Transporter-Mediated Solutes Uptake as Drug Target in Plasmodium falciparum

Transporter-Mediated Solutes Uptake as Drug Target in Plasmodium falciparum

Malaria remains a public health problem with still more than half a million deaths annually. Despite ongoing efforts of many countries, malaria elimination has been difficult due to emerging resistances against most traditional drugs, including artemisinin compounds - the most potent antimalarials c...

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Bibliographic Details
Published in:Frontiers in pharmacology Vol. 13; p. 845841
Main Authors: Monteiro Júnior, Júlio César, Krüger, Arne, Palmisano, Giuseppe, Wrenger, Carsten
Format: Journal Article
Language:English
Published: Switzerland Frontiers Media S.A 07-02-2022
Subjects:
malaria
new drugs
P. falciparum
Pharmacology
resistance
solute uptake
transporters
solute uptake
transporters
malaria
P. falciparum
new drugs
resistance
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Summary:Malaria remains a public health problem with still more than half a million deaths annually. Despite ongoing efforts of many countries, malaria elimination has been difficult due to emerging resistances against most traditional drugs, including artemisinin compounds - the most potent antimalarials currently available. Therefore, the discovery and development of new drugs with novel mechanisms of action to circumvent resistances is urgently needed. In this sense, one of the most promising areas is the exploration of transport proteins. Transporters mediate solute uptake for intracellular parasite proliferation and survival. Targeting transporters can exploit these processes to eliminate the parasite. Here, we focus on transporters of the -infected red blood cell studied as potential biological targets and discuss published drugs directed at them.
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Edited by: Paula Gomes, University of Porto, Portugal
Roberto Rudge Moraes Barros, Federal University of São Paulo, Brazil
ORCID: Júlio César Monteiro Júnior, orcid.org/0000-0002-1732-7507; Arne Krüger, orcid.org/0000-0002-5531-9508; Giuseppe Palmisano, orcid.org/0000-0003-1336-6151; Carsten Wrenger, orcid.org/0000-0001-5987-1749
This article was submitted to Experimental Pharmacology and Drug Discovery, a section of the journal Frontiers in Pharmacology
Reviewed by: Marcos L Gazarini, Federal University of São Paulo, Brazil
ISSN:1663-9812
1663-9812
DOI:10.3389/fphar.2022.845841