A phase I and pharmacokinetic study of MAG-CPT, a water-soluble polymer conjugate of camptothecin

Polymeric drug conjugates are a new and experimental class of drug delivery systems with pharmacokinetic promises. The antineoplastic drug camptothecin was linked to a water-soluble polymeric backbone (MAG-CPT) and administrated as a 30 min infusion over 3 consecutive days every 4 weeks to patients...

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Bibliographic Details
Published in:	British journal of cancer Vol. 87; no. 6; pp. 608 - 614
Main Authors:	SCHOEMAKER, N. E, VAN KESTEREN, C, GRAZIA PORRO, M, BEIJNEN, J. H, SCHELLENS, J. H. M, TEN BOKKEL HUININK, W. W, ROSING, H, JANSEN, S, SWART, M, LIEVERST, J, FRAIER, D, BREDA, M, PELLIZZONI, C, SPINELLI, R
Format:	Journal Article
Language:	English
Published:	Basingstoke Nature Publishing Group 09-09-2002
Subjects:	Acrylamides - administration & dosage Acrylamides - adverse effects Acrylamides - chemistry Acrylamides - pharmacokinetics Adult Aged Antineoplastic agents Antineoplastic Agents, Phytogenic - administration & dosage Antineoplastic Agents, Phytogenic - adverse effects Antineoplastic Agents, Phytogenic - pharmacokinetics Biological and medical sciences Camptothecin - administration & dosage Camptothecin - adverse effects Camptothecin - pharmacokinetics Chemotherapy Clinical Female Hematologic Diseases - chemically induced Humans Male Maximum Tolerated Dose Medical sciences Middle Aged Neoplasms - drug therapy Pharmacology. Drug treatments Urinary Bladder Diseases - chemically induced Antineoplastic agent Human Enzyme Maximal dose Controlled release form DNA topoisomerase Enzyme inhibitor Polymer Malignant tumor Biological activity Water soluble compound Alkaloid Chemotherapy Isomerases Limit dose Treatment Phase I trial Dosage form Conjugation Pharmacokinetics
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