An esophageal neuroendocrine tumor metastatic to the pineal region

• Published in: Brain tumor pathology Vol. 31; no. 3; pp. 192 - 197
• Main Authors: Matsuda, K., Sakurada, K., Kokubo, Y., Sato, S., Nakazato, Y., Kayama, T.
• Format: Journal Article
• Language: English
• Published: Tokyo Springer Japan 01-07-2014; Springer Nature B.V
• Subjects: Aged; Biomarkers, Tumor - analysis; Biopsy; Brain cancer; Calcification; Cancer Research; Case Report; Case reports; Consciousness; Cytokeratin; Diffusion Magnetic Resonance Imaging; Endocrine system; Esophageal cancer; Esophageal Neoplasms - diagnosis; Esophageal Neoplasms - pathology; Esophageal Neoplasms - therapy; Fatal Outcome; Female; Humans; Hydrocephalus; Lymphatic Metastasis; Lymphatic system; Medicine; Medicine & Public Health; Metastasis; Neural Cell Adhesion Molecules - analysis; Neuroendocrine tumors; Neuroendocrine Tumors - diagnosis; Neuroendocrine Tumors - secondary; Neuroendocrine Tumors - therapy; Neurology; Neurosurgery; Oncology; Pathology; Patients; Pinealoma - diagnosis; Pinealoma - pathology; Pinealoma - secondary; Pinealoma - therapy; Tomography, Emission-Computed, Single-Photon; Tomography, X-Ray Computed; Esophageal Lesion; Esophageal Cancer; Metastatic Brain Tumor; Pineoblastoma; Pineal Region
• ISSN: 1433-7398; 1861-387X
• DOI: 10.1007/s10014-014-0178-0

[...]pineal region metastases are very rare; according to recent statistics, they account for only 0.3 % of all intracranial metastases [3]. [...]the pineal region is a site of predilection for primary tumors of the pineal region and germ cell tumors. [...]when lesions are seen in the pineal region, these tumors have higher priority in the differential diagnosis. [...]this very rare case is reported. [...]beginning in early July 2012, about 1 year after treatment, the patient had a gradual decline in activity levels and developed impaired consciousness. Since imaging studies showed a tumor in the pineal region and cerebral ventricular enlargement, she was referred to our department. [...]of hospital admission, the patient’s level of consciousness was JCS 3 (GCS 14), and she was disoriented and had an ocular motility disorder. MRI showed a decrease in the ventricular enlargement. Since intraoperative findings showed tumor dissemination in the cerebral ventricle, whole-brain irradiation (37.5 Gy) and booster irradiation (7.5 Gy) to the pineal region were given.