Role of the metabotropic glutamate receptor subtype 1 in the Harmaline-induced tremor in rats

• Published in: Journal of Neural Transmission Vol. 116; no. 9; pp. 1059 - 1063
• Main Authors: Kolasiewicz, Wacław, Kuter, Katarzyna, Wardas, Jadwiga, Ossowska, Krystyna
• Format: Journal Article
• Language: English
• Published: Vienna Springer Vienna 01-09-2009; Springer Nature B.V
• Subjects: Animals; Basic Neurosciences; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Exploratory Behavior - drug effects; Genetics and Immunology - Short Communication; Harmaline; Locomotion - drug effects; Male; Medicine; Medicine & Public Health; Neurology; Neurosciences; Psychiatry; Quinolines - pharmacology; Rats; Rats, Wistar; Receptors, Metabotropic Glutamate - antagonists & inhibitors; Receptors, Metabotropic Glutamate - metabolism; Time Factors; Tremor - chemically induced; Tremor - metabolism; Tremor - physiopathology; Harmaline; Cerebellum; Tremor; Glutamate metabotropic receptor subtype 1; Rat
• ISSN: 0300-9564; 1435-1463
• DOI: 10.1007/s00702-009-0254-5

The present study shows that JNJ 16259685—a selective antagonist of glutamate metabotropic receptor subtype 1 (mGluR1) injected in doses of 0.16 and 0.32 mg/kg sc strongly enhances tremor of forelimbs, head and trunk, hypolocomotion, and ataxia induced by harmaline (7.5 mg/kg ip) in rats. JNJ 16259685 inhibited locomotor and exploratory activity per se
.
These results may suggest an inhibitory influence of mGluR1 on the harmaline-induced motor disturbances.