A Phase Separation Model for Transcriptional Control
Phase-separated multi-molecular assemblies provide a general regulatory mechanism to compartmentalize biochemical reactions within cells. We propose that a phase separation model explains established and recently described features of transcriptional control. These features include the formation of...
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| Published in: | Cell Vol. 169; no. 1; pp. 13 - 23 |
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| Main Authors: | , , , , |
| Format: | Journal Article |
| Language: | English |
| Published: |
United States
Elsevier Inc
23-03-2017
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| Subjects: | |
| Online Access: | Get full text |
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| Abstract | Phase-separated multi-molecular assemblies provide a general regulatory mechanism to compartmentalize biochemical reactions within cells. We propose that a phase separation model explains established and recently described features of transcriptional control. These features include the formation of super-enhancers, the sensitivity of super-enhancers to perturbation, the transcriptional bursting patterns of enhancers, and the ability of an enhancer to produce simultaneous activation at multiple genes. This model provides a conceptual framework to further explore principles of gene control in mammals.
A phase separation model for transcription explains key features of transcription and sets enhancers, and especially super-enhancers, into the broad family of membraneless organelles. |
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| AbstractList | Phase-separated multi-molecular assemblies provide a general regulatory mechanism to compartmentalize biochemical reactions within cells. We propose that a phase separation model explains established and recently described features of transcriptional control. These features include the formation of super-enhancers, the sensitivity of super-enhancers to perturbation, the transcriptional bursting patterns of enhancers, and the ability of an enhancer to produce simultaneous activation at multiple genes. This model provides a conceptual framework to further explore principles of gene control in mammals. Phase-separated multi-molecular assemblies provide a general regulatory mechanism to compartmentalize biochemical reactions within cells. We propose that a phase separation model explains established and recently described features of transcriptional control. These features include the formation of super-enhancers, the sensitivity of super-enhancers to perturbation, the transcriptional bursting patterns of enhancers, and the ability of an enhancer to produce simultaneous activation at multiple genes. This model provides a conceptual framework to further explore principles of gene control in mammals. A phase separation model for transcription explains key features of transcription and sets enhancers, and especially super-enhancers, into the broad family of membraneless organelles. |
| Author | Shrinivas, Krishna Chakraborty, Arup K. Sharp, Phillip A. Young, Richard A. Hnisz, Denes |
| Author_xml | – sequence: 1 givenname: Denes surname: Hnisz fullname: Hnisz, Denes organization: Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, MA 02142, USA – sequence: 2 givenname: Krishna surname: Shrinivas fullname: Shrinivas, Krishna organization: Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA – sequence: 3 givenname: Richard A. surname: Young fullname: Young, Richard A. email: young@wi.mit.edu organization: Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, MA 02142, USA – sequence: 4 givenname: Arup K. surname: Chakraborty fullname: Chakraborty, Arup K. email: arupc@mit.edu organization: Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA – sequence: 5 givenname: Phillip A. surname: Sharp fullname: Sharp, Phillip A. email: sharppa@mit.edu organization: Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/28340338$$D View this record in MEDLINE/PubMed |
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| Keywords | nuclear body transcriptional burst enhancer phase separation co-operativity transcription gene control bursting super-enhancer |
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| Snippet | Phase-separated multi-molecular assemblies provide a general regulatory mechanism to compartmentalize biochemical reactions within cells. We propose that a... |
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| SubjectTerms | Animals bursting co-operativity enhancer Enhancer Elements, Genetic Eukaryotic Cells - metabolism gene control Gene Expression Regulation Humans Models, Biological nuclear body phase separation super-enhancer transcription Transcription Factors - metabolism Transcription, Genetic Transcriptional Activation transcriptional burst |
| Title | A Phase Separation Model for Transcriptional Control |
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