Riboflavin deficiency caused by treatment with adriamycin [to rats]

• Published in: Journal of Nutritional Science and Vitaminology Vol. 37; no. 5; pp. 473 - 477
• Main Authors: Ogura, R. (Kurume Univ., Fukuoka (Japan). School of Medicine), Ueta, Y, Hino, Y, Hidaka, T, Sugiyama, M
• Format: Journal Article
• Language: English
• Published: Japan Center for Academic Publications Japan 01-10-1991
• Subjects: adriamycin; Animals; ANTIBIOTICOS; ANTIBIOTICS; ANTIBIOTIQUE; CARENCE EN VITAMINE; DEFICIENCIA DE VITAMINAS; Doxorubicin - administration & dosage; Doxorubicin - adverse effects; Flavins - blood; Flavins - urine; glutathione reductase; Glutathione Reductase - blood; heart mitochondria; lipid peroxide; Lipid Peroxides - blood; Male; Mitochondria, Heart - chemistry; RAT; RATA; RATS; Rats, Inbred Strains; RIBOFLAVIN; Riboflavin Deficiency - chemically induced; RIBOFLAVINA; RIBOFLAVINE; urinary excretion; VITAMIN DEFICIENCIES
• ISSN: 0301-4800; 1881-7742
• DOI: 10.3177/jnsv.37.473

The present study was undertaken to determine whether administration of adriamycin causes the depletion of riboflavin content. Rats received intraperitoneal injections of adriamycin (4mg per kg body weight) for 6 consecutive days. Urinary riboflavin excretion began to increase after 2 days of treatment with adriamycin. Erythrocyte FAD levels decreased gradually and plasma lipid peroxide contents increased markedly at the 6th day. The activity coefficient of erythrocyte glutathione reductase showed a significant increase before the decrease of flavin content and the elevation of lipid peroxide level. Therefore, the value of this coefficient obtained from erythrocyte appears to be a reliable index of riboflavin deficiency, particularly during the early stage.