Using network science tools to identify novel diet patterns in prodromal dementia

• Published in: Neurology Vol. 94; no. 19; pp. e2014 - e2025
• Main Authors: Samieri, Cécilia, Sonawane, Abhijeet Rajendra, Lefèvre-Arbogast, Sophie, Helmer, Catherine, Grodstein, Francine, Glass, Kimberly
• Format: Journal Article
• Language: English
• Published: United States American Academy of Neurology 12-05-2020
• Subjects: Aged; Case-Control Studies; Dementia - psychology; Feeding Behavior - psychology; Female; Humans; Male; Nonlinear Dynamics; Prodromal Symptoms
• ISSN: 0028-3878; 1526-632X; 1526-632X
• DOI: 10.1212/WNL.0000000000009399

OBJECTIVETo use network science to model complex diet relationships a decade before onset of dementia in a large French cohort, the 3-City Bordeaux study.
METHODSWe identified cases of dementia incident to the baseline food frequency questionnaire over 12 years of follow-up. For each case, we randomly selected 2 controls among individuals at risk at the age at case diagnosis and matched for age at diet assessment, sex, education, and season of the survey. We inferred food networks in both cases and controls using mutual information, a measure to detect nonlinear associations, and compared food consumption patterns between groups.
RESULTSIn the nested case-control study, the mean (SD) duration of follow-up and number of visits were 5.0 (2.5) vs 4.9 (2.6) years and 4.1 (1.0) vs 4.4 (0.9) for cases (n = 209) vs controls (n = 418), respectively. While there were few differences in simple, average food intakes, food networks differed substantially between cases and controls. The network in cases was focused and characterized by charcuterie as the main hub, with connections to foods typical of French southwestern diet and snack foods. In contrast, the network of controls included several disconnected subnetworks reflecting diverse and healthier food choices.
CONCLUSIONHow foods are consumed (and not only the quantity consumed) may be important for dementia prevention. Differences in predementia diet networks, suggesting worse eating habits toward charcuterie and snacking, were evident years before diagnosis in this cohort. Network methods, which are designed to model complex systems, may advance our understanding of risk factors for dementia.