Convalescent human plasma candidate reference materials protect against Crimean-Congo haemorrhagic fever virus (CCHFV) challenge in an A129 mouse model

•Convalescent human plasma can protect against CCHFV challenge in a mouse model.•The protection afforded by the convalescent plasma was titratable.•Defining the protective level of anti-CCHFV antibodies supports vaccine development. Crimean-Congo Haemorrhagic Fever Virus (CCHFV) is spread by infecte...

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Bibliographic Details
Published in:	Virus research Vol. 346; p. 199409
Main Authors:	Kempster, Sarah, Hassall, Mark, Graham, Victoria, Kennedy, Emma, Findlay-Wilson, Stephen, Salguero, Francisco J., Bagci, Binnur, Elaldi, Nazif, Oz, Murtaza, Tasseten, Tuba, Charlton, Frank W., Barr, John N., Fontana, Juan, Duru, Chinwe, Ezeajughi, Ernest, Matejtschuk, Paul, Arnold, Ulrike, Adedeji, Yemisi, Mirazimi, Ali, Hewson, Roger, Dowall, Stuart, Almond, Neil
Format:	Journal Article
Language:	English
Published:	Netherlands Elsevier B.V 01-08-2024 Elsevier
Subjects:	Animals Antibodies, Neutralizing - blood Antibodies, Neutralizing - immunology Antibodies, Viral - blood Antibodies, Viral - immunology CCHF CCHFV Convalescent Disease Models, Animal Female Hemorrhagic Fever Virus, Crimean-Congo - immunology Hemorrhagic Fever, Crimean - immunology Hemorrhagic Fever, Crimean - prevention & control Humans Immunity Infection Male Medicin och hälsovetenskap Mice Mouse model Neutralization Tests Plasma - immunology Vaccine Infection CCHF Convalescent CCHFV Mouse model Vaccine Immunity
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