Cell type-specific abundance of 4EBP1 primes prostate cancer sensitivity or resistance to PI3K pathway inhibitors

Pharmacological inhibitors against the PI3K-AKT-mTOR (phosphatidylinositol 3-kinase-AKT-mammalian target of rapamycin) pathway, a frequently deregulated signaling pathway in cancer, are clinically promising, but the development of drug resistance is a major limitation. We found that 4EBP1, the centr...

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Bibliographic Details

Published in:	Science signaling Vol. 8; no. 403; p. ra116
Main Authors:	Hsieh, Andrew C, Nguyen, Hao G, Wen, Lexiaochuan, Edlind, Merritt P, Carroll, Peter R, Kim, Won, Ruggero, Davide
Format:	Journal Article
Language:	English
Published:	United States 17-11-2015
Subjects:	Adaptor Proteins, Signal Transducing - genetics Adaptor Proteins, Signal Transducing - physiology Cell Line, Tumor Drug Resistance, Neoplasm Enzyme Inhibitors - pharmacology Epithelial Cells - metabolism Humans Male Phosphatidylinositol 3-Kinases - antagonists & inhibitors Phosphoproteins - genetics Phosphoproteins - physiology Prostatic Neoplasms - pathology RNA, Messenger - genetics TOR Serine-Threonine Kinases - metabolism
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