to-KR switch is directed by the nuclear receptor Seven-up (SVP). SVP expression is confined to a temporally restricted subsection within the NB's lineage. Loss of SVP function causes an increase in the number of HB-positive cells within several NB lineages, whereas misexpression of svp leads to the loss of these early-born neurons. Lineage analysis provides evidence that svp is required to switch off HB at the proper time. Thus, svp modifies the self-renewal stem cell program to allow chronological change of cell fates, thereby generating neuronal diversity. Drosophila neuronal stem cell neuroblasts (NB) constantly change character upon division, to produce a different type of progeny at the next division. Transcription factors Hunchback (HB), Kruppel (KR), Pdm (PDM), etc. are expressed sequentially in each NB and act as determinants of birth-order identity. How a NB switches its expression profile from one transcription factor to the next is poorly understood. We show that the HB-to-KR switch is directed by the nuclear receptor Seven-up (SVP). SVP expression is confined to a temporally restricted subsection within the NB's lineage. Loss of SVP function causes an increase in the number of HB-positive cells within several NB lineages, whereas misexpression of svp leads to the loss of these early-born neurons. Lineage analysis provides evidence that svp is required to switch off HB at the proper time. Thus, svp modifies the self-renewal stem cell program to allow chronological change of cell fates, thereby generating neuronal diversity. Drosophila neuronal stem cell neuroblasts (NB) constantly change character upon division, to produce a different type of progeny at the next division. Transcription factors Hunchback (HB), Krüppel (KR), Pdm (PDM), etc. are expressed sequentially in each NB and act as determinants of birth-order identity. How a NB switches its expression profile from one transcription factor to the next is poorly understood. We show that the HB-to-KR switch is directed by the nuclear receptor Seven-up (SVP). SVP expression is confined to a temporally restricted subsection within the NB’s lineage. Loss of SVP function causes an increase in the number of HB-positive cells within several NB lineages, whereas misexpression of svp leads to the loss of these early-born neurons. Lineage analysis provides evidence that svp is required to switch off HB at the proper time. Thus, svp modifies the self-renewal stem cell program to allow chronological change of cell fates, thereby generating neuronal diversity. |
| Author | Okabe, Masataka Hiromi, Yasushi Kanai, Makoto I. |
| Author_xml | – sequence: 1 givenname: Makoto I. surname: Kanai fullname: Kanai, Makoto I. organization: Division of Developmental Genetics, National Institute of Genetics, 1111 Yata, Mishima, Shizuoka 411-8540, Japan – sequence: 2 givenname: Masataka surname: Okabe fullname: Okabe, Masataka organization: Division of Developmental Genetics, National Institute of Genetics, 1111 Yata, Mishima, Shizuoka 411-8540, Japan – sequence: 3 givenname: Yasushi surname: Hiromi fullname: Hiromi, Yasushi email: yhiromi@lab.nig.ac.jp organization: Division of Developmental Genetics, National Institute of Genetics, 1111 Yata, Mishima, Shizuoka 411-8540, Japan |
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| Keywords | Regulation(control) Arthropoda Insecta Development Invertebrata Transcription factor Neuroblast Drosophila melanogaster Diptera Switching Drosophilidae |
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| SubjectTerms | Animals Animals, Genetically Modified Biological and medical sciences Cell Differentiation Cell differentiation, maturation, development, hematopoiesis Cell Division Cell physiology Central Nervous System - cytology Central Nervous System - embryology DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism Drosophila Drosophila - cytology Drosophila - genetics Drosophila - growth & development Drosophila - metabolism Drosophila Proteins - genetics Drosophila Proteins - metabolism Fundamental and applied biological sciences. Psychology Gene Expression Regulation, Developmental Genes, Insect Kruppel-Like Transcription Factors Molecular and cellular biology Multipotent Stem Cells - cytology Mutation Neurons - cytology Receptors, Steroid - genetics Receptors, Steroid - metabolism Repressor Proteins - genetics Repressor Proteins - metabolism Transcription Factors - genetics Transcription Factors - metabolism |
| Title | seven-up Controls Switching of Transcription Factors that Specify Temporal Identities of Drosophila Neuroblasts |
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