Role of Oxidative Metabolism in the Effect of Valproic Acid on Markers of Cell Viability, Necrosis, and Oxidative Stress in Sandwich-Cultured Rat Hepatocytes

Valproic acid (VPA) is a drug known for idiosyncratic hepatotoxicity and is associated with oxidative stress. It is metabolized extensively with at least one pathway leading to reactive metabolites. The primary aim of the present study was to determine whether oxidative metabolites of VPA generated...

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Bibliographic Details
Published in:	Toxicological sciences Vol. 118; no. 2; pp. 501 - 509
Main Authors:	Kiang, Tony K. L., Teng, Xiao Wei, Karagiozov, Stoyan, Surendradoss, Jayakumar, Chang, Thomas K. H., Abbott, Frank S.
Format:	Journal Article
Language:	English
Published:	United States Oxford University Press 01-12-2010
Subjects:	Animals Biomarkers - metabolism Cell Culture Techniques - methods Cell Survival - drug effects Cells, Cultured Cytochrome cytotoxicity Dose-Response Relationship, Drug Energy Metabolism Enzyme Inhibitors - pharmacokinetics Enzyme Inhibitors - toxicity hepatocytes Hepatocytes - drug effects Hepatocytes - metabolism L-Lactate Dehydrogenase - metabolism Male metabolism Necrosis - chemically induced Oxidation-Reduction oxidative stress Oxidative Stress - drug effects Rats Rats, Sprague-Dawley reactive metabolites tert-Butylhydroperoxide - toxicity valproic acid Valproic Acid - analogs & derivatives Valproic Acid - pharmacokinetics Valproic Acid - toxicity
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