Hyperfunctioning malignant thyroid nodule in an 11-year-old girl: Pathologic and molecular studies

We identified a papillary carcinoma in an 11-year-old girl with a hyperfunctioning thyroid nodule. A met453thr mutation in TSHR was found in the nodule but not in normal thyroid tissue or in leukocytes. This case documents that this activating mutation is associated with neoplasia. (J Pediatr 2000;1...

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Bibliographic Details
Published in:	The Journal of pediatrics Vol. 137; no. 4; pp. 585 - 587
Main Authors:	Mircescu, Hortensia, Parma, Jasmine, Huot, Céline, Deal, Cheri, Oligny, Luc L., Vassart, Gilbert, Van Vliet, Guy
Format:	Journal Article
Language:	English
Published:	New York, NY Mosby, Inc 01-10-2000 Elsevier
Subjects:	Biological and medical sciences Carcinoma, Papillary Child Endocrinopathies Female Humans Malignant tumors Medical sciences Mutation Thyroid Neoplasms - complications Thyroid Nodule - complications Thyroid Nodule - genetics Thyroid Nodule - pathology Thyroid. Thyroid axis (diseases) Endocrinopathy Human Papillary carcinoma Hyperthyroidism Thyroid diseases Thyroid stimulating hormone Thyroid gland Malignant tumor Genetic determinism Case study Adenohypophyseal hormone Female Mutation Molecular biology Child Hormonal receptor
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Summary:	We identified a papillary carcinoma in an 11-year-old girl with a hyperfunctioning thyroid nodule. A met453thr mutation in TSHR was found in the nodule but not in normal thyroid tissue or in leukocytes. This case documents that this activating mutation is associated with neoplasia. (J Pediatr 2000;137:585-7)
Bibliography:	ObjectType-Case Study-3 SourceType-Scholarly Journals-1 content type line 23 ObjectType-Review-1 ObjectType-Feature-5 ObjectType-Report-2 ObjectType-Article-4
ISSN:	0022-3476 1097-6833
DOI:	10.1067/mpd.2000.108437