Beneficial Effect of Shikonin on Experimental Colitis Induced by Dextran Sulfate Sodium in Balb/C Mice

The naphthoquinone shikonin, a major component of the root of Lithospermum erythrorhizon, now is studied as an anti-inflammatory agent in the treatment of ulcerative colitis (UC). Acute UC was induced in Balb/C mice by oral administration of 5% dextran sodium sulfate (DSS). The disease activity inde...

Full description

Saved in:

Bibliographic Details
Published in:	Evidence-based complementary and alternative medicine Vol. 2012; no. 2012; pp. 1 - 15
Main Authors:	Miguel Cerdá, José, Giner, Rosa María, Ríos, José Luis, Andújar, Isabel, Recio, María del Carmen
Format:	Journal Article
Language:	English
Published:	Cairo, Egypt Hindawi Publishing Corporation 01-01-2012 Hindawi Limited
Subjects:	Activation Cancer therapies Chemical compounds Colon Cyclooxygenase-2 Cytokines Dextran Dextran sulfate Gastroenterology Immune system Inflammation Inflammatory bowel disease Inflammatory bowel diseases Interleukin 6 Intestine Lithospermum erythrorhizon Macrophages Mice NF-κB protein Oral administration Peroxidase Polyphenols Prostaglandin endoperoxide synthase Rodents Shikonin Sodium Sodium sulfate Stat3 protein Stools Sulfates Transcription factors Tumor necrosis factor Tumor necrosis factor-TNF Tumor necrosis factor-α Ulcerative colitis
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Be the first to leave a comment!