Synthetic Strategies, Reactivity and Applications of 1,5-Naphthyridines

• Published in: Molecules (Basel, Switzerland) Vol. 25; no. 14; p. 3252
• Main Authors: Fuertes, Maria, Masdeu, Carme, Martin-Encinas, Endika, Selas, Asier, Rubiales, Gloria, Palacios, Francisco, Alonso, Concepcion
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI 16-07-2020; MDPI AG
• Subjects: 1,5-naphthyridines; biological activity; Chemistry, Pharmaceutical; Coordination Complexes - chemical synthesis; Coordination Complexes - chemistry; heterocycle synthesis; Indicators and Reagents - chemical synthesis; Indicators and Reagents - chemistry; metal complexes; Naphthyridines - chemical synthesis; Naphthyridines - chemistry; Review; metal complexes; heterocycle synthesis; biological activity; 1,5-naphthyridines
• ISSN: 1420-3049; 1420-3049
• DOI: 10.3390/molecules25143252

This review covers the synthesis and reactivity of 1,5-naphthyridine derivatives published in the last 18 years. These heterocycles present a significant importance in the field of medicinal chemistry because many of them exhibit a great variety of biological activities. First, the published strategies related to the synthesis of 1,5-naphthyridines are presented followed by the reactivity of these compounds with electrophilic or nucleophilic reagents, in oxidations, reductions, cross-coupling reactions, modification of side chains or formation of metal complexes. Finally, some properties and applications of these heterocycles studied during this period are examined.