NGS in Lung, Breast, and Unknown Primary Cancer in Colombia: A Multidisciplinary Consensus on Challenges and Opportunities
Given the benefits and likely future applications, there is an urgent need to expand the use of next-generation sequencing (NGS) in breast, lung, and unknown primary cancers in Colombia. The objective of this review is to address the barriers limiting access to the use of NGS in Colombia, specifical...
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| Published in: | JCO global oncology Vol. 7; no. 7; pp. 1012 - 1023 |
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| Main Authors: | , , , , , |
| Format: | Journal Article |
| Language: | English |
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Wolters Kluwer Health
01-12-2021
American Society of Clinical Oncology |
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| Abstract | Given the benefits and likely future applications, there is an urgent need to expand the use of next-generation sequencing (NGS) in breast, lung, and unknown primary cancers in Colombia. The objective of this review is to address the barriers limiting access to the use of NGS in Colombia, specifically for patients with breast, lung, and unknown primary cancers in the public health care system. A selected Panel of Colombian experts in NGS were provided with a series of relevant questions to address in a multiday conference. Each narrative was discussed and edited by the Panel through numerous drafts and rounds of discussion until consensus was achieved. There are limitations to the widespread adoption of innovative technology inherent to the Colombian health care system. Barriers identified to implementing NGS in Colombia include availability, accessibility, and affordability; limited infrastructure; training and awareness of health personnel; quality-control procedures; and collection of local data. Stakeholders must align to adapt the implementation of NGS to the constraints of resource-limited environments. Diagnostic algorithms were developed to guide molecular testing for lung, breast, and unknown primary cancers. Recommendations on overcoming the barriers to the widespread adoption of NGS include country-specific molecular testing guidelines, creating a national genetic registry, improving infrastructure, and creating health policy that favors the adoption of innovative technology. |
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| AbstractList | Given the benefits and likely future applications, there is an urgent need to expand the use of next-generation sequencing (NGS) in breast, lung, and unknown primary cancers in Colombia. The objective of this review is to address the barriers limiting access to the use of NGS in Colombia, specifically for patients with breast, lung, and unknown primary cancers in the public health care system. A selected Panel of Colombian experts in NGS were provided with a series of relevant questions to address in a multiday conference. Each narrative was discussed and edited by the Panel through numerous drafts and rounds of discussion until consensus was achieved. There are limitations to the widespread adoption of innovative technology inherent to the Colombian health care system. Barriers identified to implementing NGS in Colombia include availability, accessibility, and affordability; limited infrastructure; training and awareness of health personnel; quality-control procedures; and collection of local data. Stakeholders must align to adapt the implementation of NGS to the constraints of resource-limited environments. Diagnostic algorithms were developed to guide molecular testing for lung, breast, and unknown primary cancers. Recommendations on overcoming the barriers to the widespread adoption of NGS include country-specific molecular testing guidelines, creating a national genetic registry, improving infrastructure, and creating health policy that favors the adoption of innovative technology. |
| Author | Baldion, Ana Margarita Sua, Luz F. Sanabria-Salas, María Carolina Gonzalez, Diego Mauricio Lema, Mauricio Mantilla, William Armando |
| Author_xml | – sequence: 1 givenname: William Armando orcidid: 0000-0002-2778-164X surname: Mantilla fullname: Mantilla, William Armando organization: Fundacion Cardioinfantil, Universidad del Rosario, Bogotá, Colombia – sequence: 2 givenname: María Carolina orcidid: 0000-0002-7946-2026 surname: Sanabria-Salas fullname: Sanabria-Salas, María Carolina organization: Instituto Nacional de Cancerología, Bogotá, Colombia – sequence: 3 givenname: Ana Margarita surname: Baldion fullname: Baldion, Ana Margarita organization: Head of the Pathology Section, Department of Pathology and Laboratory Medicine, Hospital Universitario Fundacion Santa Fe de Bogota, Bogotá, Colombia – sequence: 4 givenname: Luz F. orcidid: 0000-0001-9574-2370 surname: Sua fullname: Sua, Luz F. organization: Department of Pathology and Laboratory Medicine, Fundación Valle del Lili, and Faculty of Health Sciences, Universidad ICESI, Cali, Colombia – sequence: 5 givenname: Diego Mauricio orcidid: 0000-0003-0907-7197 surname: Gonzalez fullname: Gonzalez, Diego Mauricio organization: Instituto de Cancerología Las Americas-AUNA, Universidad de Antioquia, Antioquia, Colombia – sequence: 6 givenname: Mauricio orcidid: 0000-0001-9346-0361 surname: Lema fullname: Lema, Mauricio organization: Clínica de Oncología Astorga, Medellín, Colombia |
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