Dose-dependent severe cutaneous reactions to imatinib
The protein kinase inhibitor imatinib has been approved as an efficient anticancer drug with common but mild cutaneous toxicities. We here report on two out of four melanoma patients treated with high-dose imatinib presenting with severe and strongly dose-dependent skin eruptions, suggesting a cutan...
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| Published in: | British journal of cancer Vol. 88; no. 8; pp. 1157 - 1159 |
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| Main Authors: | , , , , |
| Format: | Journal Article |
| Language: | English |
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Basingstoke
Nature Publishing Group
22-04-2003
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| Abstract | The protein kinase inhibitor imatinib has been approved as an efficient anticancer drug with common but mild cutaneous toxicities. We here report on two out of four melanoma patients treated with high-dose imatinib presenting with severe and strongly dose-dependent skin eruptions, suggesting a cutaneous reactivity pattern different from allergic hypersensitivity. |
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| AbstractList | The protein kinase inhibitor imatinib has been approved as an efficient anticancer drug with common but mild cutaneous toxicities. We here report on two out of four melanoma patients treated with high-dose imatinib presenting with severe and strongly dose-dependent skin eruptions, suggesting a cutaneous reactivity pattern different from allergic hypersensitivity. |
| Author | HILDENBRAND, R SCHADENDORF, D UGUREL, S HOCHHAUS, A DIPPER, E |
| Author_xml | – sequence: 1 givenname: S surname: UGUREL fullname: UGUREL, S organization: Skin Cancer Unit, German Cancer Research Center, 69120 Heidelberg, Germany – sequence: 2 givenname: R surname: HILDENBRAND fullname: HILDENBRAND, R organization: Institute of Pathology, University Hospital of Mannheim, 68167 Mannheim, Germany – sequence: 3 givenname: E surname: DIPPER fullname: DIPPER, E organization: Department of Dermatology, University Hospital of Mannheim, 68167 Mannheim, Germany – sequence: 4 givenname: A surname: HOCHHAUS fullname: HOCHHAUS, A organization: Department of Internal Medicine, University Hospital of Mannheim, 68167 Mannheim, Germany – sequence: 5 givenname: D surname: SCHADENDORF fullname: SCHADENDORF, D organization: Skin Cancer Unit, German Cancer Research Center, 69120 Heidelberg, Germany |
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| Cites_doi | 10.1056/NEJM200104053441401 10.1097/00008390-199602000-00004 10.1182/blood.V99.10.3530 10.1056/NEJMoa020461 10.1056/NEJMoa011573 10.1182/blood.V99.5.1741 10.1182/blood.V99.6.1928 10.1016/S0140-6736(01)06535-7 10.1056/NEJM200108233450814 |
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| Keywords | Antineoplastic agent Human Skin disease Imatinib Enzyme Toxicity c-kit Transferases Exanthema Melanoma Enzyme inhibitor Malignant tumor mast cells Dose activity relation Chemotherapy Treatment adverse drug reaction Complication Advanced stage High dose Protein-tyrosine kinase |
| Language | English |
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| References | Kantarjian, H, Sawyers, C, Hochhaus, A, Guilhot, F, Schiffer, C, Gambacorti-Passerini, C, Niederwieser, D, Resta, D, Capdeville, R, Zoellner, U, Talpaz, M, Druker, B, Goldman, J, O'Brien, SG, Russell, N, Fischer, T, Ottmann, O, Cony-Makhoul, P, Facon, T, Stone, R, Miller, C, Tallman, M, Brown, R, Schuster, M, Loughran, T, Gratwohl, A, Mandelli, F, Saglio, G, Lazzarino, M, Russo, D, Baccarani, M, Morra, E 2002; 346 Ma, Y, Zeng, S, Metcalfe, DD, Akin, C, Dimitrijevic, S, Butterfield, JH, McMahon, G, Longley, BJ 2002; 99 Sawyers, CL, Hochhaus, A, Feldman, E, Goldman, JM, Miller, CB, Ottmann, OG, Schiffer, CA, Talpaz, M, Guilhot, F, Deininger, MW, Fischer, T, O'Brien, SG, Stone, RM, Gambacorti-Passerini, CB, Russell, NH, Reiffers, JJ, Shea, TC, Chapuis, B, Coutre, S, Tura, S, Morra, E, Larson, RA, Saven, A, Peschel, C, Gratwohl, A, Mandelli, F, Ben-Am, M, Gathmann, I, Capdeville, R, Paquette, RL, Druker, BJ 2002; 99 van Oosterom, AT, Judson, I, Verweij, J, Stroobants, S, Donato di Paola, E, Dimitrijevic, S, Martens, M, Webb, A, Sciot, R, Van Glabbeke, M, Silberman, S, Nielsen, OS 2001; 358 Brouard, M, Saurat, JH 2001; 345 Talpaz, M, Silver, RT, Druker, BJ, Goldman, JM, Gambacorti-Passerini, C, Guilhot, F, Schiffer, CA, Fischer, T, Deininger, MW, Lennard, AL, Hochhaus, A, Ottmann, OG, Gratwohl, A, Baccarani, M, Stone, R, Tura, S, Mahon, FX, Fernandes-Reese, S, Gathmann, I, Capdeville, R, Kantarjian, HM, Sawyers, CL 2002; 99 Druker, BJ, Talpaz, M, Resta, DJ, Peng, B, Buchdunger, E, Ford, JM, Lydon, NB, Kantarjian, H, Capdeville, R, Ohno-Jones, S, Sawyers, CL 2001; 344 Demetri, GD, von Mehren, M, Blanke, CD, van den Abbeele, AD, Eisenberg, B, Roberts, PJ, Heinrich, MC, Tuveson, DA, Singer, S, Janicek, M, Fletcher, JA, Silverman, SG, Silberman, SL, Capdeville, R, Kiese, B, Peng, B, Dimitrijevic, S, Druker, BJ, Corless, C, Fletcher, CD, Joensuu, H 2002; 347 Ohashi, A, Funasaka, Y, Ueda, M, Ichihashi, M 1996; 6 11287972 - N Engl J Med. 2001 Apr 5;344(14):1031-7 12181401 - N Engl J Med. 2002 Aug 15;347(7):472-80 11529225 - N Engl J Med. 2001 Aug 23;345(8):618-9 11877262 - Blood. 2002 Mar 15;99(6):1928-37 11986204 - Blood. 2002 May 15;99(10):3530-9 11705489 - Lancet. 2001 Oct 27;358(9291):1421-3 8640066 - Melanoma Res. 1996 Feb;6(1):25-30 11870241 - N Engl J Med. 2002 Feb 28;346(9):645-52 11861291 - Blood. 2002 Mar 1;99(5):1741-4 A Ohashi (BF6600893_CR6) 1996; 6 CL Sawyers (BF6600893_CR7) 2002; 99 M Talpaz (BF6600893_CR8) 2002; 99 M Brouard (BF6600893_CR1) 2001; 345 BJ Druker (BF6600893_CR3) 2001; 344 AT van Oosterom (BF6600893_CR9) 2001; 358 H Kantarjian (BF6600893_CR4) 2002; 346 Y Ma (BF6600893_CR5) 2002; 99 GD Demetri (BF6600893_CR2) 2002; 347 |
| References_xml | – volume: 345 start-page: 618 year: 2001 end-page: 619 article-title: Cutaneous reactions to STI571 publication-title: N Engl J Med contributor: fullname: Saurat, JH – volume: 99 start-page: 1928 year: 2002 end-page: 1937 article-title: Imatinib induces durable hematologic and cytogenetic responses in patients with accelerated phase chronic myeloid leukemia: results of a phase 2 study publication-title: Blood contributor: fullname: Sawyers, CL – volume: 346 start-page: 645 year: 2002 end-page: 652 article-title: Hematologic and cytogenetic responses to imatinib mesylate in chronic myelogenous leukemia publication-title: N Engl J Med contributor: fullname: Morra, E – volume: 347 start-page: 472 year: 2002 end-page: 480 article-title: Efficacy and safety of imatinib mesylate in advanced gastrointestinal stromal tumors publication-title: N Engl J Med contributor: fullname: Joensuu, H – volume: 99 start-page: 1741 year: 2002 end-page: 1744 article-title: The c-KIT mutation causing human mastocytosis is resistant to STI571 and other KIT kinase inhibitors; kinases with enzymatic site mutations show different inhibitor sensitivity profiles than wild-type kinases and those with regulatory-type mutations publication-title: Blood contributor: fullname: Longley, BJ – volume: 344 start-page: 1031 year: 2001 end-page: 1037 article-title: Efficacy and safety of a specific inhibitor of the BCR-ABL tyrosine kinase in chronic myeloid leukemia publication-title: N Engl J Med contributor: fullname: Sawyers, CL – volume: 6 start-page: 25 year: 1996 end-page: 30 article-title: c-KIT receptor expression in cutaneous malignant melanoma and benign melanotic naevi publication-title: Melanoma Res contributor: fullname: Ichihashi, M – volume: 99 start-page: 3530 year: 2002 end-page: 3539 article-title: Imatinib induces hematologic and cytogenetic responses in patients with chronic myelogenous leukemia in myeloid blast crisis: results of a phase II study publication-title: Blood contributor: fullname: Druker, BJ – volume: 358 start-page: 1421 year: 2001 end-page: 1423 article-title: Safety and efficacy of imatinib (STI571) in metastatic gastrointestinal stromal tumours: a phase I study publication-title: Lancet contributor: fullname: Nielsen, OS – volume: 344 start-page: 1031 year: 2001 ident: BF6600893_CR3 publication-title: N Engl J Med doi: 10.1056/NEJM200104053441401 contributor: fullname: BJ Druker – volume: 6 start-page: 25 year: 1996 ident: BF6600893_CR6 publication-title: Melanoma Res doi: 10.1097/00008390-199602000-00004 contributor: fullname: A Ohashi – volume: 99 start-page: 3530 year: 2002 ident: BF6600893_CR7 publication-title: Blood doi: 10.1182/blood.V99.10.3530 contributor: fullname: CL Sawyers – volume: 347 start-page: 472 year: 2002 ident: BF6600893_CR2 publication-title: N Engl J Med doi: 10.1056/NEJMoa020461 contributor: fullname: GD Demetri – volume: 346 start-page: 645 year: 2002 ident: BF6600893_CR4 publication-title: N Engl J Med doi: 10.1056/NEJMoa011573 contributor: fullname: H Kantarjian – volume: 99 start-page: 1741 year: 2002 ident: BF6600893_CR5 publication-title: Blood doi: 10.1182/blood.V99.5.1741 contributor: fullname: Y Ma – volume: 99 start-page: 1928 year: 2002 ident: BF6600893_CR8 publication-title: Blood doi: 10.1182/blood.V99.6.1928 contributor: fullname: M Talpaz – volume: 358 start-page: 1421 year: 2001 ident: BF6600893_CR9 publication-title: Lancet doi: 10.1016/S0140-6736(01)06535-7 contributor: fullname: AT van Oosterom – volume: 345 start-page: 618 year: 2001 ident: BF6600893_CR1 publication-title: N Engl J Med doi: 10.1056/NEJM200108233450814 contributor: fullname: M Brouard |
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| SubjectTerms | Adult Aged Antineoplastic Agents - toxicity Benzamides Biological and medical sciences Clinical Drug Hypersensitivity - pathology Drug toxicity and drugs side effects treatment Female Humans Imatinib Mesylate Male Medical sciences Middle Aged Pharmacology. Drug treatments Piperazines - toxicity Pyrimidines - toxicity Skin Diseases - chemically induced Skin Diseases - pathology Toxicity: skin, dermoskeleton |
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| Title | Dose-dependent severe cutaneous reactions to imatinib |
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