Adjunctive Hyperbaric Oxygen Therapy promotes successful healing in patients with refractory Crohn's disease

• Published in: Acta cirurgica brasileira Vol. 31 Suppl 1; no. suppl 1; pp. 19 - 23
• Main Authors: Feitosa, Marley Ribeiro, Féres Filho, Omar, Tamaki, Camila Mussolin, Perazzoli, Camila, Bernardes, Mário Vinícius Angelete Alvarez, Parra, Rogério Serafim, Rocha, José Joaquim Ribeiro da, Féres, Omar
• Format: Journal Article
• Language: English
• Published: Brazil Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia 2016
• Subjects: Adult; Aged; Child; Combined Modality Therapy; Crohn Disease; Crohn Disease - therapy; Cutaneous Fistula; Female; Humans; Hyperbaric Oxygenation; Hyperbaric Oxygenation - methods; Hyperbaric Oxygenation - statistics & numerical data; Intestinal Fistula - therapy; Male; Middle Aged; Prospective Studies; Pyoderma Gangrenosum; Pyoderma Gangrenosum - therapy; Reproducibility of Results; Time Factors; Treatment Outcome; Wound Healing; Young Adult
• ISSN: 0102-8650; 1678-2674; 0102-8650
• DOI: 10.1590/S0102-86502016001300005

To investigate de adjunctive effect of Hyperbaric Oxygen Therapy in a group of patients with refractory Crohn's disease.
A total of 29 subjects with refractory Crohn's disease were submitted to daily sessions of Hyperbaric Oxygen Therapy, in a 2800 Sechrist Monoplace Hyperbaric Chamber (Sechrist, USA) pressurized to 2.4 ATA. Each session lasted 2 hours. The endpoint was closure of enterocutaneous fistulas and complete healing of Pyoderma Gangrenosum and perineal Crohn's disease.
A total of 829 HBOT sessions were performed and no complications were noted. Overall success rate was 76% (22 cases). Pyoderma Gangrenosum and enterocutaneous fistulas had the highest successful healing rates (100% and 91%, respectively). Perineal Crohn's disease healing rate was 65%.
Adjunctive Hyperbaric Oxygen Therapy promoted satisfactory healing in a group of patients with refractory Crohn's disease.