Towards an integrated model of bacterial conjugation

Towards an integrated model of bacterial conjugation

Bacterial conjugation is one of the main mechanisms for horizontal gene transfer. It constitutes a key element in the dissemination of antibiotic resistance and virulence genes to human pathogenic bacteria. DNA transfer is mediated by a membrane-associated macromolecular machinery called Type IV sec...

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Published in:FEMS microbiology reviews Vol. 39; no. 1; pp. 81 - 95
Main Authors: Cabezón, Elena, Ripoll-Rozada, Jorge, Peña, Alejandro, de la Cruz, Fernando, Arechaga, Ignacio
Format: Journal Article
Language:English
Published: England Oxford University Press 01-01-2015
Subjects:
Antibiotic resistance
Antibiotics
Bacteria
Bacteria - genetics
Bacteria - metabolism
Bacterial Proteins - metabolism
Bacterial Secretion Systems - physiology
Conjugation
Conjugation, Genetic - genetics
Conjugation, Genetic - physiology
Deoxyribonucleic acid
DNA
DNA, Bacterial - genetics
Drug resistance
Gene transfer
Horizontal transfer
Macromolecules
Models, Biological
Molecular modelling
Protein Transport
Substrates
Virulence
Virulence factors
bacterial conjugation
secretion systems
antibiotic resistance
horizontal gene transfer
macromolecular assemblies
pilus biogenesis
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Abstract Bacterial conjugation is one of the main mechanisms for horizontal gene transfer. It constitutes a key element in the dissemination of antibiotic resistance and virulence genes to human pathogenic bacteria. DNA transfer is mediated by a membrane-associated macromolecular machinery called Type IV secretion system (T4SS). T4SSs are involved not only in bacterial conjugation but also in the transport of virulence factors by pathogenic bacteria. Thus, the search for specific inhibitors of different T4SS components opens a novel approach to restrict plasmid dissemination. This review highlights recent biochemical and structural findings that shed new light on the molecular mechanisms of DNA and protein transport by T4SS. Based on these data, a model for pilus biogenesis and substrate transfer in conjugative systems is proposed. This model provides a renewed view of the mechanism that might help to envisage new strategies to curb the threating expansion of antibiotic resistance. Bacterial conjugation is one of the main mechanisms for the dissemination of antibiotic resistance genes. Here, we suggest a model that integrates the mechanism of conjugation with Type IV secretions systems biogenesis and substrate transport across the secretion channel and we propose alternative approaches to use this knowledge in the fight against the spread of antibiotic resistance.
AbstractList Bacterial conjugation is one of the main mechanisms for horizontal gene transfer. It constitutes a key element in the dissemination of antibiotic resistance and virulence genes to human pathogenic bacteria. DNA transfer is mediated by a membrane-associated macromolecular machinery called Type IV secretion system (T4SS). T4SSs are involved not only in bacterial conjugation but also in the transport of virulence factors by pathogenic bacteria. Thus, the search for specific inhibitors of different T4SS components opens a novel approach to restrict plasmid dissemination. This review highlights recent biochemical and structural findings that shed new light on the molecular mechanisms of DNA and protein transport by T4SS. Based on these data, a model for pilus biogenesis and substrate transfer in conjugative systems is proposed. This model provides a renewed view of the mechanism that might help to envisage new strategies to curb the threating expansion of antibiotic resistance.
Bacterial conjugation is one of the main mechanisms for horizontal gene transfer. It constitutes a key element in the dissemination of antibiotic resistance and virulence genes to human pathogenic bacteria. DNA transfer is mediated by a membrane-associated macromolecular machinery called Type IV secretion system (T4SS). T4SSs are involved not only in bacterial conjugation but also in the transport of virulence factors by pathogenic bacteria. Thus, the search for specific inhibitors of different T4SS components opens a novel approach to restrict plasmid dissemination. This review highlights recent biochemical and structural findings that shed new light on the molecular mechanisms of DNA and protein transport by T4SS. Based on these data, a model for pilus biogenesis and substrate transfer in conjugative systems is proposed. This model provides a renewed view of the mechanism that might help to envisage new strategies to curb the threating expansion of antibiotic resistance. Bacterial conjugation is one of the main mechanisms for the dissemination of antibiotic resistance genes. Here, we suggest a model that integrates the mechanism of conjugation with Type IV secretions systems biogenesis and substrate transport across the secretion channel and we propose alternative approaches to use this knowledge in the fight against the spread of antibiotic resistance.
Author Peña, Alejandro
de la Cruz, Fernando
Ripoll-Rozada, Jorge
Cabezón, Elena
Arechaga, Ignacio
Author_xml – sequence: 1
  givenname: Elena
  surname: Cabezón
  fullname: Cabezón, Elena
  organization: 1Departamento de Biología Molecular, Instituto de Biomedicina y Biotecnología de Cantabria, IBBTEC, (Universidad de Cantabria, CSIC) Santander, Spain
– sequence: 2
  givenname: Jorge
  surname: Ripoll-Rozada
  fullname: Ripoll-Rozada, Jorge
  organization: 1Departamento de Biología Molecular, Instituto de Biomedicina y Biotecnología de Cantabria, IBBTEC, (Universidad de Cantabria, CSIC) Santander, Spain
– sequence: 3
  givenname: Alejandro
  surname: Peña
  fullname: Peña, Alejandro
  organization: 1Departamento de Biología Molecular, Instituto de Biomedicina y Biotecnología de Cantabria, IBBTEC, (Universidad de Cantabria, CSIC) Santander, Spain
– sequence: 4
  givenname: Fernando
  surname: de la Cruz
  fullname: de la Cruz, Fernando
  organization: 1Departamento de Biología Molecular, Instituto de Biomedicina y Biotecnología de Cantabria, IBBTEC, (Universidad de Cantabria, CSIC) Santander, Spain
– sequence: 5
  givenname: Ignacio
  surname: Arechaga
  fullname: Arechaga, Ignacio
  email: arechagai@unican.es
  organization: 1Departamento de Biología Molecular, Instituto de Biomedicina y Biotecnología de Cantabria, IBBTEC, (Universidad de Cantabria, CSIC) Santander, Spain
BackLink https://www.ncbi.nlm.nih.gov/pubmed/25154632$$D View this record in MEDLINE/PubMed
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ID FETCH-LOGICAL-c467t-423f57295d6d4aa4c1797d4ac2ceebec2033d0c3aadf7d88ac40d0eaf1b446d03
ISSN 0168-6445
IngestDate Fri Oct 25 12:19:29 EDT 2024
Tue Nov 19 03:38:07 EST 2024
Thu Nov 21 22:00:36 EST 2024
Tue Oct 15 23:49:03 EDT 2024
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Issue 1
Keywords bacterial conjugation
secretion systems
antibiotic resistance
horizontal gene transfer
macromolecular assemblies
pilus biogenesis
Language English
License FEMS 2015. All rights reserved. For permissions, please e-mail: journals.permission@oup.com.
LinkModel OpenURL
MergedId FETCHMERGED-LOGICAL-c467t-423f57295d6d4aa4c1797d4ac2ceebec2033d0c3aadf7d88ac40d0eaf1b446d03
Notes ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
OpenAccessLink https://academic.oup.com/femsre/article-pdf/39/1/81/10741187/12085.pdf
PMID 25154632
PQID 2332077066
PQPubID 986349
PageCount 15
ParticipantIDs proquest_miscellaneous_1684435007
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crossref_primary_10_1111_1574_6976_12085
pubmed_primary_25154632
oup_primary_10_1111_1574-6976_12085
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PublicationDate 2015-01-01
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  year: 2015
  text: 2015-01-01
  day: 01
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PublicationPlace England
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– name: Delft
PublicationTitle FEMS microbiology reviews
PublicationTitleAlternate FEMS Microbiol Rev
PublicationYear 2015
Publisher Oxford University Press
Publisher_xml – name: Oxford University Press
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Snippet Bacterial conjugation is one of the main mechanisms for horizontal gene transfer. It constitutes a key element in the dissemination of antibiotic resistance...
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SubjectTerms Antibiotic resistance
Antibiotics
Bacteria
Bacteria - genetics
Bacteria - metabolism
Bacterial Proteins - metabolism
Bacterial Secretion Systems - physiology
Conjugation
Conjugation, Genetic - genetics
Conjugation, Genetic - physiology
Deoxyribonucleic acid
DNA
DNA, Bacterial - genetics
Drug resistance
Gene transfer
Horizontal transfer
Macromolecules
Models, Biological
Molecular modelling
Protein Transport
Substrates
Virulence
Virulence factors
Title Towards an integrated model of bacterial conjugation
URI https://www.ncbi.nlm.nih.gov/pubmed/25154632
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