Resistance of Ehrlich tumor cells to apoptosis can be due to accumulation of heat shock proteins

Previously we have found that stationary Ehrlich ascites carcinoma (EAC) cells in vivo accumulated heat shock proteins (HSPs) and became resistant to necrotic heath induced by prolonged energy deprivation of hyperthermia. Here we report that apoptotic death induced by nutrient starvation, transient...

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Bibliographic Details
Published in:	FEBS letters Vol. 375; no. 1; pp. 21 - 26
Main Authors:	Gabai, Vladimir L., Zamulaeva, Irina V., Mosin, Alexei F., Makarova, Yulia M., Mosina, Vera A., Budagova, Karina R., Malutina, Yana V., Kabakov, Alexander E.
Format:	Journal Article
Language:	English
Published:	England Elsevier B.V 13-11-1995
Subjects:	Adenosine Triphosphate - metabolism Animals Antineoplastic Agents, Phytogenic - pharmacology Apoptosis Apoptosis - drug effects Apoptosis - physiology Carcinoma, Ehrlich Tumor - metabolism Carcinoma, Ehrlich Tumor - pathology Carcinoma, Ehrlich Tumor - physiopathology CCCP, carbonyl cyanide m-chlorophenylhydrazone Cell Cycle - drug effects Cell Cycle - physiology Chromatin - drug effects Chromatin - ultrastructure DMEM, Dulbecco's modified Eagle's minimal essential medium DNA fragmentation DNA, Neoplasm - analysis DNA, Neoplasm - isolation & purification DNA, Neoplasm - metabolism EAC, Ehrlich ascites carcinoma Ehrlich ascites carcinoma Electrophoresis, Agar Gel Heat shock proteins Heat-Shock Proteins - biosynthesis Hot Temperature HSP, heat shock protein Mice Mice, Inbred C57BL Microtubules - drug effects PBS, phosphate-buffered saline Vinblastine - pharmacology EAC, Ehrlich ascites carcinoma CCCP, carbonyl cyanide m-chlorophenylhydrazone PBS, phosphate-buffered saline DNA fragmentation Ehrlich ascites carcinoma DMEM, Dulbecco's modified Eagle's minimal essential medium Heat shock proteins HSP, heat shock protein Apoptosis
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