Heart rate variability in infants with West syndrome
Highlights • During hypsarrhythmia the WS-patients had significantly lower heart rate variability. • At the final examination the patients no longer differed from the controls. • No prognostic factors concerning neither aetiology nor clinical outcome were found.
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| Published in: | Seizure (London, England) Vol. 27; pp. 10 - 15 |
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| Abstract | Highlights • During hypsarrhythmia the WS-patients had significantly lower heart rate variability. • At the final examination the patients no longer differed from the controls. • No prognostic factors concerning neither aetiology nor clinical outcome were found. |
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| AbstractList | PURPOSEWest syndrome (WS) is a severe age-related acute epileptic encephalopathy of infancy characterized by infantile spasms, hypsarrhythmia and psychomotor delay. The aim of this study was to investigate if patients with WS had an altered autonomic output to the heart.METHODSIn 23 patients with WS the heart rate variability (HRV) was investigated by examining time- and frequency-domain parameters of HRV at the time of the diagnosis of hypsarrhythmia and compared to 22 age-matched controls. For the WS patients the same dataset was obtained and compared again at the end of the study period, when hypsarrhythmia was no longer present.RESULTSCompared to controls, patients with WS during hypsarrhythmia had significantly lower SDNN (the standard deviation of the NN interval, i.e. the square root of variance) (19.2 ms; p = 0.007, Mann-Whitney's U-Test) and total power (242 ms(2); p = 0.044, Mann-Whitney's U-Test) in the awake state, indicating an abnormal autonomic output to the heart. Comparing the initial to the final examination demonstrated a significant increase in the HRV parameters SDNN (31.3 ms) and total power (757 ms(2); p = 0.001 and p = 0.013, Wilcoxon Signed Ranked Test). In addition, at the final examination the WS-patients no longer differed significantly from the controls.CONCLUSIONOur data suggest that the initial reduction in HRV in patients at the time of onset of WS is transient and related to the presence of hypsarrhythmia. Highlights • During hypsarrhythmia the WS-patients had significantly lower heart rate variability. • At the final examination the patients no longer differed from the controls. • No prognostic factors concerning neither aetiology nor clinical outcome were found. West syndrome (WS) is a severe age-related acute epileptic encephalopathy of infancy characterized by infantile spasms, hypsarrhythmia and psychomotor delay. The aim of this study was to investigate if patients with WS had an altered autonomic output to the heart. In 23 patients with WS the heart rate variability (HRV) was investigated by examining time- and frequency-domain parameters of HRV at the time of the diagnosis of hypsarrhythmia and compared to 22 age-matched controls. For the WS patients the same dataset was obtained and compared again at the end of the study period, when hypsarrhythmia was no longer present. Compared to controls, patients with WS during hypsarrhythmia had significantly lower SDNN (the standard deviation of the NN interval, i.e. the square root of variance) (19.2 ms; p = 0.007, Mann-Whitney's U-Test) and total power (242 ms(2); p = 0.044, Mann-Whitney's U-Test) in the awake state, indicating an abnormal autonomic output to the heart. Comparing the initial to the final examination demonstrated a significant increase in the HRV parameters SDNN (31.3 ms) and total power (757 ms(2); p = 0.001 and p = 0.013, Wilcoxon Signed Ranked Test). In addition, at the final examination the WS-patients no longer differed significantly from the controls. Our data suggest that the initial reduction in HRV in patients at the time of onset of WS is transient and related to the presence of hypsarrhythmia. •During hypsarrhythmia the WS-patients had significantly lower heart rate variability.•At the final examination the patients no longer differed from the controls.•No prognostic factors concerning neither aetiology nor clinical outcome were found. West syndrome (WS) is a severe age-related acute epileptic encephalopathy of infancy characterized by infantile spasms, hypsarrhythmia and psychomotor delay. The aim of this study was to investigate if patients with WS had an altered autonomic output to the heart. In 23 patients with WS the heart rate variability (HRV) was investigated by examining time- and frequency-domain parameters of HRV at the time of the diagnosis of hypsarrhythmia and compared to 22 age-matched controls. For the WS patients the same dataset was obtained and compared again at the end of the study period, when hypsarrhythmia was no longer present. Compared to controls, patients with WS during hypsarrhythmia had significantly lower SDNN (the standard deviation of the NN interval, i.e. the square root of variance) (19.2ms; p=0.007, Mann–Whitney's U-Test) and total power (242ms2; p=0.044, Mann–Whitney's U-Test) in the awake state, indicating an abnormal autonomic output to the heart. Comparing the initial to the final examination demonstrated a significant increase in the HRV parameters SDNN (31.3ms) and total power (757ms2; p=0.001 and p=0.013, Wilcoxon Signed Ranked Test). In addition, at the final examination the WS-patients no longer differed significantly from the controls. Our data suggest that the initial reduction in HRV in patients at the time of onset of WS is transient and related to the presence of hypsarrhythmia. |
| Author | Uldall, Peter Ballegaard, Martin Møller, Michelle Mai Høgenhaven, Hans |
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| CitedBy_id | crossref_primary_10_3389_fneur_2021_642645 crossref_primary_10_1016_j_clinph_2018_10_001 crossref_primary_10_1016_j_yebeh_2022_108635 crossref_primary_10_3389_fneur_2022_1090155 crossref_primary_10_1109_ACCESS_2024_3393984 crossref_primary_10_1111_epi_14438 crossref_primary_10_1111_epi_14587 |
| Cites_doi | 10.1590/S1807-59322011001300008 10.1016/j.seizure.2014.01.025 10.1097/WNP.0b013e318182ed2d 10.1111/j.1469-8749.2005.tb01033.x 10.1046/j.1365-2869.2002.00283.x 10.1016/j.eplepsyres.2007.12.020 10.1111/j.1528-1167.2011.03361.x 10.1016/S1474-4422(13)70214-X 10.1093/oxfordjournals.eurheartj.a014868 10.1016/j.seizure.2007.09.002 10.1111/j.1600-0404.2006.00792.x 10.1016/S0920-1211(97)00094-6 10.1007/s002469900178 10.1007/s003810100505 10.1016/j.eplepsyres.2005.02.001 10.1111/j.1535-7597.2004.42001.x 10.1111/j.1469-8749.2011.04103.x 10.1111/j.1528-1167.2010.02657.x 10.1016/S0167-5273(01)00537-X 10.1620/tjem.211.133 |
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| Keywords | Autonomic function West syndrome Infantile spasms Heart rate variability Hypsarrhythmia |
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| References | Kolsal, Serdaroglu, Cilsal, Kula, Soysal, Kurt (bib0175) 2014 Evrengul, Tanriverdi, Dursunoglu, Kaftan, Kuru, Unlu (bib0110) 2005; 63 Hallioglu, Okuyaz, Mert, Makharoblidze (bib0145) 2008; 79 Yang, Wong, Chang, Kwan, Kuo, Lee (bib0155) 2001; 17 Massin, von Bernuth (bib0190) 1997; 18 Ryvlin, Nashef, Lhatoo, Bateman, Bird, Bleasel (bib0160) 2013; 12 Pellock, Hrachovy, Shinnar, Baram, Bettis, Dlugos (bib0105) 2010; 51 Tomson, Ericson, Ihrman, Lindblad (bib0180) 1998; 30 Silvetti, Drago, Ragonese (bib0195) 2001; 81 Hattori, Hayano, Fujimoto, Ando, Mizuno, Kamei (bib0165) 2007; 211 O’Regan, Brown (bib0120) 2005; 47 Ferri, Curzi-Dascalova, Arzimanoglou, Bourgeois, Beaud, Nunes (bib0115) 2002; 11 (bib0170) 1996; 17 Devinsky (bib0125) 2004; 4 Harnod, Yang, Hsin, Shieh, Wang, Kuo (bib0140) 2008; 17 El-Sayed, Kotby, Tomoum, El-Hadidi, El Behery, El-Ganzory (bib0185) 2007; 115 Lotufo, Valiengo, Bensenor, Brunoni (bib0130) 2012; 53 Scorza, Cysneiros, de Albuquerque, Scattolini, Arida (bib0135) 2011; 66 Jansen, Vandeput, Milosevic, Ceulemans, Van Huffel, Brown (bib0150) 2011; 53 Assaf, Weller, Deutsh-Castel, Cohen, Tirosh (bib0200) 2008; 25 Harnod (10.1016/j.seizure.2015.02.003_bib0140) 2008; 17 Assaf (10.1016/j.seizure.2015.02.003_bib0200) 2008; 25 Jansen (10.1016/j.seizure.2015.02.003_bib0150) 2011; 53 Silvetti (10.1016/j.seizure.2015.02.003_bib0195) 2001; 81 Tomson (10.1016/j.seizure.2015.02.003_bib0180) 1998; 30 Yang (10.1016/j.seizure.2015.02.003_bib0155) 2001; 17 Pellock (10.1016/j.seizure.2015.02.003_bib0105) 2010; 51 Evrengul (10.1016/j.seizure.2015.02.003_bib0110) 2005; 63 Lotufo (10.1016/j.seizure.2015.02.003_bib0130) 2012; 53 Kolsal (10.1016/j.seizure.2015.02.003_bib0175) 2014 Hattori (10.1016/j.seizure.2015.02.003_bib0165) 2007; 211 Ryvlin (10.1016/j.seizure.2015.02.003_bib0160) 2013; 12 Ferri (10.1016/j.seizure.2015.02.003_bib0115) 2002; 11 Hallioglu (10.1016/j.seizure.2015.02.003_bib0145) 2008; 79 El-Sayed (10.1016/j.seizure.2015.02.003_bib0185) 2007; 115 Devinsky (10.1016/j.seizure.2015.02.003_bib0125) 2004; 4 O’Regan (10.1016/j.seizure.2015.02.003_bib0120) 2005; 47 Massin (10.1016/j.seizure.2015.02.003_bib0190) 1997; 18 Scorza (10.1016/j.seizure.2015.02.003_bib0135) 2011; 66 (10.1016/j.seizure.2015.02.003_bib0170) 1996; 17 |
| References_xml | – volume: 30 start-page: 77 year: 1998 end-page: 83 ident: bib0180 article-title: Heart rate variability in patients with epilepsy publication-title: Epilepsy Res contributor: fullname: Lindblad – volume: 17 start-page: 354 year: 1996 end-page: 381 ident: bib0170 article-title: Heart rate variability. Standards of measurement, physiological interpretation, and clinical, use. Task Force of the European Society of Cardiology and the North American Society of Pacing and Electrophysiology publication-title: Eur Heart J – volume: 51 start-page: 2175 year: 2010 end-page: 2189 ident: bib0105 article-title: Infantile spasms: a U.S. consensus report publication-title: Epilepsia contributor: fullname: Dlugos – volume: 53 start-page: 1143 year: 2011 end-page: 1149 ident: bib0150 article-title: Autonomic effects of refractory epilepsy on heart rate variability in children: influence of intermittent vagus nerve stimulation publication-title: Dev Med Child Neurol contributor: fullname: Brown – volume: 11 start-page: 153 year: 2002 end-page: 160 ident: bib0115 article-title: Heart rate variability during sleep in children with partial epilepsy publication-title: J Sleep Res contributor: fullname: Nunes – volume: 17 start-page: 602 year: 2001 end-page: 606 ident: bib0155 article-title: Power spectrum analysis of heart rate variability in children with epilepsy publication-title: Childs Nerv Syst contributor: fullname: Lee – volume: 79 start-page: 49 year: 2008 end-page: 54 ident: bib0145 article-title: Effects of antiepileptic drug therapy on heart rate variability in children with epilepsy publication-title: Epilepsy Res contributor: fullname: Makharoblidze – volume: 53 start-page: 272 year: 2012 end-page: 282 ident: bib0130 article-title: A systematic review and meta-analysis of heart rate variability in epilepsy and antiepileptic drugs publication-title: Epilepsia contributor: fullname: Brunoni – volume: 66 start-page: 65 year: 2011 end-page: 69 ident: bib0135 article-title: Sudden unexpected death in epilepsy: an important concern publication-title: Clinics (Sao Paulo) contributor: fullname: Arida – volume: 81 start-page: 169 year: 2001 end-page: 174 ident: bib0195 article-title: Heart rate variability in healthy children and adolescents is partially related to age and gender publication-title: Int J Cardiol contributor: fullname: Ragonese – volume: 12 start-page: 966 year: 2013 end-page: 977 ident: bib0160 article-title: Incidence and mechanisms of cardiorespiratory arrests in epilepsy monitoring units (MORTEMUS): a retrospective study publication-title: Lancet Neurol contributor: fullname: Bleasel – volume: 4 start-page: 43 year: 2004 end-page: 46 ident: bib0125 article-title: Effects of seizures on autonomic and cardiovascular function publication-title: Epilepsy Curr contributor: fullname: Devinsky – volume: 25 start-page: 317 year: 2008 end-page: 320 ident: bib0200 article-title: The relationship between heart rate variability and epileptiform activity among children – a controlled study publication-title: J Clin Neurophysiol contributor: fullname: Tirosh – volume: 17 start-page: 297 year: 2008 end-page: 301 ident: bib0140 article-title: Heart rate variability in children with refractory generalized epilepsy publication-title: Seizure contributor: fullname: Kuo – volume: 18 start-page: 297 year: 1997 end-page: 302 ident: bib0190 article-title: Normal ranges of heart rate variability during infancy and childhood publication-title: Pediatr Cardiol contributor: fullname: von Bernuth – volume: 63 start-page: 131 year: 2005 end-page: 139 ident: bib0110 article-title: Time and frequency domain analyses of heart rate variability in patients with epilepsy publication-title: Epilepsy Res contributor: fullname: Unlu – volume: 47 start-page: 4 year: 2005 end-page: 9 ident: bib0120 article-title: Abnormalities in cardiac and respiratory function observed during seizures in childhood publication-title: Dev Med Child Neurol contributor: fullname: Brown – volume: 115 start-page: 377 year: 2007 end-page: 384 ident: bib0185 article-title: Non-invasive assessment of cardioregulatory autonomic functions in children with epilepsy publication-title: Acta Neurol Scand contributor: fullname: El-Ganzory – year: 2014 ident: bib0175 article-title: Can heart rate variability in children with epilepsy be used to predict seizures? publication-title: Seizure contributor: fullname: Kurt – volume: 211 start-page: 133 year: 2007 end-page: 139 ident: bib0165 article-title: Cardiac vagal activation by adrenocorticotropic hormone treatment in infants with West syndrome publication-title: Tohoku J Exp Med contributor: fullname: Kamei – volume: 66 start-page: 65 issue: Suppl. 1 year: 2011 ident: 10.1016/j.seizure.2015.02.003_bib0135 article-title: Sudden unexpected death in epilepsy: an important concern publication-title: Clinics (Sao Paulo) doi: 10.1590/S1807-59322011001300008 contributor: fullname: Scorza – year: 2014 ident: 10.1016/j.seizure.2015.02.003_bib0175 article-title: Can heart rate variability in children with epilepsy be used to predict seizures? publication-title: Seizure doi: 10.1016/j.seizure.2014.01.025 contributor: fullname: Kolsal – volume: 25 start-page: 317 issue: 5 year: 2008 ident: 10.1016/j.seizure.2015.02.003_bib0200 article-title: The relationship between heart rate variability and epileptiform activity among children – a controlled study publication-title: J Clin Neurophysiol doi: 10.1097/WNP.0b013e318182ed2d contributor: fullname: Assaf – volume: 47 start-page: 4 issue: 1 year: 2005 ident: 10.1016/j.seizure.2015.02.003_bib0120 article-title: Abnormalities in cardiac and respiratory function observed during seizures in childhood publication-title: Dev Med Child Neurol doi: 10.1111/j.1469-8749.2005.tb01033.x contributor: fullname: O’Regan – volume: 11 start-page: 153 issue: 2 year: 2002 ident: 10.1016/j.seizure.2015.02.003_bib0115 article-title: Heart rate variability during sleep in children with partial epilepsy publication-title: J Sleep Res doi: 10.1046/j.1365-2869.2002.00283.x contributor: fullname: Ferri – volume: 79 start-page: 49 issue: 1 year: 2008 ident: 10.1016/j.seizure.2015.02.003_bib0145 article-title: Effects of antiepileptic drug therapy on heart rate variability in children with epilepsy publication-title: Epilepsy Res doi: 10.1016/j.eplepsyres.2007.12.020 contributor: fullname: Hallioglu – volume: 53 start-page: 272 issue: 2 year: 2012 ident: 10.1016/j.seizure.2015.02.003_bib0130 article-title: A systematic review and meta-analysis of heart rate variability in epilepsy and antiepileptic drugs publication-title: Epilepsia doi: 10.1111/j.1528-1167.2011.03361.x contributor: fullname: Lotufo – volume: 12 start-page: 966 issue: 10 year: 2013 ident: 10.1016/j.seizure.2015.02.003_bib0160 article-title: Incidence and mechanisms of cardiorespiratory arrests in epilepsy monitoring units (MORTEMUS): a retrospective study publication-title: Lancet Neurol doi: 10.1016/S1474-4422(13)70214-X contributor: fullname: Ryvlin – volume: 17 start-page: 354 issue: 3 year: 1996 ident: 10.1016/j.seizure.2015.02.003_bib0170 article-title: Heart rate variability. Standards of measurement, physiological interpretation, and clinical, use. Task Force of the European Society of Cardiology and the North American Society of Pacing and Electrophysiology publication-title: Eur Heart J doi: 10.1093/oxfordjournals.eurheartj.a014868 – volume: 17 start-page: 297 issue: 4 year: 2008 ident: 10.1016/j.seizure.2015.02.003_bib0140 article-title: Heart rate variability in children with refractory generalized epilepsy publication-title: Seizure doi: 10.1016/j.seizure.2007.09.002 contributor: fullname: Harnod – volume: 115 start-page: 377 issue: 6 year: 2007 ident: 10.1016/j.seizure.2015.02.003_bib0185 article-title: Non-invasive assessment of cardioregulatory autonomic functions in children with epilepsy publication-title: Acta Neurol Scand doi: 10.1111/j.1600-0404.2006.00792.x contributor: fullname: El-Sayed – volume: 30 start-page: 77 issue: 1 year: 1998 ident: 10.1016/j.seizure.2015.02.003_bib0180 article-title: Heart rate variability in patients with epilepsy publication-title: Epilepsy Res doi: 10.1016/S0920-1211(97)00094-6 contributor: fullname: Tomson – volume: 18 start-page: 297 issue: 4 year: 1997 ident: 10.1016/j.seizure.2015.02.003_bib0190 article-title: Normal ranges of heart rate variability during infancy and childhood publication-title: Pediatr Cardiol doi: 10.1007/s002469900178 contributor: fullname: Massin – volume: 17 start-page: 602 issue: 10 year: 2001 ident: 10.1016/j.seizure.2015.02.003_bib0155 article-title: Power spectrum analysis of heart rate variability in children with epilepsy publication-title: Childs Nerv Syst doi: 10.1007/s003810100505 contributor: fullname: Yang – volume: 63 start-page: 131 issue: 2–3 year: 2005 ident: 10.1016/j.seizure.2015.02.003_bib0110 article-title: Time and frequency domain analyses of heart rate variability in patients with epilepsy publication-title: Epilepsy Res doi: 10.1016/j.eplepsyres.2005.02.001 contributor: fullname: Evrengul – volume: 4 start-page: 43 issue: 2 year: 2004 ident: 10.1016/j.seizure.2015.02.003_bib0125 article-title: Effects of seizures on autonomic and cardiovascular function publication-title: Epilepsy Curr doi: 10.1111/j.1535-7597.2004.42001.x contributor: fullname: Devinsky – volume: 53 start-page: 1143 issue: 12 year: 2011 ident: 10.1016/j.seizure.2015.02.003_bib0150 article-title: Autonomic effects of refractory epilepsy on heart rate variability in children: influence of intermittent vagus nerve stimulation publication-title: Dev Med Child Neurol doi: 10.1111/j.1469-8749.2011.04103.x contributor: fullname: Jansen – volume: 51 start-page: 2175 issue: 10 year: 2010 ident: 10.1016/j.seizure.2015.02.003_bib0105 article-title: Infantile spasms: a U.S. consensus report publication-title: Epilepsia doi: 10.1111/j.1528-1167.2010.02657.x contributor: fullname: Pellock – volume: 81 start-page: 169 issue: 2–3 year: 2001 ident: 10.1016/j.seizure.2015.02.003_bib0195 article-title: Heart rate variability in healthy children and adolescents is partially related to age and gender publication-title: Int J Cardiol doi: 10.1016/S0167-5273(01)00537-X contributor: fullname: Silvetti – volume: 211 start-page: 133 issue: 2 year: 2007 ident: 10.1016/j.seizure.2015.02.003_bib0165 article-title: Cardiac vagal activation by adrenocorticotropic hormone treatment in infants with West syndrome publication-title: Tohoku J Exp Med doi: 10.1620/tjem.211.133 contributor: fullname: Hattori |
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| Snippet | Highlights • During hypsarrhythmia the WS-patients had significantly lower heart rate variability. • At the final examination the patients no longer differed... •During hypsarrhythmia the WS-patients had significantly lower heart rate variability.•At the final examination the patients no longer differed from the... West syndrome (WS) is a severe age-related acute epileptic encephalopathy of infancy characterized by infantile spasms, hypsarrhythmia and psychomotor delay.... PURPOSEWest syndrome (WS) is a severe age-related acute epileptic encephalopathy of infancy characterized by infantile spasms, hypsarrhythmia and psychomotor... |
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| SubjectTerms | Analysis of Variance Autonomic function Case-Control Studies Electrocardiography Electroencephalography Female Heart Rate - physiology Heart rate variability Humans Hypsarrhythmia Infant Infantile spasms Male Neurology Retrospective Studies Spasms, Infantile - physiopathology Statistics, Nonparametric West syndrome |
| Title | Heart rate variability in infants with West syndrome |
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