Carnitine, acylcarnitine and amino acid profiles analyzed by tandem mass spectrometry in a surfactant/virus mouse model of acute hepatic encephalopathy

Tandem mass spectrometry (MS/MS) was used to analyze multiple serum metabolites for the first time in a surfactant/virus mouse model of acute hepatic encephalopathy (AHE). AHE is characterized by acute liver failure that can lead to potentially lethal increases in intracranial pressure. We have repr...

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Bibliographic Details
Published in:	Chemosphere (Oxford) Vol. 68; no. 9; pp. 1692 - 1698
Main Authors:	Murphy, M.G., Crocker, J.F.S., O’Regan, P., Lee, S.H.S., Geldenhuys, L., Dooley, K., Al-Khalidi, M., Acott, P.D.
Format:	Journal Article
Language:	English
Published:	Oxford Elsevier Ltd 01-08-2007 Elsevier
Subjects:	Acute hepatic encephalopathy Amino Acids - blood Amino Acids - chemistry Animals Biological and medical sciences Carnitine - analogs & derivatives Carnitine - blood Carnitine - chemistry Dicarboxylic acylcarnitine Disease Models, Animal Gastroenterology. Liver. Pancreas. Abdomen Hepatic Encephalopathy - blood Hepatic Encephalopathy - chemically induced Hepatic Encephalopathy - virology Hydroxy-acylcarnitine Industrial surfactant Influenza B virus - physiology Lee virus Liver. Biliary tract. Portal circulation. Exocrine pancreas Medical sciences Mice Mouse-adapted human influenza B (Lee) virus Other diseases. Semiology Surface-Active Agents - toxicity Tandem Mass Spectrometry Time Factors Toximul 3409F RS Mouse-adapted human influenza B (Lee) virus Industrial surfactant Dicarboxylic acylcarnitine Cn: x-DC MS/MS VLCAD Cn: x-OH FluB Toximul 3409F MEM FAO Acute hepatic encephalopathy LCHAD Hydroxy-acylcarnitine Tox Acylcarnitine nomenclature: Cn: x MCAD AHE DC Animal model Toxicity Liver Hepatic disease Surfactant Modeling Liver failure Mitochondria Encephalopathy Human Acute Rodentia Carnitine Virus Vertebrata Mammalia Mouse Aminoacid Animal Mass spectrometry MS/MS Digestive diseases
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