A Myristoylated Calcium-Binding Protein That Preferentially Interacts with the Alzheimer's Disease Presenilin 2 Protein

It is well established that mutations in the presenilin 1 and 2 genes cause the majority of early onset Alzheimer's disease (AD). However, our understanding of the cellular functions of the proteins they encode remains rudimentary. Knowledge of proteins with which the presenilins interact shoul...

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Bibliographic Details
Published in:	The Journal of cell biology Vol. 145; no. 6; pp. 1277 - 1292
Main Authors:	Stabler, Stacy M., Ostrowski, Lisa L., Janicki, Susan M., Monteiro, Mervyn J.
Format:	Journal Article
Language:	English
Published:	United States Rockefeller University Press 14-06-1999 The Rockefeller University Press
Subjects:	Alzheimer Disease - genetics Alzheimer Disease - metabolism Alzheimer's disease Alzheimers disease Amino Acid Sequence Antibodies Apoptosis Calcium Calcium - metabolism Calcium-Binding Proteins - analysis Calcium-Binding Proteins - chemistry Calcium-Binding Proteins - genetics Calcium-Binding Proteins - metabolism calmyrin Cell membranes Cell nucleus Cell Nucleus - metabolism Cells Cellular biology Chromatography, Affinity Cytoplasm - metabolism Endoplasmic Reticulum - metabolism Fluorescent Antibody Technique Gene Expression HeLa Cells Humans Lipoproteins - analysis Lipoproteins - chemistry Lipoproteins - genetics Lipoproteins - metabolism Membrane Proteins - analysis Membrane Proteins - chemistry Membrane Proteins - genetics Membrane Proteins - metabolism Molecular Sequence Data Myristic Acids - metabolism Neurons Peptide Fragments - chemistry Peptide Fragments - genetics Peptide Fragments - metabolism Precipitin Tests Presenilin-2 Presenilins Protein Binding Proteins RNA, Messenger - analysis RNA, Messenger - genetics RNA, Messenger - metabolism Transfection Yeasts Yeasts - genetics Yeasts - metabolism
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