iNOS inhibitor, L-NIL, reverses burn-induced glycogen synthase kinase-3β activation in skeletal muscle of rats

Abstract Objectives Recent studies suggest that activation of glycogen synthase kinase (GSK)-3β may be involved in burn injury-induced metabolic derangements and protein breakdown in skeletal muscle. However, the mechanism for GSK-3β activation after burn injury is unknown. To investigate the role o...

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Bibliographic Details
Published in:	Metabolism, clinical and experimental Vol. 62; no. 3; pp. 341 - 346
Main Authors:	Kaneki, Masao, Fukushima, Yuji, Shinozaki, Shohei, Fukaya, Makiko, Habiro, Mayu, Shimizu, Nobuyuki, Chang, Kyungho, Yasuhara, Shingo, Martyn, J.A. Jeevendra
Format:	Journal Article
Language:	English
Published:	New York, NY Elsevier Inc 01-03-2013 Elsevier
Subjects:	Akt/PKB Animals Biological and medical sciences Burns Burns - enzymology Burns - metabolism Endocrinology & Metabolism Enzyme Activation - drug effects Enzyme Inhibitors - pharmacology Feeding. Feeding behavior Fundamental and applied biological sciences. Psychology Glycogen Synthase - metabolism Glycogen Synthase Kinase 3 - metabolism Glycogen Synthase Kinase 3 beta Lysine - analogs & derivatives Lysine - pharmacology Male Medical sciences Muscle, Skeletal - drug effects Muscle, Skeletal - enzymology Muscle, Skeletal - injuries Muscle, Skeletal - metabolism Nitric Oxide Synthase Type II - antagonists & inhibitors Nitric Oxide Synthase Type II - metabolism Phosphorylation Random Allocation Rats Rats, Sprague-Dawley Traumas. Diseases due to physical agents Vertebrates: anatomy and physiology, studies on body, several organs or systems PBS GSK-3β L-NIL Akt/PKB glycogen synthase kinase-3β N 6-(1-iminoethyl)-l-lysine glycogen synthase iNOS phosphate-buffered saline GS inducible nitric-oxide synthase Rat Enzyme Transferases Rodentia Activation Striated muscle Burn Vertebrata Mammalia Glycogen synthase kinase-3β Animal Inhibitor Endocrinology
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