Diagnosis of Bladder Cancer With Microelectromechanical Systems-based Cystoscopic Optical Coherence Tomography

Objectives To examine the utility and potential limitations of microelectromechanical systems-based spectral-domain cystoscopic optical coherence tomography (COCT) so as to improve the diagnosis of early bladder cancer. Methods An optical coherence tomography catheter was integrated into the single...

Full description

Saved in:

Bibliographic Details
Published in:	Urology (Ridgewood, N.J.) Vol. 74; no. 6; pp. 1351 - 1357
Main Authors:	Ren, Hugang, Waltzer, Wayne C, Bhalla, Rahuldev, Liu, Jingxuan, Yuan, Zhijia, Lee, Christopher S.D, Darras, Frank, Schulsinger, David, Adler, Howard L, Kim, Jason, Mishail, Alek, Pan, Yingtian
Format:	Journal Article
Language:	English
Published:	United States Elsevier Inc 01-12-2009
Subjects:	Cystoscopy - methods Equipment Design Female Humans Male Tomography, Optical Coherence - instrumentation Urinary Bladder Neoplasms - pathology Urology
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Abstract	Objectives To examine the utility and potential limitations of microelectromechanical systems-based spectral-domain cystoscopic optical coherence tomography (COCT) so as to improve the diagnosis of early bladder cancer. Methods An optical coherence tomography catheter was integrated into the single instrument channel of a 22F cystoscope to permit white-light-guided COCT over a large field of view (4.6 mm wide and 2.1 mm deep per scan at 8 frames/s) and 10-μm resolution. Intraoperative COCT diagnosis was performed in 56 patients, with a total of 110 lesions examined and compared with biopsied histology. Results The overall sensitivity of COCT (94%) was significantly higher than cystoscopy (75%, P = .02) and voided cytology (59%, P = .005); the major enhancement over cystoscopy was for low-grade pTa-1 cancer and carcinoma in situ ( P <.018). The overall specificity of COCT (81%) was comparable to voided cytology (88.9%, P = .49), but significantly higher than cystoscopy (62.5%, P = .02). Conclusions The microelectromechanical systems-based COCT, owing to its high resolution and detection sensitivity and large field of view, offers great potential for “optical biopsy” to enhance the diagnosis of nonpapillary bladder tumors and their recurrences and to guide bladder tumor resection.
AbstractList	Objectives To examine the utility and potential limitations of microelectromechanical systems-based spectral-domain cystoscopic optical coherence tomography (COCT) so as to improve the diagnosis of early bladder cancer. Methods An optical coherence tomography catheter was integrated into the single instrument channel of a 22F cystoscope to permit white-light-guided COCT over a large field of view (4.6 mm wide and 2.1 mm deep per scan at 8 frames/s) and 10-μm resolution. Intraoperative COCT diagnosis was performed in 56 patients, with a total of 110 lesions examined and compared with biopsied histology. Results The overall sensitivity of COCT (94%) was significantly higher than cystoscopy (75%, P = .02) and voided cytology (59%, P = .005); the major enhancement over cystoscopy was for low-grade pTa-1 cancer and carcinoma in situ ( P <.018). The overall specificity of COCT (81%) was comparable to voided cytology (88.9%, P = .49), but significantly higher than cystoscopy (62.5%, P = .02). Conclusions The microelectromechanical systems-based COCT, owing to its high resolution and detection sensitivity and large field of view, offers great potential for “optical biopsy” to enhance the diagnosis of nonpapillary bladder tumors and their recurrences and to guide bladder tumor resection. To examine the utility and potential limitations of microelectromechanical systems-based spectral-domain cystoscopic optical coherence tomography (COCT) so as to improve the diagnosis of early bladder cancer. An optical coherence tomography catheter was integrated into the single instrument channel of a 22F cystoscope to permit white-light-guided COCT over a large field of view (4.6 mm wide and 2.1 mm deep per scan at 8 frames/s) and 10-μm resolution. Intraoperative COCT diagnosis was performed in 56 patients, with a total of 110 lesions examined and compared with biopsied histology. The overall sensitivity of COCT (94%) was significantly higher than cystoscopy (75%, P = .02) and voided cytology (59%, P = .005); the major enhancement over cystoscopy was for low-grade pTa-1 cancer and carcinoma in situ ( P <.018). The overall specificity of COCT (81%) was comparable to voided cytology (88.9%, P = .49), but significantly higher than cystoscopy (62.5%, P = .02). The microelectromechanical systems-based COCT, owing to its high resolution and detection sensitivity and large field of view, offers great potential for “optical biopsy” to enhance the diagnosis of nonpapillary bladder tumors and their recurrences and to guide bladder tumor resection. OBJECTIVESTo examine the utility and potential limitations of microelectromechanical systems-based spectral-domain cystoscopic optical coherence tomography (COCT) so as to improve the diagnosis of early bladder cancer.METHODSAn optical coherence tomography catheter was integrated into the single instrument channel of a 22F cystoscope to permit white-light-guided COCT over a large field of view (4.6 mm wide and 2.1 mm deep per scan at 8 frames/s) and 10-microm resolution. Intraoperative COCT diagnosis was performed in 56 patients, with a total of 110 lesions examined and compared with biopsied histology.RESULTSThe overall sensitivity of COCT (94%) was significantly higher than cystoscopy (75%, P = .02) and voided cytology (59%, P = .005); the major enhancement over cystoscopy was for low-grade pTa-1 cancer and carcinoma in situ (P < .018). The overall specificity of COCT (81%) was comparable to voided cytology (88.9%, P = .49), but significantly higher than cystoscopy (62.5%, P = .02).CONCLUSIONSThe microelectromechanical systems-based COCT, owing to its high resolution and detection sensitivity and large field of view, offers great potential for "optical biopsy" to enhance the diagnosis of nonpapillary bladder tumors and their recurrences and to guide bladder tumor resection. To examine the utility and potential limitations of microelectromechanical systems-based spectral-domain cystoscopic optical coherence tomography (COCT) so as to improve the diagnosis of early bladder cancer. An optical coherence tomography catheter was integrated into the single instrument channel of a 22F cystoscope to permit white-light-guided COCT over a large field of view (4.6 mm wide and 2.1 mm deep per scan at 8 frames/s) and 10-microm resolution. Intraoperative COCT diagnosis was performed in 56 patients, with a total of 110 lesions examined and compared with biopsied histology. The overall sensitivity of COCT (94%) was significantly higher than cystoscopy (75%, P = .02) and voided cytology (59%, P = .005); the major enhancement over cystoscopy was for low-grade pTa-1 cancer and carcinoma in situ (P < .018). The overall specificity of COCT (81%) was comparable to voided cytology (88.9%, P = .49), but significantly higher than cystoscopy (62.5%, P = .02). The microelectromechanical systems-based COCT, owing to its high resolution and detection sensitivity and large field of view, offers great potential for "optical biopsy" to enhance the diagnosis of nonpapillary bladder tumors and their recurrences and to guide bladder tumor resection.
Author	Mishail, Alek Bhalla, Rahuldev Ren, Hugang Darras, Frank Schulsinger, David Waltzer, Wayne C Adler, Howard L Lee, Christopher S.D Yuan, Zhijia Kim, Jason Liu, Jingxuan Pan, Yingtian
Author_xml	– sequence: 1 fullname: Ren, Hugang – sequence: 2 fullname: Waltzer, Wayne C – sequence: 3 fullname: Bhalla, Rahuldev – sequence: 4 fullname: Liu, Jingxuan – sequence: 5 fullname: Yuan, Zhijia – sequence: 6 fullname: Lee, Christopher S.D – sequence: 7 fullname: Darras, Frank – sequence: 8 fullname: Schulsinger, David – sequence: 9 fullname: Adler, Howard L – sequence: 10 fullname: Kim, Jason – sequence: 11 fullname: Mishail, Alek – sequence: 12 fullname: Pan, Yingtian
BackLink	https://www.ncbi.nlm.nih.gov/pubmed/19660795$$D View this record in MEDLINE/PubMed
BookMark	eNqFkU1v1DAQhi1URLeFnwDKjVPCOPHH-gKC8CkV9dAijpbjTHa9JPHWTpDy73G6KyFx4fRqNO-8o3nmilyMfkRCXlIoKFDx5lDMwfd-txQlgCqAFaDgCdlQXspcKcUvyCY1IGel4pfkKsYDAAgh5DNySZUQIBXfkPGjM7vRRxcz32UfetO2GLLajDbJTzfts-_OBo892in4Ae3ejM6aPrtb4oRDzBsTsc3qVPlo_dHZ7PY4PTpqv8eAKSi794PfBXPcL8_J0870EV-c9Zr8-Pzpvv6a39x--Va_v8ktE2LKDe-kKUvJEKWspDFq27BWsIZSK1SzbSvgtALFoUMu2y0y0UgpSmCGm07Y6pq8PuUeg3-YMU56cNFi35sR_Ry1rBiVFVVVcvKTM10ZY8BOH4MbTFg0Bb2S1gd9Jq1X0hqYTljT3KvzhrkZsP07dUabDO9OBkx3_nYYdLRuxdG6kGDq1rv_rnj7T4Lt3SP9X7hgPPg5jAmipjqWGvTd-u7120kg0RDVH-tqqp4
CitedBy_id	crossref_primary_10_1002_ijch_201200009 crossref_primary_10_1007_s00464_018_6578_1 crossref_primary_10_31491_CSRC_2017_12_005 crossref_primary_10_1016_j_pdpdt_2019_06_006 crossref_primary_10_5858_arpa_2018_0298_RA crossref_primary_10_1016_j_juro_2010_05_087 crossref_primary_10_1109_TBME_2014_2316535 crossref_primary_10_1016_j_juro_2011_10_131 crossref_primary_10_1109_JSTQE_2015_2510295 crossref_primary_10_1364_BOE_7_004995 crossref_primary_10_1002_lapl_201110035 crossref_primary_10_1007_s11934_018_0833_9 crossref_primary_10_1016_j_urology_2010_11_044 crossref_primary_10_1007_s42399_018_0016_5 crossref_primary_10_1227_NEU_0000000000000344 crossref_primary_10_1016_j_ucl_2015_01_001 crossref_primary_10_1117_1_3646530 crossref_primary_10_1007_s00432_018_2690_9 crossref_primary_10_1016_j_hoc_2014_10_013 crossref_primary_10_1080_21681805_2017_1283359 crossref_primary_10_5812_ijcm_106281 crossref_primary_10_4161_intv_28770 crossref_primary_10_1016_j_urolonc_2021_03_026 crossref_primary_10_1586_era_10_73 crossref_primary_10_3892_mco_2018_1566 crossref_primary_10_7243_2052_6962_1_6 crossref_primary_10_1364_BOE_7_000648
Cites_doi	10.1364/OL.27.001415 10.1364/OL.26.001966 10.1118/1.1418726 10.1097/01.ju.0000180413.98752.a1 10.1016/j.urology.2008.02.002 10.1117/1.2749744 10.1002/dc.2840130307 10.1117/1.2978059 10.1159/000019819 10.1016/S0022-5347(01)64900-0 10.1016/S0022-5347(01)66559-5 10.1016/S0022-5347(05)65351-7 10.1117/1.2800007 10.1016/S0022-5347(05)64270-X
ContentType	Journal Article
Copyright	Elsevier Inc. 2009 Elsevier Inc.
Copyright_xml	– notice: Elsevier Inc. – notice: 2009 Elsevier Inc.
DBID	CGR CUY CVF ECM EIF NPM AAYXX CITATION 7X8
DOI	10.1016/j.urology.2009.04.090
DatabaseName	Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed CrossRef MEDLINE - Academic
DatabaseTitle	MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) CrossRef MEDLINE - Academic
DatabaseTitleList	MEDLINE - Academic MEDLINE
Database_xml	– sequence: 1 dbid: ECM name: MEDLINE url: https://search.ebscohost.com/login.aspx?direct=true&db=cmedm&site=ehost-live sourceTypes: Index Database
DeliveryMethod	fulltext_linktorsrc
Discipline	Medicine
EISSN	1527-9995
EndPage	1357
ExternalDocumentID	10_1016_j_urology_2009_04_090 19660795 S0090429509007766 1_s2_0_S0090429509007766
Genre	Research Support, Non-U.S. Gov't Journal Article Research Support, N.I.H., Extramural
GrantInformation_xml	– fundername: NIDDK NIH HHS grantid: R01 DK059265 – fundername: NIDDK NIH HHS grantid: 2R01-DK059265 – fundername: NIDDK NIH HHS grantid: R01 DK059265-08 – fundername: NIDA NIH HHS grantid: R21 DA032228
GroupedDBID	--- --K --M -RU .1- .55 .FO .GJ .~1 0R~ 123 1B1 1P~ 1RT 1~. 1~5 29Q 3O- 4.4 457 4CK 4G. 53G 5RE 5VS 6PF 7-5 71M 8P~ 9JM AABNK AACTN AAEDT AAEDW AAEJM AAIKJ AAKOC AALRI AAOAW AAQFI AAQQT AAQXK AAWTL AAXKI AAXUO ABBQC ABFNM ABLJU ABMAC ABMZM ABOCM ABXDB ACDAQ ACIUM ACRLP ACRZS ADBBV ADEZE ADMUD AEBSH AEKER AENEX AEVXI AFCTW AFFNX AFJKZ AFKWA AFRHN AFTJW AFXIZ AGHFR AGUBO AGYEJ AHHHB AIEXJ AIKHN AITUG AJJEV AJOXV AJRQY AJUYK AKRWK ALMA_UNASSIGNED_HOLDINGS AMFUW AMRAJ ANZVX ASPBG AVWKF AXJTR AZFZN BKOJK BLXMC BNPGV CS3 DU5 EBS EFJIC EJD EO8 EO9 EP2 EP3 EX3 F5P FDB FEDTE FGOYB FIRID FNPLU FYGXN G-2 G-Q GBLVA HEA HMK HMO HVGLF HZ~ IHE J1W KOM L7B LZ2 M29 M41 MO0 N9A O-L O9- OAUVE OK. OW. OZT P-8 P-9 P2P PC. Q38 R2- RIG ROL RPZ SAE SCC SDF SDG SDP SEL SES SPCBC SSH SSZ T5K UV1 WH7 WOW WUQ X7M XPP Z5R ZGI ~G- AAIAV ABLVK ABYKQ AHPSJ AJBFU EFLBG LCYCR ZA5 CGR CUY CVF ECM EIF NPM AAYXX CITATION 7X8
ID	FETCH-LOGICAL-c466t-a5f7a2274ee7737aa98b4d64b11c69b8d305130950fe57d8e46b776204a5af6c3
ISSN	0090-4295
IngestDate	Fri Oct 25 01:36:55 EDT 2024 Thu Sep 26 15:53:06 EDT 2024 Sat Nov 02 12:26:14 EDT 2024 Fri Feb 23 02:21:11 EST 2024 Tue Oct 15 22:55:27 EDT 2024
IsDoiOpenAccess	false
IsOpenAccess	true
IsPeerReviewed	true
IsScholarly	true
Issue	6
Language	English
LinkModel	OpenURL
MergedId	FETCHMERGED-LOGICAL-c466t-a5f7a2274ee7737aa98b4d64b11c69b8d305130950fe57d8e46b776204a5af6c3
Notes	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
OpenAccessLink	https://europepmc.org/articles/pmc2789875?pdf=render
PMID	19660795
PQID	734173193
PQPubID	23479
PageCount	7
ParticipantIDs	proquest_miscellaneous_734173193 crossref_primary_10_1016_j_urology_2009_04_090 pubmed_primary_19660795 elsevier_sciencedirect_doi_10_1016_j_urology_2009_04_090 elsevier_clinicalkeyesjournals_1_s2_0_S0090429509007766
PublicationCentury	2000
PublicationDate	2009-12-01
PublicationDateYYYYMMDD	2009-12-01
PublicationDate_xml	– month: 12 year: 2009 text: 2009-12-01 day: 01
PublicationDecade	2000
PublicationPlace	United States
PublicationPlace_xml	– name: United States
PublicationTitle	Urology (Ridgewood, N.J.)
PublicationTitleAlternate	Urology
PublicationYear	2009
Publisher	Elsevier Inc
Publisher_xml	– name: Elsevier Inc
References	Wojtkowski, Kowalczyk, Leitgeb (bib13) 2002; 27 Pan, Lavelle, Meyers (bib8) 2001; 28 Kriegmair, Baumgartner, Knuchel (bib6) 1996; 155 Zagaynova, Streltsova, Gladkova (bib9) 2002; 167 Leyh, Marberger, Conort (bib5) 1999; 35 Pan, Xie, Fedder (bib14) 2001; 26 Tearney, Brezinski, Southern (bib7) 1997; 157 Wang, Durand, Schoenberg (bib10) 2005; 174 Pan, Wu, Yuan (bib15) 2007; 12 Available at Messing, Catalona (bib2) 1998 Cajulis, Haines, Friashidvegi (bib3) 1995; 13 . Wang, Lee, Waltzer (bib12) 2007; 12 Yuan, Wang, Pan (bib16) 2008; 13 Lerner, Goh, Tresser (bib11) 2008; 72 Sarosdy, Schellhammer, Bokinsky (bib4) 2002; 168 19962540 - Urology. 2009 Dec;74(6):1357; author reply 1357-8 Pan (10.1016/j.urology.2009.04.090_bib8) 2001; 28 Zagaynova (10.1016/j.urology.2009.04.090_bib9) 2002; 167 Pan (10.1016/j.urology.2009.04.090_bib15) 2007; 12 Cajulis (10.1016/j.urology.2009.04.090_bib3) 1995; 13 Sarosdy (10.1016/j.urology.2009.04.090_bib4) 2002; 168 Wang (10.1016/j.urology.2009.04.090_bib10) 2005; 174 Tearney (10.1016/j.urology.2009.04.090_bib7) 1997; 157 Pan (10.1016/j.urology.2009.04.090_bib14) 2001; 26 10.1016/j.urology.2009.04.090_bib1 Leyh (10.1016/j.urology.2009.04.090_bib5) 1999; 35 Wojtkowski (10.1016/j.urology.2009.04.090_bib13) 2002; 27 Kriegmair (10.1016/j.urology.2009.04.090_bib6) 1996; 155 Lerner (10.1016/j.urology.2009.04.090_bib11) 2008; 72 Wang (10.1016/j.urology.2009.04.090_bib12) 2007; 12 Yuan (10.1016/j.urology.2009.04.090_bib16) 2008; 13 Messing (10.1016/j.urology.2009.04.090_bib2) 1998
References_xml	– volume: 174 start-page: 2376 year: 2005 end-page: 2381 ident: bib10 article-title: Fluorescence guided optical coherence tomography for the diagnosis of early bladder cancer in a rat model publication-title: J Urol. contributor: fullname: Schoenberg – volume: 27 start-page: 1415 year: 2002 end-page: 1417 ident: bib13 article-title: Full range complex spectral optical coherence tomography technique in eye imaging publication-title: Opt Lett. contributor: fullname: Leitgeb – year: 1998 ident: bib2 article-title: Urothelial tumors of the urinary tract publication-title: Campbell's Urology contributor: fullname: Catalona – volume: 35 start-page: 52 year: 1999 end-page: 56 ident: bib5 article-title: Comparison of the BTA stat(TM) test with voided urine cytology and bladder wash cytology in the diagnosis and monitoring of bladder cancer publication-title: Eur Urol. contributor: fullname: Conort – volume: 13 start-page: 214 year: 1995 end-page: 223 ident: bib3 article-title: Cytology, flow-cytometry, image-analysis, and interphase cytogenetics by fluorescence in-situ hybridization in the diagnosis of transitional-cell carcinoma in bladder washes-a comparative-study publication-title: Diagn Cytopathol. contributor: fullname: Friashidvegi – volume: 13 start-page: 1 year: 2008 end-page: 10 ident: bib16 article-title: High-resolution imaging diagnosis and staging of bladder cancer: a comparison between optical coherence tomography and high-frequency ultrasound publication-title: J Biomed Opt. contributor: fullname: Pan – volume: 155 start-page: 105 year: 1996 end-page: 110 ident: bib6 article-title: Detection of early bladder cancer by 5-aminolevulinic acid induced porphyrin fluorescence publication-title: J Urol. contributor: fullname: Knuchel – volume: 167 start-page: 1492 year: 2002 end-page: 1496 ident: bib9 article-title: Morozov: in vivo optical coherence tomography feasibility for bladder disease publication-title: J Urol. contributor: fullname: Gladkova – volume: 72 start-page: 133 year: 2008 end-page: 137 ident: bib11 article-title: Optical coherence tomography as an adjunct to white light cystoscopy for intravesical real-time imaging and staging of bladder cancer publication-title: Urology contributor: fullname: Tresser – volume: 12 start-page: 1 year: 2007 end-page: 9 ident: bib12 article-title: In vivo bladder imaging with mems-based endoscopic spectral domain optical coherence tomography publication-title: J Biomed Opt. contributor: fullname: Waltzer – volume: 12 start-page: 1 year: 2007 end-page: 3 ident: bib15 article-title: Subcellular imaging of epithelium with Time-lapse optical coherence tomography publication-title: J Biomed Opt Lett. contributor: fullname: Yuan – volume: 168 start-page: 1950 year: 2002 end-page: 1954 ident: bib4 article-title: Clinical evaluation of a multitarget fluorescent in situ hybridization assay for detection of bladder cancer publication-title: J Urol. contributor: fullname: Bokinsky – volume: 157 start-page: 1915 year: 1997 end-page: 1919 ident: bib7 article-title: Optical biopsy in human urologic tissue using optical coherence tomography publication-title: J Urol. contributor: fullname: Southern – volume: 26 start-page: 1966 year: 2001 end-page: 1968 ident: bib14 article-title: Endoscopic optical coherence tomography based on a MEMS mirror publication-title: Opt Lett. contributor: fullname: Fedder – volume: 28 start-page: 2432 year: 2001 end-page: 2440 ident: bib8 article-title: Detection of tumorigenesis in rat bladders with optical coherence tomography publication-title: Med Phys. contributor: fullname: Meyers – year: 1998 ident: 10.1016/j.urology.2009.04.090_bib2 article-title: Urothelial tumors of the urinary tract contributor: fullname: Messing – volume: 27 start-page: 1415 year: 2002 ident: 10.1016/j.urology.2009.04.090_bib13 article-title: Full range complex spectral optical coherence tomography technique in eye imaging publication-title: Opt Lett. doi: 10.1364/OL.27.001415 contributor: fullname: Wojtkowski – volume: 26 start-page: 1966 year: 2001 ident: 10.1016/j.urology.2009.04.090_bib14 article-title: Endoscopic optical coherence tomography based on a MEMS mirror publication-title: Opt Lett. doi: 10.1364/OL.26.001966 contributor: fullname: Pan – volume: 28 start-page: 2432 year: 2001 ident: 10.1016/j.urology.2009.04.090_bib8 article-title: Detection of tumorigenesis in rat bladders with optical coherence tomography publication-title: Med Phys. doi: 10.1118/1.1418726 contributor: fullname: Pan – volume: 174 start-page: 2376 year: 2005 ident: 10.1016/j.urology.2009.04.090_bib10 article-title: Fluorescence guided optical coherence tomography for the diagnosis of early bladder cancer in a rat model publication-title: J Urol. doi: 10.1097/01.ju.0000180413.98752.a1 contributor: fullname: Wang – volume: 72 start-page: 133 year: 2008 ident: 10.1016/j.urology.2009.04.090_bib11 article-title: Optical coherence tomography as an adjunct to white light cystoscopy for intravesical real-time imaging and staging of bladder cancer publication-title: Urology doi: 10.1016/j.urology.2008.02.002 contributor: fullname: Lerner – volume: 12 start-page: 1 year: 2007 ident: 10.1016/j.urology.2009.04.090_bib12 article-title: In vivo bladder imaging with mems-based endoscopic spectral domain optical coherence tomography publication-title: J Biomed Opt. doi: 10.1117/1.2749744 contributor: fullname: Wang – volume: 13 start-page: 214 year: 1995 ident: 10.1016/j.urology.2009.04.090_bib3 article-title: Cytology, flow-cytometry, image-analysis, and interphase cytogenetics by fluorescence in-situ hybridization in the diagnosis of transitional-cell carcinoma in bladder washes-a comparative-study publication-title: Diagn Cytopathol. doi: 10.1002/dc.2840130307 contributor: fullname: Cajulis – volume: 13 start-page: 1 year: 2008 ident: 10.1016/j.urology.2009.04.090_bib16 article-title: High-resolution imaging diagnosis and staging of bladder cancer: a comparison between optical coherence tomography and high-frequency ultrasound publication-title: J Biomed Opt. doi: 10.1117/1.2978059 contributor: fullname: Yuan – volume: 35 start-page: 52 year: 1999 ident: 10.1016/j.urology.2009.04.090_bib5 article-title: Comparison of the BTA stat(TM) test with voided urine cytology and bladder wash cytology in the diagnosis and monitoring of bladder cancer publication-title: Eur Urol. doi: 10.1159/000019819 contributor: fullname: Leyh – ident: 10.1016/j.urology.2009.04.090_bib1 – volume: 157 start-page: 1915 year: 1997 ident: 10.1016/j.urology.2009.04.090_bib7 article-title: Optical biopsy in human urologic tissue using optical coherence tomography publication-title: J Urol. doi: 10.1016/S0022-5347(01)64900-0 contributor: fullname: Tearney – volume: 155 start-page: 105 year: 1996 ident: 10.1016/j.urology.2009.04.090_bib6 article-title: Detection of early bladder cancer by 5-aminolevulinic acid induced porphyrin fluorescence publication-title: J Urol. doi: 10.1016/S0022-5347(01)66559-5 contributor: fullname: Kriegmair – volume: 167 start-page: 1492 year: 2002 ident: 10.1016/j.urology.2009.04.090_bib9 article-title: Morozov: in vivo optical coherence tomography feasibility for bladder disease publication-title: J Urol. doi: 10.1016/S0022-5347(05)65351-7 contributor: fullname: Zagaynova – volume: 12 start-page: 1 year: 2007 ident: 10.1016/j.urology.2009.04.090_bib15 article-title: Subcellular imaging of epithelium with Time-lapse optical coherence tomography publication-title: J Biomed Opt Lett. doi: 10.1117/1.2800007 contributor: fullname: Pan – volume: 168 start-page: 1950 year: 2002 ident: 10.1016/j.urology.2009.04.090_bib4 article-title: Clinical evaluation of a multitarget fluorescent in situ hybridization assay for detection of bladder cancer publication-title: J Urol. doi: 10.1016/S0022-5347(05)64270-X contributor: fullname: Sarosdy
SSID	ssj0006667
Score	2.2042868
Snippet	Objectives To examine the utility and potential limitations of microelectromechanical systems-based spectral-domain cystoscopic optical coherence tomography... To examine the utility and potential limitations of microelectromechanical systems-based spectral-domain cystoscopic optical coherence tomography (COCT) so as... OBJECTIVESTo examine the utility and potential limitations of microelectromechanical systems-based spectral-domain cystoscopic optical coherence tomography...
SourceID	proquest crossref pubmed elsevier
SourceType	Aggregation Database Index Database Publisher
StartPage	1351
SubjectTerms	Cystoscopy - methods Equipment Design Female Humans Male Tomography, Optical Coherence - instrumentation Urinary Bladder Neoplasms - pathology Urology
Title	Diagnosis of Bladder Cancer With Microelectromechanical Systems-based Cystoscopic Optical Coherence Tomography
URI	https://www.clinicalkey.es/playcontent/1-s2.0-S0090429509007766 https://dx.doi.org/10.1016/j.urology.2009.04.090 https://www.ncbi.nlm.nih.gov/pubmed/19660795 https://search.proquest.com/docview/734173193
Volume	74
hasFullText	1
inHoldings	1
isFullTextHit
isPrint
link	http://sdu.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV1Zj9MwELa6i4R4QdyUS37grXJJ0iSOH9luUcWxSLtdgXixnNjZQ7vJqmkQ8OuZqZ0DaMUh8ZI2btM6M59nxpM5CHme-LBoojhlWvmGhSLxWZr5mokgzUWqciMy9OnOj_jBx2R_Fs4Gg6aPazf2XzkNY8BrzJz9C263PwoD8B54DkfgOhz_iO_7NnbOlhnZu0DBshxNkbdLEAGrUwyUX5au-82lwcTfNZ9c6XKGak2PpnBWYsbKWTZ6f2X93ZjJYWvSLsrLfqVrZ9seL209J3RKYBZYE81zMH497jkcDq2gm9cnymlN689ffbPo-aC-guHbOm_3sNuLtXDVaX2hzefmk7dn9RqDoHy_1A7kjf9C9GJBnEwWHgOtGPVlsu3c47DXF7DYULCnrOGUb1QE1idxPq7trbvCpFjT1us0X_O0fzZ947MqGHvsCGeDk4EXLHT0U5Vuu22SVSA9-ctXd8i1AKQdCttP0WFrDsD-0BVutbfZpZG92Di9bQbStg3Q2hBa3CI33Q6GvrTQu00GprhDrr9zMRp3SdEikJY5dQikFoEUEUg3I5D-gEDaQyB1CKQtAmmHwHvk-NVsMZ0z19WDZWEcr5iKcq6CgIfGcD7hSokkDXUcpr6fxSJNNGggMKyArrmJuE5MGKdA3sALVaTyOJvcJ7tFWZiHhGa5n2svzkWcxKHKctj8-1r4PFM6y5JID8m4IaW8ssVbZBPVeC4d7bERq5BeKIH2Q8IbgssmMxl0qancAq_kNuYPSdJe6WxXa5NKQOTv_pQ2rJUg2_GBnSpMWVeSg4nJQUdOhuSBZXl3G1hVl4vo0T_P-DG50S3HJ2R3tazNU7JT6frZGsDfAbDy0W0
link.rule.ids	315,782,786,27933,27934
linkProvider	Elsevier
openUrl	ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Diagnosis+of+Bladder+Cancer+With+Microelectromechanical+Systems-based+Cystoscopic+Optical+Coherence+Tomography&rft.jtitle=Urology+%28Ridgewood%2C+N.J.%29&rft.au=Ren%2C+Hugang&rft.au=Waltzer%2C+Wayne+C&rft.au=Bhalla%2C+Rahuldev&rft.au=Liu%2C+Jingxuan&rft.date=2009-12-01&rft.issn=0090-4295&rft.volume=74&rft.issue=6&rft.spage=1351&rft.epage=1357&rft_id=info:doi/10.1016%2Fj.urology.2009.04.090&rft.externalDBID=ECK1-s2.0-S0090429509007766&rft.externalDocID=1_s2_0_S0090429509007766
thumbnail_m	http://sdu.summon.serialssolutions.com/2.0.0/image/custom?url=https%3A%2F%2Fcdn.clinicalkey.com%2Fck-thumbnails%2F00904295%2FS0090429509X00117%2Fcov150h.gif