Caenorhabditis elegans: A Useful Model for Studying Metabolic Disorders in Which Oxidative Stress Is a Contributing Factor

Caenorhabditis elegans: A Useful Model for Studying Metabolic Disorders in Which Oxidative Stress Is a Contributing Factor

Caenorhabditis elegans is a powerful model organism that is invaluable for experimental research because it can be used to recapitulate most human diseases at either the metabolic or genomic level in vivo. This organism contains many key components related to metabolic and oxidative stress networks...

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Published in:Oxidative medicine and cellular longevity Vol. 2014; no. 2014; pp. 1 - 9
Main Authors: Carmona-Aparicio, Liliana, Pedraza-Chaverri, José, Coballase-Urrutia, Elvia, Cárdenas-Rodríguez, Noemí, Moreno-Arriola, Elizabeth, Ortega-Cuellar, Daniel
Format: Journal Article
Language:English
Published: Cairo, Egypt Hindawi Publishing Corporation 01-01-2014
John Wiley & Sons, Inc
Subjects:
Analysis
Animals
Caenorhabditis elegans
Caenorhabditis elegans - metabolism
Disease Models, Animal
Health aspects
Humans
Metabolic diseases
Metabolic Diseases - pathology
Oxidative Stress
Reactive Oxygen Species - metabolism
Review
Second Messenger Systems
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Abstract Caenorhabditis elegans is a powerful model organism that is invaluable for experimental research because it can be used to recapitulate most human diseases at either the metabolic or genomic level in vivo. This organism contains many key components related to metabolic and oxidative stress networks that could conceivably allow us to increase and integrate information to understand the causes and mechanisms of complex diseases. Oxidative stress is an etiological factor that influences numerous human diseases, including diabetes. C. elegans displays remarkably similar molecular bases and cellular pathways to those of mammals. Defects in the insulin/insulin-like growth factor-1 signaling pathway or increased ROS levels induce the conserved phase II detoxification response via the SKN-1 pathway to fight against oxidative stress. However, it is noteworthy that, aside from the detrimental effects of ROS, they have been proposed as second messengers that trigger the mitohormetic response to attenuate the adverse effects of oxidative stress. Herein, we briefly describe the importance of C. elegans as an experimental model system for studying metabolic disorders related to oxidative stress and the molecular mechanisms that underlie their pathophysiology.
AbstractList Caenorhabditis elegans is a powerful model organism that is invaluable for experimental research because it can be used to recapitulate most human diseases at either the metabolic or genomic level in vivo. This organism contains many key components related to metabolic and oxidative stress networks that could conceivably allow us to increase and integrate information to understand the causes and mechanisms of complex diseases. Oxidative stress is an etiological factor that influences numerous human diseases, including diabetes. C. elegans displays remarkably similar molecular bases and cellular pathways to those of mammals. Defects in the insulin/insulin-like growth factor-1 signaling pathway or increased ROS levels induce the conserved phase II detoxification response via the SKN-1 pathway to fight against oxidative stress. However, it is noteworthy that, aside from the detrimental effects of ROS, they have been proposed as second messengers that trigger the mitohormetic response to attenuate the adverse effects of oxidative stress. Herein, we briefly describe the importance of C. elegans as an experimental model system for studying metabolic disorders related to oxidative stress and the molecular mechanisms that underlie their pathophysiology.
Caenorhabditis elegans is a powerful model organism that is invaluable for experimental research because it can be used to recapitulate most human diseases at either the metabolic or genomic level in vivo . This organism contains many key components related to metabolic and oxidative stress networks that could conceivably allow us to increase and integrate information to understand the causes and mechanisms of complex diseases. Oxidative stress is an etiological factor that influences numerous human diseases, including diabetes. C. elegans displays remarkably similar molecular bases and cellular pathways to those of mammals. Defects in the insulin/insulin-like growth factor-1 signaling pathway or increased ROS levels induce the conserved phase II detoxification response via the SKN-1 pathway to fight against oxidative stress. However, it is noteworthy that, aside from the detrimental effects of ROS, they have been proposed as second messengers that trigger the mitohormetic response to attenuate the adverse effects of oxidative stress. Herein, we briefly describe the importance of C. elegans as an experimental model system for studying metabolic disorders related to oxidative stress and the molecular mechanisms that underlie their pathophysiology.
Audience Academic
Author Pedraza-Chaverri, José
Coballase-Urrutia, Elvia
Carmona-Aparicio, Liliana
Moreno-Arriola, Elizabeth
Cárdenas-Rodríguez, Noemí
Ortega-Cuellar, Daniel
AuthorAffiliation 2 Laboratory of Neurochemistry, National Institute of Pediatrics, 04530 Mexico City, DF, Mexico
1 Laboratory of Experimental Nutrition, National Institute of Pediatrics, 04530 Mexico City, DF, Mexico
3 Department of Biology, Faculty of Chemistry, University City, UNAM, 04150 Mexico City, DF, Mexico
AuthorAffiliation_xml – name: 2 Laboratory of Neurochemistry, National Institute of Pediatrics, 04530 Mexico City, DF, Mexico
– name: 1 Laboratory of Experimental Nutrition, National Institute of Pediatrics, 04530 Mexico City, DF, Mexico
– name: 3 Department of Biology, Faculty of Chemistry, University City, UNAM, 04150 Mexico City, DF, Mexico
Author_xml – sequence: 1
  fullname: Carmona-Aparicio, Liliana
– sequence: 2
  fullname: Pedraza-Chaverri, José
– sequence: 3
  fullname: Coballase-Urrutia, Elvia
– sequence: 4
  fullname: Cárdenas-Rodríguez, Noemí
– sequence: 5
  fullname: Moreno-Arriola, Elizabeth
– sequence: 6
  fullname: Ortega-Cuellar, Daniel
BackLink https://www.ncbi.nlm.nih.gov/pubmed/24955209$$D View this record in MEDLINE/PubMed
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Snippet Caenorhabditis elegans is a powerful model organism that is invaluable for experimental research because it can be used to recapitulate most human diseases at...
Caenorhabditis elegans is a powerful model organism that is invaluable for experimental research because it can be used to recapitulate most human diseases at...
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SubjectTerms Analysis
Animals
Caenorhabditis elegans
Caenorhabditis elegans - metabolism
Disease Models, Animal
Health aspects
Humans
Metabolic diseases
Metabolic Diseases - pathology
Oxidative Stress
Reactive Oxygen Species - metabolism
Review
Second Messenger Systems
Title Caenorhabditis elegans: A Useful Model for Studying Metabolic Disorders in Which Oxidative Stress Is a Contributing Factor
URI https://search.emarefa.net/detail/BIM-1047092
https://dx.doi.org/10.1155/2014/705253
https://www.ncbi.nlm.nih.gov/pubmed/24955209
https://search.proquest.com/docview/1551021235
https://pubmed.ncbi.nlm.nih.gov/PMC4052186
Volume 2014
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